Lab Members

Kondo Eitaro

I am working on two projects relating to both nanoscience and antibiotics.

The programmable arrangement of protein on a DNA origami scaffold.
This research will help us to understand how we can control the patterning of biomolecule in bionanotechnology. DNA is powerful tool as a scaffold because of its well-understood structural properties. We are making DNA sheets with modified regions for capturing protein. Currently we are measuring and optimizing the specificity of binding between DNA and protein. We will apply the information learned from this to carry out more complete programmable arrangement of protein on the DNA scaffold.

Biochemical investigation of novel protein inhibitors of topoisomerases.
Topoisomerases are important targets for both antibacterial and anti-cancer therapeutics, but resistance to existing drugs is constantly evolving, necessitating the need to develop new drugs with different target sites. I am investigating one such protein for activity against a range of topoisomerases.