私たちのチームでは酵母遺伝学を用いて化合物（分子リガンド）の標的／作用機序を解明する方法を開発しています

Small molecular ligands with unique activities must have the specific target molecules that exist in their cells or organisms. Identification of the target molecules is critical for elucidating the mode of action of the molecular ligands and for drug development. However, drug target identification has been difficult in general, because the mode of interactions between the molecular ligands and their targets is not uniform. Our team aims at developing innovative techniques based on global analysis of yeast genetic interaction, which leads to quick and accurate detection of the ligand-target interactions.