Ph. D in Chemistry, The University of Texas at Austin, USA
2001
M.S. in Chemistry, National Taiwan University, Taiwan
1999
B.S. in Chemistry, National Taiwan University, Taiwan
RESEARCH AND TEACHING EXPERIENCES
2009-present
Postdoctoral Research Associate, RIKEN Research Center for Allergy and Immunology, Japan
2006-2009
Postdoctoral Research Associate, Department of Biomedical Engineering, Washington University in St. Louis, USA
2003-2004
Teaching Assistant, Department of Chemistry and Biochemistry, University of Texas at Austin
2001-2002
Research Assistant, Institute of Chemistry, Academia Sinica, Taiwan
PROFESSIONAL AFFILIATIONS
RESEARCH PROJECTS
Structure prediction of transmembrane proteins Modulator of Immune Recognition 1 and 2 from Kaposi's sarcoma-associated herpesvirus, and theoretical investigation of their recognition mechanism for the human immune-related transmembrane proteins. Methodology development of (replica exchange) multidimensional umbrella sampling method for the study of transmembrane proteins recognitions.
PUBLICATIONS
Pai-Chi Li, Mizuho Kajikawa, Naoyuki Miyashita, Satoshi Ishido, and Yuji Sugita, "Molecular Mechanisms for the Recognition of MHC I by MIR2 from Kaposi's Sarcoma-Associated Herpesvirus." Under review.
Pai-Chi Li, Naoyuki Miyashita, Wonpil Im, Satoshi Ishido, and Yuji Sugita. "Multidimensional umbrella sampling and replica-exchange molecular dynamics simulations for structure prediction of transmembrane helix dimers." Journal of Computational Chemistry, 2014, 35, 300.
Yuji Sugita, Naoyuki Miyashita, Pai-Chi Li, Takao Yoda, Yuko Okamoto. " Recent Applications of Replica-Exchange Molecular Dynamics Simulations of Biomolecules." Current Physical Chemistry, 2012, 2, 401
Mizuho Kajikawa, Pai-Chi Li, Eiji Goto, Naoyuki Miyashita, Masami Aoki-Kawasumi, Mari Mito-Yoshida, Mika Ikegaya, Yuji Sugita, and Satoshi Ishido."Inter-transmembrane region of KSHV MIR2 contributes to B7-2 downregulation." Journal of Virology, 2012,86,5288.
Pai-Chi Li, Lei Huang and Dmitrii E. Makarov, "Mechanical unfolding of segment-swapped protein G dimer: Results from replica exchange molecular dynamics simulation. " J. Phys. Chem. B, 2006, 110 , 14469.
Pai-Chi Li and Dmitrii E. Makarov, "Simulation of the mechanical unfolding of ubiquitin: Probing different unfolding reaction coordinates by changing the pulling geometry." J. Chem. Phys., 2004, 121, 4826.
Pai-Chi Li and Dmitrii E. Makarov, "Ubiquitin-like protein domains show high resistance to mechanical unfolding similar to that of the I27 domain in titin: Evidence from simulations." J. Phys. Chem. B, 2004, 108, 745.
Pai-Chi Li and Dmitrii E. Makarov, "Theoretical studies of the mechanical unfolding of the muscle protein titin: Bridging the time-scale gap between simulation and experiment." J. Chem. Phys, 2003, 119, 9260.
Kilho Eom, Pai-Chi Li, Dmitrii E. Makarov, and Gregory J. Rodin, "Relationship between the mechanical properties and topology of cross-linked polymer molecules: Parallel strands maximize the strength of model polymers and protein domains." J. Phys. Chem. B, 2003, 107, 8730.
Gholam H. Hakimelahi, Pai-Chi Li, Ali A. Moosavi-Movahedi, Jamshid Chamani, Ghadam A, Khodarahmi, Tai Wei Ly, Famil Valiyev, Max K. Leong, Shahram, Hakimelahi, Kak-Shan Shia, Ito Chao, "Application of the Barton photochemical reaction in the synthesis of 1-dethia-3-aza-1-carba-2-oxacephem: a novel agent against resistant pathogenic microorganisms." Organic & Biomolecular Chemistry 2003, 1, 2461.
Pai-Chi Li, Tsung-Shing Wang, Gen-Hsian Lee, Yi-Hong Liu, Yu Wang, Chao-Tsen Chen, Ito Chao, "Theoretical Study and X-ray Determination of [Research and teaching experiences]:Bianthrones: Long C-C Bond Length and Preferred Gauche Conformation." J. Org. Chem. 2002, 67, 8002.
