Publications

  1. Malay, A. D., Watanabe, M., Heddle, J. G. & Tame, J. R. H. (2011). Crystal structure of unliganded TRAP: implications for dynamic allostery. Biochem. J. 434, 429-434.
  2. Miranda, F. F., Iwasaki, K., Akashi, S., Sumitomo, K., Kobayashi, M., Yamashita, I., Tame, J. R. H. and Heddle, J. G. (2009). A Self-Assembled Protein Nanotube with High Aspect Ratio. Small 5, 2077-2084.
  3. Satoko Akashi Masahiro Watanabe, Jonathan G. Heddle, Satoru Unzai, Sam-Yong Park and Jeremy R. H. Tame (2009). RNA and Protein Complexes of trp RNA-Binding Attenuation Protein Characterized by Mass Spectrometry. Anal. Chem. 81, 2218-2226
  4. Masahiro Watanabe, Jonathan G. Heddle, Satoru Unzai, Satoko Akashi, Sam-Yong Park and Jeremy R. H. Tame. (2009). Nature of the TRAP:Anti-TRAP complex revealed by symmetry remodeling. Proc. Nat. Acad. Sci. USA 106, 2176-81
  5. Watanabe, M., Mishima, Y., Yamashita, I., Park, S.-Y., Tame, J. R. H. & Heddle, J. G. (2008). Intersubunit linker length as a modifier of protein stability: Crystal structures and thermostability of mutant TRAP. Protein Sci. 17, 518-526
  6. Jonathan G. Heddle. (2008). Protein Cages, Rings and Tubes: Useful Components of Future Nanodevices? Nanotechnology, Science and Applications 1, 67-78
  7. Heddle, J. G., Fujiwara, I., Yamadaki, H., Yoshii, S., Nishio, K., Addy, C., Yamashita, I. & Tame, J. R. H. (2007). Using the Ring-Shaped Protein TRAP to Capture and Confine Gold Nanodots on a Surface. Small 3, 1950-1956.
  8. Yoshizawa, K., Mishima, Y., Park, S. Y., Heddle, J. G., Tame, J. R., Iwahori, K., Kobayashi, M. & Yamashita, I. (2007). Effect of N-terminal residues on the structural stability of recombinant horse L-chain apoferritin in an acidic environment. J. Biochem. (Tokyo) 142, 707-713.
  9. Heddle, J. G., Okajima, T., Scott, D. J., Akashi, S., Park, S. Y. & Tame, J. R. (2007). Dynamic allostery in the ring protein TRAP. J. Mol. Biol. 371, 154-67.
  10. Addy, C.,Ohara, M., Kawai, F., Kidera, A., Ikeguchi, M., Fuchigami, S., Osawa, M., Shimada, I., Park, S. Y., Tame, J. R. H. and Heddle, J. G., (2007). #Nickel binding to NikA: An additional binding site reconciles spectroscopy, calorimetry and crystallography. Acta Cryst. D63, 221-229.
  11. Heddle, J.G., Yokoyama, T., Yamashita, I., Park, S.Y., Tame, J.R.H. (2006). Rounding Up: Engineering 12-membered rings from the cyclic 11-mer TRAP. Structure 14, 925-33.
  12. Otto, B. R., Sijbrandi, R., Luirink, J., Oudega, B., Heddle, J. G., Mizutani, K., Park, S. Y. & Tame, J. R. (2005). Crystal structure of hemoglobin protease, a heme binding autotransporter protein from pathogenic Escherichia coli. J. Biol. Chem. 280, 17339-45
  13. Rajesh, S., Heddle, J. G., Kurashima-Ito, K., Nietlispach, D., Shirakawa, M., Tame, J. R. & Ito, Y. (2005). Backbone 1H, 13C, and 15N assignments of a 56 kDa E. coli nickel binding protein NikA. J Biomol NMR 32, 177
  14. Strumberg, D., Nitiss, J. L., Dong, J., Walker, J., Nicklaus, M. C., Kohn, K. W., Heddle, J. G., Maxwell, A., Seeber, S. & Pommier, Y. (2002). Importance of the fourth alpha-helix within the CAP homology domain of type II topoisomerase for DNA cleavage site recognition and quinolone action. Antimicrob Agents Chemother 46, 2735-46.
  15. Heddle, J. G., Mitelheiser, S., Maxwell, A. & Thomson, N. H. (2004). Nucleotide binding to DNA gyrase causes loss of DNA wrap. J. Mol. Biol. 337, 597-610
  16. Heddle, J., Scott, D. J., Unzai, S., Park, S. Y. & Tame, J. R. (2003). Crystal structures of the liganded and unliganded nickel-binding protein NikA from Escherichia coli. J.Biol.Chem.278, 50322-9.
  17. Heddle, J. & Maxwell, A. (2002). Quinolone-binding pocket of DNA gyrase: role of GyrB. Antimicrob.Agents Chemother.46, 1805-15
  18. Zamble, D. B., Miller, D. A., Heddle, J. G., Maxwell, A., Walsh, C. T. & Hollfelder, F. (2001). In vitro characterization of DNA gyrase inhibition by microcin B17 analogs with altered bisheterocyclic sites. Proc.Natl.Acad.Sci.U S A 98, 7712-7
  19. Heddle, J. G., Lu, T., Zhao, X., Drlica, K. & Maxwell, A. (2001).GyrB-225, a mutation of DNA gyrase that compensates for topoisomerase I deficiency: investigation of its low activity and quinolone hypersensitivity. J.Mol.Biol.309, 1219-31. 1249-64.
  20. Heddle, J. G., Blance, S. J., Zamble, D. B., Hollfelder, F., Miller, D. A., Wentzell, L. M., Walsh, C. T. & Maxwell, A. (2001). The antibiotic microcin B17 is a DNA gyrase poison: characterisation of the mode of inhibition. J.Mol.Biol.307, 1223-34.
  21. Heddle, J. G., Barnard, F. M., Wentzell, L. M. & Maxwell, A. (2000). The interaction of drugs with DNA gyrase: a model for the molecular basis of quinolone action. Nucleosides Nucleotides Nucleic Acids 19,11.