新冨 圭史 （しんとみ けいし）
研究の興味
ゲノムの複製と分配の制御メカニズムとその初期胚における特殊性
学歴
| 2000 |
東京工業大学生命理工学部生体機構学科卒業 |
| 2005 |
東京工業大学大学院生命理工学研究科生命情報専攻博士課程修了（博士（理学）取得） |
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研究歴／職歴
| 2005-07 |
米国コールド・スプリング・ハーバー研究所 Postdoctoral Fellow |
| 2007-11 |
理化学研究所 博士研究員 |
| 2011-18 |
理化学研究所 研究員 |
| 2018-現在 |
理化学研究所 専任研究員 |
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受賞・学会活動等
| 2007-10 |
理化学研究所基礎科学特別研究員（フェローシップ） |
| 2008 |
理化学研究所研究奨励ファンド |
| 2010 |
理化学研究所研究奨励賞 |
| 2003- |
日本分子生物学会会員 |
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発表論文
- Shintomi, K., Y. Masahara-Negishi, M. Shima, S. Tane and T. Hirano. (2024). Recombinant cyclin B-Cdk1-Suc1 capable of multi-site mitotic phosphorylation in vitro. PLoS One. 19:e0299003.
PMID: 38527022
- Yoshida, M. M., K. Kinoshita, K. Shintomi, Y. Aizawa and T. Hirano. (2024). Regulation of condensin II by self-suppression and release mechanisms. Mol Biol Cell. 35:ar21.
PMID: 38088875
- Sun, M., H. Amiri, A. B. Tong, K. Shintomi, T. Hirano, C. Bustamante and R. Heald. (2023). Monitoring the compaction of single DNA molecules in Xenopus egg extract in real time. Proc Natl Acad Sci USA. 120:e2221309120.
PMID: 36917660
- Fukuda, Y., K. Shintomi, K. Yamaguchi, Y. Fujiwara and Y. Okada. (2023). Solubilization of mouse sperm chromatin for sequencing analyses using a chaperon protein. Methods Mol Biol. 2577:161-173.
PMID: 36173572
- Tane, S., K. Shintomi, K. Kinoshita, Y. Tsubota, M. M. Yoshida, T. Nishiyama and T. Hirano. (2022). Cell cycle-specific loading of condensin I is regulated by the N-terminal tail of its kleisin subunit. eLife. 11:e84694.
PMID: 36511239
- Yoshida, M. M., K. Kinoshita, Y. Aizawa, S. Tane, D. Yamashita, K. Shintomi and T. Hirano. (2022). Molecular dissection of condensin II-mediated chromosome assembly using in vitro assays. eLife. 11:e78984.
PMID: 35983835
- Shintomi, K. (2022). Making mitotic chromosomes in a test tube. Epigenomes. 6:20.
PMID: 35893016
- Kinoshita, K., Y. Tsubota, S. Tane, Y. Aizawa, R. Sakata, K. Takeuchi, K. Shintomi, T. Nishiyama and T. Hirano. (2022). A loop extrusion-independent mechanism contributes to condensin I-mediated chromosome shaping. J Cell Biol. 221:e202109016.
PMID: 35045152
- Shintomi, K. and T. Hirano. (2021). Guiding functions of the C-terminal domain of topoisomerase IIα advance mitotic chromosome assembly. Nat Commun. 12:2917.
PMID: 34006877
- Shintomi, K. and T. Hirano. (2018). Reconstitution of mitotic chromatids in vitro. Curr Protoc Cell Biol. 79:e48.
PMID: 29924489
- Shintomi, K. and T. Hirano. (2017). Mitotic chromosome assembly in vitro: functional cross talk between nucleosomes and condensins. Cold Spring Harb Symp Quant Biol. pii: 033639. doi: 10.1101/sqb.2017.82.033639.
PMID: 29118204
- Shintomi, K., F. Inoue, H. Watanabe, K. Ohsumi, M. Ohsugi and T. Hirano. (2017). Mitotic chromosome assembly despite nucleosome depletion in Xenopus egg extracts. Science. 356:1284-1287.
PMID: 28522692
- Shintomi, K. and T. Hirano. (2017). A sister chromatid cohesion assay using Xenopus egg extracts. Methods Mol Biol. 1515:3-21.
PMID: 27797070
- Shintomi, K., T. S. Takahashi, and T. Hirano. (2015). Reconstitution of mitotic chromatids with a minimum set of purified factors. Nat Cell Biol. 17:1014-1023.
PMID: 26075356
- Yamashita, D., K. Shintomi, T. Ono, I. Gavvovidis, D. Schindler, H. Neitzel, M. Trimborn and T. Hirano. (2011). MCPH1 regulates chromosome condensation and shaping as a composite modulator of condensin II. J Cell Biol. 194:841-854.
PMID: 21911480
- Shintomi, K. and T. Hirano. (2011). The relative ratio of condensin I to II determines chromosome shapes. Genes Dev. 25:1464-1469.
PMID: 21715560
- Shintomi, K. and T. Hirano. (2010). Sister chromatid resolution: a cohesion releasing network and beyond. Chromosoma. 119:459-467.
PMID: 20352243
- Shintomi, K. and T. Hirano. (2009). Releasing cohesin from chromosome arms in early mitosis: opposing actions Wapl-Pds5 and Sgo1. Genes Dev. 23:2224-2236.
PMID: 19696148
- Shintomi, K. and T. Hirano. (2007). How are cohesin rings opened and closed? Trends Biochem Sci. 32:154–157.
PMID: 17320400
- Shintomi K., M. Iwabuchi, H. Saeki, K. Ura, T. Kishimoto and K. Ohsumi. (2005). Nucleosome assembly protein-1 is a linker histone chaperone in Xenopus eggs. Proc Natl Acad Sci U S A. 102:8210–8215.
PMID: 15928086
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