李 智博 （り ともひろ）
研究の興味
哺乳類減数分裂における染色体動態の制御機構
学歴
| 1995 | 神戸大学農学部畜産学科卒業 |
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| 1997 | 神戸大学大学院自然科学研究科応用動物学専攻博士前期課程修了 |
| 2000 | 神戸大学大学院自然科学研究科生命機能科学専攻博士後期課程修了 （博士（農学）取得）、在籍中に英国Babraham研究所に20ヶ月留学 |
研究歴／職歴
| 2000 | 北海道大学大学院理学研究科 日本学術振興会特別研究員 |
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| 2003-07 | 神戸大学大学院自然科学研究科 COE研究員 |
| 2007-現在 | 独立行政法人理化学研究所 基幹研究所 博士研究員（協力研究員） |
受賞・学会活動等
| 2000 | 日本学術振興会特別研究員 |
|---|---|
| 2004-06 | 科学研究費補助金（若手研究(B)） |
| 2008- | 科学研究費補助金（若手研究(B)） |
| 2004- | 日本繁殖生物学会会員 |
| 2006- | 日本分子生物学会会員 |
発表論文
- Tate S., K. Nakamura, C. Suzuki, T. Noda, J. Lee and H. Harayama. (2010). Evidence of the existence of adenylyl cyclase 10 (ADCY10) ortholog proteins in the heads and connecting pieces of boar spermatozoa. J Reprod Dev. in press.
PMID: 20103986 - Moniruzzaman M., J. Lee, M. Zengyo and T. Miyano. (2009). Knockdown of FOXO3 induces primordial oocyte activation in pigs. Reproduction. 139:1-13.
PMID: 19884171 - Lee J., T. S. Kitajima, Y. Tanno, K. Yoshida, T. Morita, T. Miyano, M. Miyake and Y. Watanabe. (2008). Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells. Nat Cell Biol. 10:42-52.
PMID: 18084284 - Sakai C., F. Konno, O. Nakano, T. Iwai, T. Yokota, J. Lee, C. Nishida-Umehara, A. Kuroiwa, Y. Matsuda and M. Yamashita. (2007). Chromosome elimination in the interspecific hybrid medaka between Oryzias latipes and O. hubbsi. Chromosome Res. 15:697-709.
PMID: 17603754 - Amano R., J. Lee, N. Goto and H. Harayama. (2007). Evidence for existence of cAMP-Epac signaling in the heads of mouse epididymal spermatozoa, J Reprod Dev. 53:127-133.
PMID: 17077580 - Lee J., K. Okada, S. Ogushi, T. Miyano, M. Miyake and M. Yamashita. (2006). Loss of Rec8 from chromosome arm and centromere region is required for homologous chromosome separation and sister chromatid separation, respectively, in mammalian meiosis. Cell Cycle. 5:1448-1455.
PMID: 16855401 - Iwai T., J. Lee, A. Yoshii, T. Yokota, K. Mita and M. Yamashita. (2004). Changes in the expression and localization of cohesin subunits during meiosis in a non-mammalian vertebrate, the medakafish. Gene Expr Patterns. 4:495-504.
PMID: 15261826 - Lee J., T. Iwai, T. Yokota and M. Yamashita. (2003). Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis. J Cell Sci. 116:2781-2790.
PMID: 12759374 - Lee J., T. Yokota and M. Yamashita. (2002). Analyses of mRNA expression patterns of cohesin subunits Rad21 and Rec8 in mice: Germ cell-specific expression of rec8 mRNA in both male and female mice. Zool Sci. 19:539-544.
PMID: 12130806 - Kanayama N., T. Miyano and J. Lee. (2002). Acquisition of meiotic competence in growing pig oocytes correlates with their ability to activate Cdc2 kinase and MAP kinase. Zygote. 10:261-270.
PMID: 12214808 - Miyano T., Y. Dai, J. Lee, K. Kano and R. M. Moor. (2000). Degradation of pig cyclin B1 molecules precedes MAP kinase dephosphorylation during fertilisation of the oocytes. Zygote. 8:153-158.
PMID: 10857586 - Lee J., T. Miyano and R. M. Moor. (2000). Localisation of phosphorylated MAP kinase during the transition from meiosis I to meiosis II in pig oocytes. Zygote. 8:119-125.
PMID: 10857582 - Lee J., T. Miyano, Y. Dai, P. Wooding, T. J. Yen and R. M. Moor. (2000). Specific regulation of CENP-E and kinetochores during meiosis I / meiosis II transition in pig oocytes. Mol Reprod Dev. 56:51-62.
PMID: 10737967 - Lee J., T. Miyano and R. M. Moor. (2000). Spindle formation and dynamics of γ-tubulin and NuMA distribution during meiosis in pig and mouse oocytes. Biol Reprod. 62:1184-1192.
PMID: 10775165
