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研究業績

原著論文 2000-

2019

  • Sakai, Y., T. Hirano and M. Tachikawa. (2019). Molecular dynamics simulations of condensin-mediated mitotic chromosome assembly. Methods Mol Biol. 2004:319-334.
    PMID: 31147926
  • Hara, K., K. Kinoshita, T. Migita, K. Murakami, K. Simizu, K. Takeuchi, T. Hirano and H. Hashimoto. (2019). Structural basis of HEAT-kleisin interactions in the human condensin I subcomplex. EMBO Rep. 20:e47183.
    PMID: 30858338

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2018

  • Shintomi, K. and T. Hirano. (2018). Reconstitution of mitotic chromatids in vitro. Curr Protoc Cell Biol. 79:e48.
    PMID: 29924489
  • Sakai, Y., A. Mochizuki, K. Kinoshita, T. Hirano and M. Tachikawa. (2018). Modeling the functions of condensin in chromosome shaping and segregation. PLoS Comput Biol. 14:e1006152.
    PMID: 29912867
  • Takagi, M., T. Ono, T. Natsume, C. Sakamoto, M. Nakao, N. Saitoh, M. T. Kanemaki, T. Hirano and N. Imamoto. (2018). Ki-67 and condensins support the integrity of mitotic chromosomes through distinct mechanisms. J Cell Sci. 131: jcs212092 doi: 10.1242.
    PMID: 29487178

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2017

  • Shintomi, K. and T. Hirano. (2017). Mitotic chromosome assembly in vitro: functional cross talk between nucleosomes and condensins. Cold Spring Harb Symp Quant Biol. pii: 033639. doi: 10.1101/sqb.2017.82.033639.
    PMID: 29118204
  • Hirano, T., T. Nishiyama and K. Shirahige. (2017). Hot debate in hot springs: Report on the second international meeting on SMC proteins. Genes Cells. 22:934-938.
    PMID: 29067760
  • Hirano, T. (2017). Capturing condensin in chromosomes. Nat Genet. 49:1419-1420.
    PMID: 28951628
  • Ono, T., C. Sakamoto, M. Nakao, N. Saitoh and T. Hirano. (2017). Condensin II plays an essential role in reversible assembly of mitotic chromosomes in situ. Mol Biol Cell. 28:2875-2886.
    PMID: 28835373
  • Shintomi, K., F. Inoue, H. Watanabe, K. Ohsumi, M. Ohsugi and T. Hirano. (2017). Mitotic chromosome assembly despite nucleosome depletion in Xenopus egg extracts. Science. 356:1284-1287.
    PMID: 28522692
  • Kamada, K., M. Su'etsugu, H. Takada, M. Miyata and T. Hirano. (2017). Overall shapes of the SMC-ScpAB complex are determined by balance between constraint and relaxation of its structural parts. Structure. 25:603-616.
    PMID: 28286005
  • Kinoshita, K. and T. Hirano. (2017). Dynamic organization of mitotic chromosomes. Curr Opin Cell Biol. 46:46-53.
    PMID: 28214612
  • Shintomi, K. and T. Hirano. (2017). A sister chromatid cohesion assay using Xenopus egg extracts. Methods Mol Biol. 1515:3-21.
    PMID: 27797070

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2016

  • Yoshimura, S. H. and T. Hirano. (2016). HEAT repeats – versatile arrays of amphiphilic helices working in crowded environments? J Cell Sci. 129: 3963-3970.
    PMID: 27802131
  • Hirano, T. (2016). Condensin-based chromosome organization from bacteria to vertebrates. Cell. 164:847-857.
    PMID: 26919425

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2015

  • Shintomi, K., T. S. Takahashi, and T. Hirano. (2015). Reconstitution of mitotic chromatids with a minimum set of purified factors. Nat Cell Biol. 17:1014-1023.
    PMID: 26075356
  • Sutani, T., T. Sakata, R. Nakato, K. Matsuda, M. Ishibashi, D. Yamashita, Y. Suzuki, T. Hirano, M. Bando, and K. Shirahige. (2015). Condensin targets and reduces unwound DNA structure associated with transcription in mitotic chromosome condensation. Nat Commun. 6:7815.
    PMID: 26204128
  • Houlard, M., J. Godwin, J. Metson, J. Lee, T. Hirano and K. Nasmyth. (2015). Condensin confers the longitudinal rigidity of chromosomes. Nat Cell Biol. 17:771-781.
    PMID: 25961503
  • Hirano, T. (2015). Chromosome dynamics during mitosis. Cold Spring Harb. Perspect. Biol. doi:10.1101/cshperspect.a015792.
    PMID: 25722466
  • Kinoshita, K., T. J. Kobayashi and T. Hirano. (2015). Balancing acts of two HEAT subunits of condensin I support dynamic assembly of chromosome axes. Dev Cell. 33:94-106.
    PMID: 25850674
  • Arroyo, M., M. Trimborn, A. Sanchez, T. Hirano, H. Neitzel and J. A. Marchal. (2015). Chromosome structure deficiencies in MCPH1 syndrome. Chromosoma. 124:491-501.
    PMID: 25845520

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2014

  • Nishide, K. and T. Hirano. (2014). Overlapping and non-overlapping functions of condensins I and II in neural stem cell divisions. PLoS Genet. 10:e1004847. 著者による解説
    PMID: 25474630
  • Fujiwara, T. and T. Hirano. (2014). Specific contribution of condensin II to sister centromere resolution in Cyanidioschyzon merolae. In Atlas of Plant Cell Structure, Noguchi et al. ed. Springer, pp. 20.
  • Hirano, T. (2014). Condensins and the evolution of torsion-mediated genome organization. Trends Cell Biol. 24:727-733.
    PMID: 25092191
  • Nakagawa, S. and T. Hirano. (2014). Gathering around Firre. Nat Struct Mol Biol 21:207-208.
    PMID: 24599247

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2013

  • Fujiwara, T., M. Ohnuma, M. Yoshida, T. Kuroiwa and T. Hirano. (2013). Gene targeting in the red alga Cyanidioschyzon merolae: single- and multi-copy insertions using authentic and chimeric selection markers. PLoS One. 8:e73608.
    PMID: 24039997
  • Fujiwara, T., K. Tanaka, T. Kuroiwa and T. Hirano. (2013). Spatiotemporal dynamics of condensins I and II: evolutionary insights from the primitive red alga Cyanidioschyzon merolae. Mol Biol Cell. 24:2515-2527.
    PMID: 23783031
  • Kamada, K., M. Miyata and T. Hirano. (2013). Molecular basis of SMC ATPase activation: role of internal structural changes of the regulatory subcomplex ScpAB. Structure. 21:581-594.
    PMID: 23541893
  • Ono, T., D. Yamashita and T. Hirano. (2013). Condensin II initiates sister chromatid resolution during S phase. J Cell Biol. 200:429-441.
    PMID: 23401001

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2012

  • Shiheido, H., Y. Naito, H. Kimura, H. Genma, H. Takashima, T. Ono, T. Hirano, W. Du, T. Yamada, N. Doi, S. Iijima, Y. Hattori and H. Yanagawa. (2012). An anilinoquinazoline derivative inhibits tumor growth through interaction with hCAP-G2, a subunit of condensin II. PLoS One. 7:e44889.
    PMID: 23028663
  • Hirano, T. (2012). Chromosome territories meet a condensin. PLoS Genet. 8:e1002939.
    PMID: 22956917
  • Hirano, T. (2012). Condensins: universal organizers of chromosomes with diverse functions. Genes Dev. 26:1659-1678.
    PMID: 22855829

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2011

  • Yamashita, D., K. Shintomi, T. Ono, I. Gavvovidis, D. Schindler, H. Neitzel, M. Trimborn and T. Hirano. (2011). MCPH1 regulates chromosome condensation and shaping as a composite modulator of condensin II. J Cell Biol. 194:841-854.
    PMID: 21911480
  • Lee, J., S. Ogushi, M. Saitou and T. Hirano. (2011). Condensin I and II are essential for construction of bivalent chromosomes in mouse oocytes. Mol Biol Cell. 22:3465-3477.
    PMID: 21795393
  • Shintomi, K. and T. Hirano. (2011). The relative ratio of condensin I to II determines chromosome shapes. Genes Dev. 25:1464-1469.
    PMID: 21715560
  • Lee, J. and T. Hirano. (2011). RAD21L, a novel cohesin subunit implicated in linking homologous chromosomes in mammalian meiosis. J Cell Biol. 192:263-276.
    PMID: 21242291

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2010

  • Gavvovidis, I., C. Pöhlmann, J. A. Marchal, M. Stumm, D. Yamashita, T. Hirano, D. Schindler, H. Neitzel and M. Trimborn. (2010). MCPH1 patient cells exhibit delayed release from DNA damage-induced G2/M checkpoint arrest. Cell Cycle. 9:4893-4899.
    PMID: 21150325
  • Hirano, T. (2010). How to separate entangled sisters: interplay between condensin and decatenase. Proc Natl Acad Sci USA. 107:18749-18750.
    PMID: 20962275
  • Shintomi, K. and T. Hirano. (2010). Sister chromatid resolution: a cohesion releasing network and beyond. Chromosoma. 119:459-467.
    PMID: 20352243

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2009

  • Takemoto, A., K. Maeshima, T. Ikehara, K. Yamaguchi, A. Murayama, S. Imamura, N. Imamoto, S. Yokoyama, T. Hirano, Y. Watanabe, F. Hanaoka, J. Yanagisawa and K. Kimura. (2009). The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A. Nat Struct Mol Biol. 16:1302-1308.
    PMID: 19915589
  • Shintomi, K. and T. Hirano. (2009). Releasing cohesin from chromosome arms in early mitosis: opposing actions Wapl-Pds5 and Sgo1. Genes Dev. 23:2224-2236.
    PMID: 19696148
  • Hirano, T. (2009). Let's play polo in the field of condensation. Mol Cell. 34:399-401.
    PMID: 19481518

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2007

  • Shintomi, K. and T. Hirano. (2007). How are cohesin rings opened and closed? Trends Biochem Sci. 32:154–157.
    PMID: 17320400
  • Onn, I., N. Aono, M. Hirano and T. Hirano. (2007). Reconstitution and subunit geometry of human condensin complexes. EMBO J. 26:1024–1034.
    PMID: 17268547

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2006

  • Gandhi, R., P. J. Gillespie and T. Hirano. (2006). Human Wapl is a cohesin-binding protein that promotes sister chromatid resolution in mitotic prophase. Curr Biol. 16:2406-2417.
    PMID: 17112726
  • Hirano, T. (2006). At the heart of the chromosome: SMC proteins in action. Nat Rev Mol Cell Biol. 7:311-322.
    PMID: 16633335
  • Trimborn, M., D. Shindler, H. Neitzel and T. Hirano. (2006). Misregulated chromosome condensation in MCPH1 microcephaly is mediated by condensin II. Cell Cycle. 5:322-326.
    PMID: 16434882
  • Hirano, M. and T. Hirano. (2006). Opening closed arms: long-distance activation of SMC ATPase by hinge-DNA interactions. Mol Cell. 21:175-186.
    PMID: 16427008

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2005

  • Losada, A. and T. Hirano. (2005). Dynamic molecular linkers of the genome: the first decade of SMC proteins. Genes Dev. 19:1269-1287.
    PMID: 15937217
  • Losada, A., T. Yokochi and T. Hirano. (2005). Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts. J Cell Sci. 118:2133-2141.
    PMID: 15855230
  • Hirano, T. (2005). SMC proteins and chromosome mechanics: from bacteria to humans. Philos Trans R Soc Lond B Biol Sci. 360:507-514.
    PMID: 15897176
  • Hirano, T. (2005). Condensins: organizing and segregating the genome. Curr Biol. 15:R265-R275.
    PMID: 15823530
  • Hirano, T. (2005). Holding sisters for repair. Nature. 433:467-468.
    PMID: 15690020

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2004

  • Kireeva, N., M. Lakonishok, I. Kireev, T. Hirano and A. S. Belmont. (2004). Visualization of early chromosome condensation: a hierarchical folding, axial glue model of chromosome structure. J Cell Biol. 166:775-785.
    PMID: 15353545
  • Gillespie, P. J. and T. Hirano. (2004). Scc2 couples replication licensing to sister chromatid cohesion in Xenopus egg extracts. Curr Biol. 14:1598-1603.
    PMID: 15341749
  • Hirano, M. and T. Hirano. (2004). Positive and negative regulation of SMC-DNA interactions by ATP and accessory proteins. EMBO J. 23:2664-2673.
    PMID: 15175656
  • Ono, T., Y. Fang, D. L. Spector and T. Hirano. (2004). Spatial and temporal regulation of condensins I and II in mitotic chromosome assembly in human cells. Mol Biol Cell. 15:3296-3308.
    PMID: 15146063
  • Strick, T., T. Kawaguchi and T. Hirano. (2004). Real-time detection of single-molecule DNA compaction by condensin I. Curr Biol. 14:874-880.
    PMID: 15186743
  • Almagro, S., D. Riveline, T. Hirano, B. Houchmandzadeh and S. Dimitrov. (2004). The mitotic chromosome: an assembly of rigid elastic axes, organized by SMC proteins and surrounded by a soft chromatin envelope. J Biol Chem. 279:5118-5126.
    PMID: 14660618
  • Hirano, T. (2004). Chromosome shaping by two condensins. Cell Cycle. 3:26-28.
    PMID: 14657659

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2003

  • Ono, T., A. Losada, M. Hirano, M. P. Myers, A. F. Neuwald and T. Hirano. (2003). Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells. Cell. 115:109-121.
    PMID: 14532007
  • Almagro, S., S. Dimitrov, T. Hirano, M. Vallade and D. Riveline. (2003). Individual chromosomes as viscoelastic copolymers. Europhys. Lett. 63:908-914.
  • Swedlow, J. R. and T. Hirano. (2003). The making of the mitotic chromosome: modern insights into classical questions. Mol Cell. 11:557-569.
    PMID: 12667441
  • Cuvier, O. and T. Hirano. (2003). A role of topoisomerase II in linking DNA replication to chromosome condensation. J Cell Biol. 160:645-655.
    PMID: 12604590

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2002

  • Losada, A., M. Hirano and T. Hirano. (2002). Cohesin release is required for sister chromatid resolution, but not for condensin-mediated compaction, at the onset of mitosis. Genes Dev. 16:3004-3016.
    PMID: 12464631
  • Hirano, M. and T. Hirano. (2002). Hinge-mediated dimerization of SMC protein is essential for its dynamic interaction with DNA. EMBO J. 21:5733-5744.
    PMID: 12411491
  • Gillespie, P. J. and T. Hirano. (2002). SMC proteins. Curr Biol. 12:R513.
    PMID: 12176371
  • Bazett-Jones, D. P., K. Kimura and T. Hirano. (2002). Efficient supercoiling of DNA by a single condensin complex as revealed by electron spectroscopic imaging. Mol Cell. 9:1183-1190.
    PMID: 12086616
  • Eide, T., C. Carlson, K. A. Tasken, T. Hirano, K. Tasken and P. Collas. (2002). Distinct but overlapping domains of AKAP95 are implicated in chromosome condensation and condensin targeting. EMBO Rep. 3:426-432.
    PMID: 11964380
  • Hirano, T. (2002). The ABCs of SMC proteins: two-armed ATPases for chromosome condensation, cohesion and repair. Genes Dev. 16:399-414.
    PMID: 11850403
  • Anderson, D. E., A. Losada, H. P. Erickson and T. Hirano. (2002). Condensin and cohesin display different arm conformations with characteristic hinge angles. J Cell Biol. 156:419-424.
    PMID: 11815634
  • MacCallum, D. E., A. Losada, R. Kobayashi and T. Hirano. (2002). ISWI remodeling complexes in Xenopus egg extracts: identification as major chromosomal components that are regulated by INCENP-aurora B. Mol Biol Cell. 13:25-39.
    PMID: 11809820

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2001

  • Losada, A. and T. Hirano. (2001). Shaping the metaphase chromosome: coordination of cohesion and condensation. BioEssays. 23:924-935.
    PMID: 11598959
  • Hirano, M., D. E. Anderson, H. P. Erickson and T. Hirano. (2001). Bimodal activation of SMC ATPase by intra- and inter-molecular interactions. EMBO J. 20:3238-3250.
    PMID: 11406600
  • Losada, A. and T. Hirano. (2001). Intermolecular DNA interactions stimulated by the cohesin complex in vitro: implications for sister chromatid cohesion. Curr Biol. 11:268-272.
    PMID: 11250156
  • Kimura, K., O. Cuvier and T. Hirano. (2001). Chromosome condensation by a human condensin complex in Xenopus egg extracts. J Biol Chem. 276:5417-5420.
    PMID: 11136719

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2000

  • Kimura, K. and T. Hirano. (2000). Dual roles of the 11S regulatory subcomplex in condensin functions. Proc Natl Acad Sci USA. 97:11972-11977.
    PMID: 11027308
  • Neuwald, A. F. and T. Hirano. (2000). HEAT repeats associated with condensins, cohesins and other chromosome-related complexes. Genome Res. 10:1445-1452.
    PMID: 11042144
  • Losada, A. and T. Hirano. (2000). New light on sticky sisters. Curr. Biol. 10:R615.
    PMID: 10996082
  • Hirano, T. (2000). Chromosome cohesion, condensation and separation. Annu Rev Biochem. 69:115-144.
    PMID: 10966455
  • Losada, A., T. Yokochi, R. Kobayashi and T. Hirano. (2000). Identification and characterization of SA/Scc3p subunits in the Xenopus and human cohesin complexes. J Cell Biol. 150:405-416.
    PMID: 10931856

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独立行政法人 理化学研究所 平野染色体ダイナミクス研究室 〒351-0198 埼玉県和光市広沢2-1
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