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メンバー

Postdoctoral Researcher

Hisham Dokainish

EDUCATION
2014
Ph. D. (Chemistry and Biochemistry) University of Windsor, Canada
2010
M. Sc. (Chemistry) University of New Brunswick, Canada
2004
B. Phm. (Pharmacy) Helwan University, Egypt
RESEARCH EXPERIENCES
2018.4 - present
Postdoctoral Researcher, RIKEN Theoretical Molecular Science Laboratory, Japan
2017.7 - 2018.3
Postdoctoral Researcher, Tokyo Institute of Technology, Japan
2014.12 - 2017.6
Postdoctoral Researcher, University of Tokyo, Japan
AWARDS AND FELLOWSHIPS/SCHOLARSHIPS
2014
Mitacs Elevate Postdoctoral Fellowship, Canada.
2014
NVIDIA Rising Star Award at the Canadian Society of Chemistry Conference for best presentation, Vancouver, Canada.
2010-2014
Tuition Scholarship, University of Windsor, Canada.
2010-2012
International Doctoral Excellence Scholarship, University of Windsor, Canada.
PROFESSIONAL AFFILIATIONS
Canadian Society of Chemistry, Japan Biophysical Society
RESEARCH PROJECTS
  1. Protein Crowding in Cellular Environment
PUBLICATIONS

Peer review articles
  1. Electron Fate and Mutational Robustness in the Mechanism of (6-4) Photolyase-Mediated DNA Repair.

    H. M. Dokainish, D. Yamada, T. Iwata, H. Kandori, A. Kitao*
    ACS. Catal., 7, 4835-4845 (2017).

  2. A Pseudohypervalent Sulfur Intermediate as an Oxidative Protective Mechanism in the Archaea Peroxiredoxin Enzyme ApTPx.

    H. M. Dokainish, D. J. Simard, J. W. Gauld*
    J. Phys. Chem. B, 121, 6570-6579 (2017).

  3. Computational Assignment of the Histidine Protonation State in (6-4) Photolyase Enzyme and Its Effect on the Protonation Step.

    H. M. Dokainish, A. Kitao*
    ACS. Catal., 6, 5500-5507 (2016).

  4. Functional Conversion of CPD and (6–4) Photolyases by Mutation.

    D. Yamada, H. M. Dokainish, T. Iwata, J. Yamamoto, T. Ishikawa, T. Todo, S. Iwai, E. D. Getzoff, A. Kitao, H. Kandori*
    Biochemistry, 55, 4173-4183 (2016).

  5. Formation of a Stable Iminol Intermediate in the Redox Regulation Mechanism of Protein Tyrosine Phosphatase 1B (PTP1B).

    H. M. Dokainish, J. W. Gauld*
    ACS. Catal., 5, 2195-2202 (2015).

  6. Computational investigations on the catalytic mechanism of maleate isomerase: the role of the active site cysteine residues.

    H. M. Dokainish, B. F. Ion, J. W. Gauld*
    Phys. Chem. Chem. Phys., 16, 12462-12474 (2014).

  7. A Molecular Dynamics and Quantum Mechanics/Molecular Mechanics Study of the Catalytic Reductase Mechanism of Methionine Sulfoxide Reductase A: Formation and Reduction of a Sulfenic Acid.

    H. M. Dokainish, J. W. Gauld*
    Biochemistry, 52, 1814-1827 (2013).

  8. Reply to the “Comment on 'A Sulfonium Cation Intermediate in the Mechanism of Methionine Sulfoxide Reductase B: A DFT Study’”

    J. J. Robinet, H. M. Dokainish, D. J. Paterson, J. W. Gauld*
    J. Phys. Chem. B, 115, 10776-10777 (2011).

  9. A Sulfonium Cation Intermediate in the Mechanism of Methionine Sulfoxide Reductase B: A DFT Study.

    J. J. Robinet, H. M. Dokainish, D. J. Paterson, J. W. Gauld*
    J. Phys. Chem. B, 115, 9202-9212 (2011).

  10. Assignment of the 6,6′-Dioxo-3,3′-biverdazyl Ground State by Using Broken Symmetry and Spectroscopy Oriented Configuration Interaction Techniques.

    S. M. Mattar*, H. M. Dokainish
    J. Phys. Chem. A, 114, 2010-2021 (2010).


Review article
  1. Multi-Scale Computational Enzymology: Enhancing Our Understanding of Enzymatic Catalysis.

    R. Gherib, H. M. Dokainish, J. W. Gauld*
    Int. J. Mol. Sci., 15, 401-422 (2014).

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