Research topics
Protein structure prediction and design:
Understanding the principles of protein folding especially the energetics will enable us to predict protein structures from their sequences. We have developed an efficient conformational sampling method for fragment-assembly based de novo protein structure prediction called EdaFold that uses an Estimation of Distribution Algorithm. This method has achieved top performance in the template-free modeling category of CASP10. We have developed one of the fastest exact cluster method called Durandal that can be used to identify a good protein model among many decoys.
Protein design allows us to explore large regions of the protein universe not yet observed in nature. We are interested in applying the protein design principles to create proteins with novel architectures, new biological functions or effective therapeutics.
Please refer to the following items for details:
Protein design allows us to explore large regions of the protein universe not yet observed in nature. We are interested in applying the protein design principles to create proteins with novel architectures, new biological functions or effective therapeutics.
Please refer to the following items for details: