Publications by Hiroshi Sugimoto, Ph.D.
[2023]
- Suzuki, K., Stanfield, J.K., Omura, K., Shisaka, Y., Ariyasu, S., Kasai, C., Aiba, Y., Sugimoto, H., Shoji, O., “A compound I mimic reveals the transient active species of a cytochrome P450 Enzyme: insight into the stereoselectivity of P450-catalysed oxidations”, Angew. Chem. Int. Ed., 62, e202381362 (2023) [doi]
[2022]
- Lučić, M., Wilson, M.T., Tosha, T., Sugimoto, H., Shilova, A., Axford, D., Owen, R.L., Hough, M.A., Worrall, J.A.R., “Serial Femtosecond Crystallography Reveals the Role of Water in the One- or Two-Electron Redox Chemistry of Compound I in the Catalytic Cycle of the B-Type Dye-Decolorizing Peroxidase DtpB”, ACS Catal., 12, 13349-13359 (2022) [doi]
- Moreno-Chicano, T., Carey, L.M., Axford, D., Beale, J.H., Doak, R.B., Duyvesteyn, H.M.E., Ebrahim, A., Henning, R.W., Monteiro, D.C.F., Myles, D.A., Owada, S., Sherrell, D.A., Straw, M.L., Srajer, V., Sugimoto, H., Tono, K., Tosha, T., Tews, I., Trebbin, M., Strange, R.W., Weiss, K.L., Worrall, J.A.R., Meilleur, F., Owen, R.L., Ghiladi, R.A., Hough, M.A., “Complementarity of neutron, XFEL and synchrotron crystallography for defining the structures of metalloenzymes at room temperature”, IUCrJ, 9, 610-624 (2022) [doi]
- Shisaka, Y., Sakakibara, E., Suzuki, K., Stanfield, J.K., Onoda, H., Ueda, G., Hatano, M., Sugimoto, H., Shoji, O., “Tetraphenylporphyrin Enters the Ring: First Example of a Complex Between Highly Bulky Porphyrins and a Protein”, ChemBioChem, e202200095 (2022) [doi]
- Yogo, Y., Yasuda, K., Takita, T., Yasukawa, K., Iwai, Y., Nishikawa, M., Sugimoto, H., Ikushiro, S., Sakaki, T. "Metabolism of non-steroidal anti-inflammatory drugs (NSAIDs) by Streptomyces griseolus CYP105A1 and its variants". Drug Metab. Pharmacokinet. 100455 (2022) [doi]
- Takiguchi, A., Sakakibara, E., Sugimoto, H., Shoji, O., Shinokubo, H. "A heme-acquisition protein reconstructed with a cobalt 5-oxaporphyrinium cation and its growth-inhibition activity toward multidrug-resistant Pseudomonas aeruginosa". Angew. Chem. Int. Ed. 61, e2021124 (2022) [doi]
[2021]
- Mukai, K., Sugimoto, H., Kamiya, K., Suzuki, R., Matsuura, T., Hishiki, T., Shimada, H., Shiro, Y., Suematsu, M., Kagawa, N. "Spatially restricted substrate-binding site of cortisol-synthesizing CYP11B1 limits multiple hydroxylations and hinders aldosterone synthesis". Curr. Res. Struct. Biol. 3, 192-205 (2021) [doi]
- Nomura, T., Kimura, T., Kanematsu, T., Yamada, D., Yamashita, K., Hirata, K., Ueno, G., Murakami, H., Hisano, T., Yamagiwa, R., Takeda, H., Gopalasingam, C., Kousaka, T., Yanagisawa, S., Shoji, O., Kumasaka, T., Yamamoto, M., Takano, Y., Sugimoto, H., Tosha, T., Kubo, M., Shiro, Y.: "Short-lived intermediate in N2O generation by P450 NO reductase captured by time-resolved IR spectroscopy and XFEL crystallography", Proc. Nat. Acad. Sci. ,118, e2101481118 (2021) [doi]
- Kwon, H., Basran, J., Pathak, C., Hussain, M., Freeman, S. L., Fielding, A. J., Bailey, A. J., Stefanou, N., Sparkes, H. A., Tosha, T., Yamashita, K., Hirata, K., Murakami, H., Ueno, G., Ago, H., Tono, K., Yamamoto, M., Sawai, H., Shiro, Y., Sugimoto, H., Raven, E., Moody, P. C. E.: "XFEL Crystal Structures of Peroxidase Compound II" Angew. Chem. Int. Ed. 60, 14578-14585 (2021) [doi]
- Nishinaga, M., Sugimoto, H., Nishitani, Y., Nagai, S., Nagatoishi, S., Muraki, N., Tosha, T., Tsumoto, K., Aono, S., Shiro, Y., Sawai, H.: "Heme controls the structural rearrangement of its sensor protein mediating the hemolytic bacterial survival" Commun. Biol. 4, 467 (2021) [doi]
[2020]
- Yonemura, K., Ariyasu, S., Stanfield, J.K., Suzuki, K., Onoda, H., Kasai, C., Sugimoto, H., Aiba, Y., Watanabe, Y., Shoji, O., “Systematic Evolution of Decoy Molecules for the Highly Efficient Hydroxylation of Benzene and Small Alkanes Catalyzed by Wild-Type Cytochrome P450BM3”, ACS Catal., 10, 9136-9144 (2020) [doi]
- Lučić, M., Svistunenko, D.A., Wilson, M.T., Chaplin, A.K., Davy, B., Ebrahim, A., Axford, D., Tosha, T., Sugimoto, H., Owada, S., Dworkowski, F.S.N., Tews, I., Owen, R.L., Hough, M.A., Worrall, J.A.R., “Serial Femtosecond Zero Dose Crystallography Captures a Water-Free Distal Heme Site in a Dye-Decolorising Peroxidase to Reveal a Catalytic Role for an Arginine in FeIV=O Formation”, Angew. Chem. Int. Ed., 59, 21656-21662 (2020) [doi]
- Stanfield, J.K., Omura, K., Matsumoto, A., Kasai, C., Sugimoto, H., Shiro, Y., Watanabe, Y., Shoji, O., “Crystals in Minutes: Instant On-Site Microcrystallisation of Various Flavours of the CYP102A1 (P450BM3) Haem Domain”, Angew. Chem. Int. Ed., 59, 7611-7618 (2020) [doi]
- Horitani, M., Kusubayashi, K., Oshima, K., Yato, A., Sugimoto, H., Watanabe, K., “X-ray crystallography and electron paramagnetic resonance spectroscopy reveal active site rearrangement of cold-adapted inorganic pyrophosphatase”, Sci. Rep., 10, 4368 (2020) [doi]
- Suga, M., Shimada, A., Akita, F., Shen, J.R., Tosha, T., Sugimoto, H., “Time-resolved studies of metalloproteins using X-ray free electron laser radiation at SACLA”, Biochim. Biophys. Acta Gen. Subj., 1864, 129466 (2020) [doi]
[2019]
- Moreno-Chicano, T., Ebrahim, A., Axford, D., Appleby, M.V., Beale, J.H., Chaplin, A.K., Duyvesteyn, H.M.E., Ghiladi, R.A., Owada, S., Sherrell, D.A., Strange, R.W., Sugimoto, H., Tono, K., Worrall, J.A.R., Owen, R.L., Hough, M.A., “High-throughput structures of protein-ligand complexes at room temperature using serial femtosecond crystallography”, IUCrJ, 6, 1074-1085 (2019) [doi]
- Pek, R.H., Yuan, X., Rietzschel, N., Zhang, J., Jackson, L., Nishibori, E., Ribeiro, A., Simmons, W., Jagadeesh, J., Sugimoto, H., Alam, M.Z., Garrett, L., Haldar, M., Ralle, M., Phillips, J.D., Bodine, D.M., Hamza, I., “Hemozoin produced by mammals confers heme tolerance”, eLIFE, 8, e49503 (2019) [doi]
- Yanagisawa, S., Kayama, K., Hara, M., Sugimoto, H., Shiro, Y., Ogura, T., “UV resonance Raman characterization of a substrate bound to human indoleamine 2,3-dioxygenase 1”, Biophys. J., 117, 706-716 (2019) [doi]
- Tamura, K., Sugimoto, H., Shiro, Y., Sugita, Y., “Chemo-mechanical coupling in the transport cycle of a heme ABC transporter”, J. Phys. Chem. B, 123, 7270-7281 (2019) [doi]
- Shisaka, Y., Iwai, Y., Yamada, S., Uehara, H., Tosha, T., Sugimoto, H., Shiro, Y., Stanfield, J.K., Ogawa, K., Watanabe, Y., Shoji, O., “Hijacking the heme acquisition system of Pseudomonas aeruginosa for the delivery of phthalocyanine as an antimicrobial”, ACS Chem. Biol., 14, 1637-1642 (2019) [doi]
- Sakakibara, E., Shisaka, Y., Onoda, H., Koga, D., Xu, N., Ono, T., Hisaeda, Y., Sugimoto, H., Shiro, Y., Watanabe, Y., Shoji, O., “Highly malleable haem-binding site of the haemoprotein HasA permits stable accommodation of bulky tetraphenylporphycenes”, RSC Adv., 9, 18697-18702 (2019) [doi]
- Ebrahim, A., Moreno-Chicano, T., Appleby, M.V., Chaplin, A.K., Beale, J.H., Sherrell, D.A., Duyvesteyn, H.M.E., Owada, S., Tono, K., Sugimoto, H., Strange, R.W., Worrall, J.A.R., Axford, D., Owen, R.L., Hough, M.A., “Dose-resolved serial synchrotron and XFEL structures of radiation-sensitive metalloproteins”, IUCrJ, 6, 543-551 (2019) [doi]
- Yoshitani, K., Ishii, E., Taniguchi, K., Sugimoto, H., Shiro, Y., Akiyama, Y., Kato, A., Utsumi, R., Eguchi, Y., “Identification of an internal cavity in the PhoQ sensor domain for PhoQ activity and SafA-mediated control”, Biosci. Biotechnol. Biochem., 83, 684-694 (2019) [doi]
[2018]
- Ganasen, M., Togashi, H., Takeda, H., Asakura, H., Tosha, T., Yamashita, K., Hirata, K., Nariai, Y., Urano, T., Yuan, X., Hamza, I., Mauk, A.G., Shiro, Y., Sugimoto, H., Sawai, H., “Structural basis for promotion of duodenal iron absorption by enteric ferric reductase with ascorbate”, Commun. Biol., 1 120 (2018) [doi]
- Omura, K., Aiba, Y., Onoda, H., Stanfield, J.K., Ariyasu, S., Sugimoto, H., Shiro, Y., Shoji, O., Watanabe, Y., “Reconstitution of full-length P450BM3 with an artificial metal complex by utilising the transpeptidase Sortase A”, Chem. Comm., 54 7892-7895 (2018) [doi]
- Onoda, H., Shoji, O., Suzuki, K., Sugimoto, H., Shiro, Y., Watanabe, Y., “α-Oxidative decarboxylation of fatty acids catalysed by cytochrome P450 peroxygenases yielding shorter-alkyl-chain fatty acids”, Catal. Sci. Technol., 8 434-442 (2018) [doi]
- Yasuda, K., Sugimoto, H., Hayashi, K., Takita, T., Yasukawa, K., Ohta, M., Kamakura, M., Ikushiro, S., Shiro, Y., Sakaki, T., “Protein engineering of CYP105s for their industrial uses”, Biochim. Biophys. Acta Proteins and Proteomics, 1866 23-31 (2018) [doi]
- 杉本宏, 城宜嗣, “ヘム輸送体の立体構造と基質輸送メカニズム”, 生物物理, 335 5-8 (2018) [doi]
[2017]
- Oohora, K., Meichin, H., Kihira, Y., Sugimoto, H., Shiro, Y., Hayashi, T. "Manganese(V) porphycene complex responsible for inert C–H bond hydroxylation in a myoglobin matrix". J. Am. Chem. Soc. 139, 18460-18463 (2017) [doi]
- Tosha, T., Nomura, T., Nishida, T., Saeki, N., Okubayashi, K., Yamagiwa, R., Sugahara, M., Nakane, T., Yamashita, K., Hirata, K., Ueno, G., Kimura, T., Hisano, T., Muramoto, K., Sawai, H., Takeda, H., Mizohata, E., Yamashita, A., Kanematsu, Y., Takano, Y., Nango, E., Tanaka, R., Nureki, O., Shoji, O., Ikemoto, Y., Murakami, H., Owada, S., Tono, K., Yabashi, M., Yamamoto, M., Ago, H., Iwata, S., Sugimoto, H., Shiro, Y., Kubo, M. "Capturing an initial intermediate during the P450nor enzymatic reaction using time-resolved XFEL crystallography and caged-substrate". Nat. Commun. 8, 1585 (2017) [doi]
- Naoe, Y., Nakamura, N., Rahman, M. M., Tosha, T., Nagatoishi, S., Tsumoto, K., Shiro, Y., Sugimoto, H. "Structural basis for binding and transfer of heme in bacterial heme-acquisition systems". Proteins 85, 2217-2230 (2017) [doi]
- Uehara, H., Shisaka, Y., Nishimura, T., Sugimoto, H., Shiro, Y., Miyake, Y., Shinokubo, H., Watanabe, Y., Shoji, O. "Construction and crystal structure analysis of heme proteins containing ion(III)-5, 15-diphenyl-porphyrin and its derivatives as an artificial prosthetic group". Angew. Chem. Int. Ed. i56, 15279-15283 (2017) [PubMed]
- Terasaka, E., Yamada, K., Wang, P. H., Hosokawa, K., Yamagiwa, R., Matsumoto, K., Ishii, S., Mori, T., Yagi, K., Sawai, H., Arai, H., Sugimoto, H., Sugita, Y., Shiro, Y., Tosha, T. "Dynamics of nitric oxide controlled by protein complex in bacterial system" Proc. Natl. Acad. Sci. U.S.A. 114, 9888-9893 (2017) [doi]
- Kaori Yasuda, Hiroshi Sugimoto, Keiko Hayashi, Teisuke Takita, Kiyoshi Yasukawa, Miho Ohta, Masaki Kamakura, Shinichi Ikushiro, Yoshitsugu Shiro, Toshiyuki Sakaki "Protein engineering of CYP105s for their industrial uses" [Review Article] Biochim. Biophys. Acta 1866, 23-31 (2018) [doi]
- Suzuki, K., Stanfield, J. K., Shoji, O., Yanagisawa, S., Sugimoto, H., Shiro, Y., Watanabe, Y. "Control of stereoselectivity of benzylic hydroxylation catalysed by wild-type cytochrome P450BM3 using decoy molecules." Catal. Sci. Technol. 7, 3332-3338 (2017) [doi]
- Shoji, O., Yanagisawa, S., Stanfield, J. K., Suzuki, K., Cong, Z., Sugimoto, H., Shiro, Y., Watanabe, Y., "Direct Hydroxylation of Benzene to Phenol by Cytochrome P450BM3 Triggered by Amino Acid Derivatives." Angew. Chem. Int. Ed. 56, 10324-10329 (2017) [PubMed]
- Yasuda, K., Yogo, Y., Sugimoto, H., Mano, H., Takita, T., Miho Ohta, Kamakura, M., Ikushiro, S., Yasukawa, K., Shiro, Y., Sakaki, T. "Production of an active form of vitamin D2 by genetically engineered CYP105A1". Biochem. Biophys. Res. Commun. , 486, 336-341 (2017) [PubMed]
- 杉本宏 "バクテリアにおけるヘムの獲得と輸送の構造生物学". 日本結晶学会誌 59, 166-173 (2017)
- 杉本宏 "ヘム輸送タンパク質の立体構造". 感染・炎症・免疫 47, 41-44 (2017)
[2016]
- Naoe, Y., Nakamura, N., Doi, A., Sawabe, M., Nakamura, H., Shiro, Y., and Sugimoto, H. "Crystal structure of bacterial haem importer complex in the inward-facing conformation. Nature Commun. 13411 (2016). [doi]
- Shoji, O., Fujishiroa, T., Nishioa, K., Kanoa, Y., Kimotoa, H., Chiena, S. C., Onodaa, H., Muramatsua, A., Tanakaa, S., Horia, A., Sugimoto, H., Shiro, Y., Watanabe, Y. "A substrate-binding-state mimic of H2O2-dependent cytochrome P450 produced by one-point mutagenesis and peroxygenation of non-native substrates". Catal. Sci. Technol. 6, 5806-5811(2016) [doi]
- Sakaguchi, M., Kimura, T., Nishida, T., Tosha, T., Sugimoto, H., Yamaguchi, Y., Yanagisawa, S., Ueno, G., Murakami, H., Ago, H., Yamamoto, M., Ogura, T., Shiro, Y., Kubo, M. "A nearly on-axis spectroscopic system for simultaneously measuring UV-visible absorption and X-ray diffraction in the SPring-8 structural genomics beamline". J. Synchrotron Rad. 23, 334-338 (2016) [PubMed]
[2015]
- Doi, A., Nakamura, H., Shiro, Y., Sugimoto, H. "Structure of the response regulator ChrA in the haem-sensing two-component system of Corynebacterium diphtheriae". Acta Crystallogr. F Struct. Biol. Commun. 71, 966-971 (2015) [PubMed]
- Cong, Z., Shoji, O., Kasai, C., Kawakami, N., Sugimoto, H., Shiro, Y. & Watanabe, Y. "Activation of wild-type cytochrome P450BM3 by the next generation of decoy molecules: enhanced hydroxylation of gaseous alkanes and crystallographic evidence." ACS Catal. 5, 150-156 (2015) [doi]
[2014]
- Takagi, K., Al-Amin, M., Hoshiya, N., Wouters, J., Sugimoto, H., Shiro, Y., Fukuda, H., Shuto, S., Arisawa, M. "Palladium-nanoparticle-catalyzed 1,7-palladium migration involving C-H activation, followed by intramolecular amination: regioselective synthesis of N1-arylbenzotriazoles and an evaluation of their inhibitory activity toward indoleamine 2,3-dioxygenase". J. Org. Chem. 79, 6366-6371 (2014)
- Sato, N., Ishii, S., Sugimoto, H., Hino, T., Fukumori, Y., Sako, Y., Shiro, Y., Tosha, T. "Structures of reduced and ligand-bound nitric oxide reductase provide insights into functional differences in respiratory enzymes". Proteins 82, 1258-1271 (2014)
- Shirataki, C., Shoji, O., Terada, M., Ozaki, S., Sugimoto, H., Shiro, Y. & Watanabe, Y. "Inhibition of Heme uptake in Pseudomonas aeruginosa by its hemophore (HasAp) bound to synthetic metal complexes." ""Angew. Chem. Int. Ed. 53, 2862-2866 (2014) [PubMed]
- Okamoto, Y., Onoda, A., Sugimoto, H., Takano, Y., Hirota, S., Kurtz, D. M., Jr., Shiro, Y. & Hayashi, T. "H2O2-dependent substrate oxidation by an engineered diiron site in a bacterial hemerythrin." Chem. Commun. (Camb) 50, 3421-3423 (2014) [doi]
- Hirata, K., Shinzawa-Itoh, K., Yano, N., Takemura, S., Kato, K., Hatanaka, M., Muramoto, K., Kawahara, T., Tsukihara, T., Yamashita, E., Tono, K., Ueno, G., Hikima, T., Murakami, H., Inubushi, Y., Yabashi, M., Ishikawa, T., Yamamoto, M., Ogura, T., Sugimoto, H., Shen, J. R., Yoshikawa, S. & Ago, H. "Determination of damage-free crystal structure of an X-ray-sensitive protein using an XFEL." Nature Methods 11, 734-736 (2014) [PubMed]
[~2013]
- Okamoto, Y., Onoda, A., Sugimoto, H., Takano, Y., Hirota, S., Kurtz, D. M., Jr., Shiro, Y. & Hayashi, T. "Crystal Structure, Exogenous Ligand Binding, and Redox Properties of an Engineered Diiron Active Site in a Bacterial Hemerythrin." Inorg. Chem. 52, 13014–13020 (2013) [PubMed]
- Yanagisawa, S., Hara, M., Sugimoto, H., Shiro, Y. & Ogura, T. "Resonance Raman study on indoleamine 2,3-dioxygenase: Control of reactivity by substrate-binding." Chem. Phys. 419, 178 (2013) [doi]
- Fujishiro, T., Shoji, O., Kawakami, N., Watanabe, T., Sugimoto, H., Shiro, Y., Watanabe, Y. "Chiral Substrate Analogues Assisted Stereoselective Epoxidation Catalyzed by H2O2-Dependent Cytochrome P450SPa." Chem. Asian J. 7, 2286 (2012) [PubMed]
- Sawai, H., Yamanaka, M., Sugimoto, H., Shiro, Y. & Aono, S. "Structural basis for the transcriptional regulation of heme homeostasis in Lactococcus lactis." J. Biol. Chem. 287, 30755 (2012)) [PubMed]
- Sugimoto, H., Shiro, Y. "Diversity and substrate specificity in the structures of steroidogenic cytochrome P450 enzymes". Biol. Pharm. Bull. 35, 818-823 (2012) [PubMed]
- Kondo, H., Hanada, Y., Sugimoto, H., Hoshino, T., Garnham, C. P., Davies, P. L., Tsuda, S. "Ice-binding site of snow mold fungus antifreeze protein deviates from structural regularity and high conservation." Proc. Natl. Acad. Sci. U.S.A. 109, 9360-9365 (2012) [PubMed]
- Sawai, H., Sugimoto, H., Shiro, Y., Ishikawa, H., Mizutani, Y., Aono, S. "Structural basis for oxygen sensing and signal transduction of the heme-based sensor protein Aer2 from Pseudomonas aeruginosa". Chem Commun (Camb) 48, 6523-6525 (2012) [PubMed]
- Matsumoto, Y., Tosha, T., Pisliakov, A. V., Hino, T., Sugimoto, H., Nagano, S., Sugita, Y., Shiro, Y. "Crystal structure of quinol-dependent nitric oxide reductase from Geobacillus stearothermophilus ". Nature Struct. Mol. Biol. 19, 238-245 (2012). [PubMed]
- Shiro, Y., Sugimoto, H., Tosha, T., Nagano, S., Hino, T. "Structural basis for nitrous oxide generation by bacterial nitric oxide reductases". Phil. Trans. R. Soc. B 367, 1195-1203 (2012) [PubMed]
- Hino, T., Nagano, S., Sugimoto, H., Tosha, T., Shiro, Y. "Molecular structures and mechanism of bacterial nitric oxide reductase". Biochim. Biophys. Acta 1817, 680–687 (2011) [PubMed]
- Fujishiro, T., Shoji, O., Nagano, S., Sugimoto, H., Shiro, Y., Watanabe, Y. "Crystal structure of H2O2-dependent cytochrome P450SPα with its bound fatty acid substrate: insight into the regioselective hydroxylation of fatty acids at the α position". J. Biol. Chem. 286, 29941-29950 (2011) [PubMed]
- Onoda, A., Okamoto, Y., Sugimoto, H., Shiro, Y., Hayashi, T. "Crystal structure and spectroscopic studies of a stable mixed-valent state of the hemerythrin-like domain of a bacterial chemotaxis protein". Inorg. Chem. 50, 4892-4899 (2011) [PubMed]
- Makino, M., Sawai, H., Shiro, Y., Sugimoto, H. "Crystal structure of the carbon monoxide complex of human cytoglobin". Proteins 79, 1143-1153 (2011) [PubMed]
- Yanagisawa, S., Horitani, M., Sugimoto, H., Shiro, Y., Okada, N., Ogura, T. "Resonance Raman study on the oxygenated and the ferryl-oxo species of indoleamine 2,3-dioxygenase during catalytic turnover". Faraday Discus. 148, 239-247 (2011) [PubMed]
- Sakaki, T., Sugimoto, H., Hayashi, K., Yasuda, K., Munetsuna, E., Kamakura, M., Ikushiro, S., Shiro, Y. "Bioconversion of vitamin D to its active form by bacterial or mammalian cytochrome P450". Biochim. Biophys. Acta 1814, 249-256 (2011) [PubMed]
- Hino, T., Matsumoto, Y., Nagano, S., Sugimoto, H., Fukumori, Y., Murata, T., Iwata, S., Shiro, Y. "Structural basis of biological N2O generation by bacterial nitric oxide reductase". Science 330, 1666-1670 (2010) [PubMed]
- Yanagisawa, S., Sugimoto, H., Shiro, Y., Ogura, T. "A specific interaction of L-tryptophan with CO of CO-bound indoleamine 2,3-dioxygenase identified by resonance Raman spectroscopy". Biochemistry 49, 10081-10088 (2010) [PubMed]
- Hayashi, K., Yasuda, K., Sugimoto, H. et al "Three-step hydroxylation of vitamin D3 by a genetically engineered CYP105A1: enzymes and catalysis". FEBS J. 277, 3999-4009 (2010) [PubMed]
- Chung, L. W., Li, X., Sugimoto, H., Shiro, Y., Morokuma, K. "ONIOM study on a missing piece in our understanding of heme chemistry: bacterial tryptophan 2,3-dioxygenase with dual oxidants". J. Am. Chem. Soc. 132, 11993-12005 (2010) [PubMed]
- Nakashima, H., Ikkyu, K., Nakashima, K. et al "Design of novel hypoxia-targeting IDO hybrid inhibitors conjugated with an unsubstituted L-Trp as an IDO affinity moiety". Adv. Exp. Med. Biol. 662, 415-421 (2010) [PubMed]
- Yanagisawa, S., Yotsuya, K., Hashiwaki, Y., Horitani, M., Sugimoto, H., Shiro, Y., Appelman, E. H., Ogura, T. "Identification of the Fe-O2 and the Fe=O heme species for indoleamine 2,3-dioxygenase during catalytic turnover". Chem. Lett. 39, 36-37 (2009) [PubMed]
- Yamada, S., Sugimoto, H., Kobayashi, M., Ohno, A., Nakamura, H., Shiro, Y. "Structure of PAS-linked histidine kinase and the response regulator complex". Structure 17, 1333-1344 (2009) [PubMed]
- Sawai, H., Sugimoto, H., Kato, Y., Asano, Y., Shiro, Y., Aono, S. "X-ray crystal structure of the Michaelis complex of aldoxime dehydratase". J. Biol. Chem. 284, 32089-32096 (2009) [PubMed]
- Yaoi, K., Kondo, H., Hiyoshi, A., Noro, N., Sugimoto, H., Tsuda, S., Miyazaki, K. "The crystal structure of a xyloglucan-specific endo-beta-1,4-glucanase from Geotrichum sp. M128 xyloglucanase reveals a key amino acid residue for substrate specificity". FEBS J. 276, 5094-5100 (2009) [PubMed]
- Fukumura, E., Sugimoto, H., Misumi, Y., Ogura, T., Shiro, Y. "Cooperative binding of L-trp to human tryptophan 2,3-dioxygenase: resonance Raman spectroscopic analysis". J. Biochem. (Tokyo) 145, 505-515 (2009) [PubMed]
- Hayashi, K., Sugimoto, H., Shinkyo, R. et al "Structure-based design of a highly active vitamin D hydroxylase from Streptomyces griseolus CYP105A1". Biochemistry 47, 11964-11972 (2008)
- Chung, L. W., Li, X., Sugimoto, H., Shiro, Y., Morokuma, K. "Density functional theory study on a missing piece in understanding of heme chemistry: the reaction mechanism for indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase". J. Am. Chem. Soc. 130, 12299-12309 (2008)
- Nakashima, H., Uto, Y., Nakata, E. et al "Synthesis and biological activity of 1-methyl-tryptophan-tirapazamine hybrids as hypoxia-targeting indoleamine 2,3-dioxygenase inhibitors". Bioorg. Med. Chem. 16, 8661-8669 (2008)
- Nishimiya, Y., Kondo, H., Takamichi, M., Sugimoto, H., Suzuki, M., Miura, A., Tsuda, S. "Crystal structure and mutational analysis of Ca2+-independent type II antifreeze protein from longsnout poacher, Brachyopsis rostratus". J. Mol. Biol. 382, 734-746 (2008)
- Sugimoto, H., Shinkyo, R., Hayashi, K. et al "Crystal structure of CYP105A1 (P450SU-1) in complex with 1alpha,25-dihydroxyvitamin D3". Biochemistry 47, 4017-4027 (2008)
- Harada, K., Makino, M., Sugimoto, H., Hirota, S., Matsuo, T., Shiro, Y., Hisaeda, Y., Hayashi, T. "Structure and ligand binding properties of myoglobins reconstituted with monodepropionated heme: functional role of each heme propionate side chain". Biochemistry 46, 9406-9416 (2007)
- Makino, M., Sugimoto, H., Shiro, Y., Asamizu, S., Onaka, H., Nagano, S. "Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton". Proc. Natl. Acad. Sci. U.S.A. 104, 11591-11596 (2007)
- Yaoi, K., Kondo, H., Hiyoshi, A., Noro, N., Sugimoto, H., Tsuda, S., Mitsuishi, Y., Miyazaki, K. "The structural basis for the exo-mode of action in GH74 oligoxyloglucan reducing end-specific cellobiohydrolase". J. Mol. Biol. 370, 53-62 (2007)
- Hayashi, T., Murata, D., Makino, M., Sugimoto, H., Matsuo, T., Sato, H., Shiro, Y., Hisaeda, Y. "Crystal structure and peroxidase activity of myoglobin reconstituted with iron porphycene". Inorg. Chem. 45, 10530-10536 (2006)
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[著書]
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