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Postdoctoral Researcher

Po-Hung Wang

EDUCATION
2013
Ph.D. (Physics) University College London, UK.
2009
M.Phil. (Chemistry) University of Cambridge, UK.
2006
B.S. (Chemistry) National Taiwan University, Taiwan.
2005
Visiting student at the University of Tokyo, Japan.
RESEARCH AND TEACHING EXPERIENCES
2013-present
Postdoctoral Researcher, RIKEN Theoretical Molecular Science Laboratory, Japan
2006-2008
Research Assistant, Department of Life Sciences, National Yang-Ming University, Taiwan
AWARDS AND GRANTS
2010
Skinner Poster Prize for Faraday Discussion 148: Bioinorganic Chemistry, Royal Society of Chemistry, UK
2009-2012
UCL Studentship, UK
2009-2011
Studying Abroad Scholarship, Ministry of Education, Taiwan
PROFESSIONAL AFFILIATIONS
American Biophysical Society, American Chemical Society, The Biophysical Society of Japan, Royal Society of Chemistry
RESEARCH PROJECTS
  1. Atomistic level MEK-ERK interactions
  2. Water structure and dynamics in the crowded environment
  3. Protein motions in the crowded environment
PUBLICATIONS
(Google Scholar profile)
Peer-reviewed journal articles
  1. Influence of protein crowder size on hydration structure and dynamics in macromolecular crowding.

    Po-hung Wang, Isseki Yu, Michael Feig, and Yuji Sugita.
    Chem. Phys. Lett., 671, 63-70 (2017).

  2. Identification of mutation hot-spots for substrate diffusion in proteins.

    David De Sancho, Adam Kubas, Po-hung Wang, Jochen Blumberger, and Robert B. Best.
    J. Chem. Theory Comput., 11, 1919-1927 (2015).

  3. Combining experimental and theoretical methods to learn about the reactivity of gas-processing metalloenzymes.

    Claudio Greco, Vincent Fourmond, Carole Baffert, Po-hung Wang, Sébastien Dementin, Patrick Bertrand, Maurizio Bruschi, Jochen Blumberger, Luca De Gioia, and Christophe Léger.
    Energy Environ. Sci., 7, 3543-3573 (2014).

  4. The oxidative inactivation of FeFe hydrogenase reveals the flexibility of the H-cluster.

    Vincent Fourmond, Claudio Greco, Kateryna Sybirna, Carole Baffert, Po-hung Wang, Pierre Ezanno, Marco Montefiori, Maurizio Bruschi, Isabelle Meynial-Salles, Philippe Soucaille, Jochen Blumberger, Hervé Bottin, Luca De Gioia, and Christophe Léger.
    Nat. Chem., 6, 336-342 (2014).

  5. Uncovering a dynamically formed substrate access tunnel in carbon monoxide dehydrogenase/acetyl-CoA synthase.

    Po-hung Wang, Maurizio Bruschi, Luca De Gioia, and Jochen Blumberger.
    J. Am. Chem. Soc., 135, 9493-9502 (2013).

  6. Mechanistic insight into the blocking of CO diffusion in [NiFe]-hydrogenase mutants through multiscale simulation.

    Po-hung Wang and Jochen Blumberger.
    Proc. Natl. Acad. Sci. USA, 109, 6399-6404 (2012).

  7. A microscopic model for gas diffusion dynamics in a [NiFe]-hydrogenase.

    Po-hung Wang, Robert B. Best, and Jochen Blumberger.
    Phys. Chem. Chem. Phys., 13, 7708-7719 (2011).

  8. Multiscale simulation reveals multiple pathways for H2 and O2 transport in a [NiFe]-hydrogenase.

    Po-hung Wang, Robert B. Best, and Jochen Blumberger.
    J. Am. Chem. Soc., 133, 3548-3556 (2011).


Book chapters

  1. Chapter thirteen - Computation of rate constants for diffusion of small ligands to and from buried protein active sites.
    in Computational Approaches for Studying Enzyme Mechanism Part B, Gregory A. Voth (ed.) (Elsevier).

    Po-hung Wang, David De Sancho, Robert B. Best, and Jochen Blumberger.
    Methods Enzymol., 578, 299-326 (2016).

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