Original Articles
2013
Bhat HB, Kishimoto T, Abe M, Makino A, Inaba T, Murate M, Dohmae N, Kurahashi A, Nishibori K, Fujimori F, Greimel P, Ishitsuka R, Kobayashi T.:
"Binding of a pleurotolysin ortholog from Pleurotus eryngii to sphingomyelin and cholesterol-rich membrane domains."
J Lipid Res 54, 2933-2943. (2013)

Yilmaz N, Yamada T, Greimel P, Uchihashi T, Ando T, Kobayashi T.:
"Real time visualization of assembling of a sphingomyelin-specific toxin on planar lipid membranes."
Biophys J 105, 1397-1405. (2013)

Kumagai A, Ando R, Miyatake H, Greimel P, Kobayashi T, Hirabayashi Y, Shimogori T, Miyawaki A.:
"A bilirubin-inducible fluorescent protein from eel muscle."
Cell 153, 1602-1611. (2013)

Ueda Y, Makino A, Murase-Tamada K, Sakai S, Inaba T, Hullin-Matsuda F, Kobayashi T.:
"Sphingomyelin regulates the transbilayer movement of diacylglycerol in the plasma membrane of Madin-Darby canine kidney cells."
FASEB J 27, 3284-3297. (2013)

Kato U, Inadome H, Yamamoto M, Emoto K, Kobayashi T, Umeda M.:
"Role for phospholipid flippase complex of ATP8A1 and CDC50A proteins in cell migration."
J Biol Chem 288: 4922-4934. (2013)

2012
Hullin-Matsuda F, Tomishige N, Sakai S, Ishitsuka R, Ishii K, Makino A, Greimel P, Abe M, Laviad EL, Lagarde M, Vidal H, Saito T, Osada H, Hanada K, Futerman AH, Kobayashi T.:
"Limonoid compounds inhibit sphingomyelin biosynthesis by preventing CERT protein-dependent extraction of ceramides from the endoplasmic reticulum."
J Biol Chem 287, 24397-24411. (2012)

Ikenouchi J, Suzuki M, Umeda K, Ikeda K, Taguchi R, Kobayashi Te, Sato SB, Kobayashi To, Stols DB, Umeda M.
Lipid polarity is maintained in the absence of tight junctions.
J. Biol. Chem. 287(12), 9525-33. (2012)

Abe M, Makino A, Hullin-Matusda F, Kamijo K, Ohno-Iwashita Y, Hanada K, Mizuno H, Miyawaki A, Kobayashi T.
A role for sphingomyelin-rich lipid domains in the accumulation of PIP2 to the cleavage furrow during cytokinesis.
Mol. Cell Biol. 32, 1396-1407. (2012)

Ogushi F, Ishitsuka R, Kobayashi T, Sugita Y.
Rapid flip-frop motions of diacylglycerol and ceramide in phospholipid bilayers.
Chemi. Phys. Lett. 522, 96-102. (2012)

Wang T, Shogomori H, Hara M, Yamada T and Kobayashi T.
Nanomechanical Recognition of Sphingomyelin-Rich Membrane Domains by Atomic Force Microscopy,
Biochemistry 51, 74-82. (2012)

Tan H-H, Makino A, Sudesh K, Greimel P and Kobayashi T.
Spectroscopic Evidence for the Unusual Stereochemical Configuration of an Endosome-Specific Lipid,
Angew Chem. 51, 533-535. (2012)

Sarker SR, Arai S, Murate M, Takahashi H, Takata M, Kobayashi T, Takeoka S.
Evaliation of the influence of ionization states and spacers in the thermotropic phase behaviour of amino acid-based cationic lipids and the transfection efficiency of their assemblies.
Int. J. Pharm. 422, 364-73. (2012)

Takahashi H, Hayakawa T, Murate M, Greimel P, Nagatsukad Y, Kobayashi T, Hirabayashi Y.
Phosphatidylglucoside: Its structure, thermal behavior, and domain formation in plasma membranes,
Chemistry and Physics of Lipids 165, 197-206. (2012)

2011
Ishitsuka R, Saito T, Osada H, Ohno-Iwashita Y, Kobayashi T.(2011) Fluorescence image screening for chemical compounds modifying cholesterol metabolism and distribution, J. Lipid Res. 52, 2084-2094.

Ayala Pena VB, Bonini IC, Antollini SA, Kobayashi T and Banantes FJ. (2011)a7-Type Acetylcholine Receptor Localization and its Modulation by Nicotine and Cholesterol in Vascular Endothelial Cells, J. Cellular Biochemistry 112, 3276-3288.

Abdel Shakor AB, Taniguchi M, Kitatani K, Hashimoto M, Asano S, Hayashi A, Nomura K, Bielawski J, Bielawska A, Watanabe K, Kobayashi T, Igarashi Y, Umehara H, Takeya H, Okazaki T. (2011)SMS1-generated sphingomyelin plays an inportant role in transferrin trafficking and cell proliferation. J. Biol. Chem. 286, 36053-62

Mizuno H, Abe M, Dedecker P, Makino A, Rocha S, Ohno-Iwashita Y, Hofkens J, Kobayashi T, Miyawaki A. (2011) Fluorescent probes for superresolution imaging of lipid domains on the plasma membrane. Chem. Sci. 2, 1548-1553.

Nabetani T, Makino A, Hullin-Matsuda F, Hirakawa T, Takeoka S, Okino N, Ito M, Kobayashi T, Hirabayashi Y.(2011) Multiplex analysis of sphingolipids using amine-reactive tags(iTRAQ) J, Lipid Res. 52, 1294-302.

Kohyama A, Nabetani T, Miura M, Hirabayashi Y.(2011) Glucosylceramide synthase in the fat body controls energy metabolism in Drosophila. Journal of Lipid Research 52(7), 1392-1399.

Kina K, Matsuda H, Nakayama H, Nagatsuka Y, Nabetani T, Hirabayashi Y, Takahashi Y, Shimada K, Daida H, Ogawa H, Takamori K, Iwabuchi K. (2011) The Novel Neutrophil Differentiation Marker Phosphatidylglucoside Mediates Neutrophil Apotosis. The Journal of Immunology 186(9) 5232-5332.

2010
Murate M, Hayakawa T, Ishii K, Inadome H, Greimel P, Watanabe M, Nagatsuka Y, Ito K, Ito Y, Takahashi H, Hirabayashi Y, Kobayashi T.(2010)Phosphatidylglucoside forms specific lipid domains on the outer leaflet of the plasma membrane. Biochemistry 49(23), 4732-4739.

Rezeznicka I, Sovago M, Backus E, Bonn M, Yamada T, Kobayashi T, Kawai M.(2010) Duramycin-Induced destabilization of a phosphatidylethanolamine monolayer at the air-water interface observed by vibrational sum-frequency generation spectroscopy, Langmuir 26(20), 16055-16062.

Takahashi H, Hayakawa T, Ito K, Takata M, Kobayashi T.(2010) Small-angle X-ray scattering study on the bilayer structure of synthetic and bovine heart cardiolipins. Journal of Physics: Conference Series 247(1), 12021-1-12021-8.

Aoki T, Hirano M, Takeuchi Y, Kobayashi T, Yanagida T, Ide T.(2010) Single channel properties of lysenin measured in artifical lipid bilayers and their applications to biomolecule detection. Proceedings of the Japan Academy Series B 86(9), 920-925.

Nishimura S, Arita Y, Honda M, Iwamoto K, Matsuyama A, Shirai A, Kakeya H, Kobayashi T, Matsunaga S, Yoshida M (2010) Marine antifungal theonellamides target 3β-hydroxysterol to activate Rho1 signaling, Nature Chemical Biology, 6, 519-526.

2009
Singh R, Marks D, Holicky E, Wheatly C, Kaptzan T, Sato S, Kobayashi T, Ling K, Pagano R.(2009) Gangliosides and veta1-integrin are required for caveolae and membrane domains. Traffic, 2896.

Tamura K, Makino A, Hullin-Matsuda F, Kobayashi T, Furihata M, Chung S, Ashida S, Miki T, Fujioka T, Shuin T, Nakamura Y and Nakagawa H. (2009) Lipogenic Enzyme ELOVL7 Promotes Prostate Cancer Growth through Saturated Long-Chain Fatty-acid Metabolism. Cancer Res. 69, 8133-8140.

Mukai A, Kurisaki T, Sato SB, Kobayashi T, Kondoh G, Hashimoto N.(2009) Dynamic clustering and dispersion of lipid rafts contribute to fusion competence of myogenic cells. Experimental Cell Research. 315, 3052-3063.

Matsunaga S, Matsunaga T, Iwamoto K, Yamada T, Shibayama M, Kawai M, Kobayashi T. (2009) Visualization of Phospholipid Particle Fusion Induced by Duramycin. Langmuir 25, 8200-8207.

Baba A, Akagi K, Takayanagi M, Flanagan JG, Kobayashi T, Hattori M. (2009) Fyn tyrosine kinase regulates the surface expression of GPI-linked ephrin via the modulation of sphingomyelin metabolism. J. Biol. Chem. 284, 9206-9214.

Sugawara K, Tajima Y, Kawashima I, Tsukimura T, Saito S, Ohno K, Iwamoto K, Kobayashi T, Itoh K, Sakuraba H. (2009) Molecular interaction of imino sugars with human alpha-galactosidase Insight into the mechanism of complex formation and pharmacological chaperone action in Fabry disease. Mol. Genet. Metab. 96, 233-238

Bouvier J, Zemski Berry KA, Hullin-Matsuda F, Makino A, Michaud S, Geloen A, Murphy RC, Kobayashi T, Lagarde M, Delton-Vandenbroucke I. (2009) Selective decrease of bis(monoacylglycero)phosphate content in macrophages by high supplementation with docosahexaenoic acid. J. Lipid Res. 50, 243-255

Ichikawa N, Iwabuchi K, Kurihara H, Ishii K, Kobayashi T, Sasaki T, Hattori N, Mizuno Y, Hozumi K, Yamada Y, Arikawa-Hirasawa E. (2009) Binding of laminin-1 to GM1 ganglioside in lipid rafts is critical for neurite outgrowth. J. Cell Sci. 122, 289-299

Ishitsuka R, Hirabayashi Y, Kobayashi T. (2009) Glycosphingolipid deficiency increases the sterol regulatory element-mediated gene transcription. Biochem. Biophus. Res. Comm. 378, 240-243

2008
Ide T, Kobayashi T, Hirano M.(2008) Lipid Bilayers at the Gel Interface for Single Ion Channel Recordings. Anal. Chem. 80, 7792-7795

Yoshimizu M, Tajima Y, Matsuzawa F, Aikawa SI, Iwamoto K, Kobayashi T, Edmunds T, Fujishima K, Tsuji D, Itoh K, Ikekika M, Kawashima I, Sugawara K, Ohyanagi N, Suzuki T, Togawa T, Ohno K, Sakuraba H. (2008) Clin. Chim. Acta in press.

Iwabuchi K, Prinetti A, Sonnino S, Mauri L, Kobayashi T, Ishii K, Kaga N, Murayama K, Kurihara H, Nakayama H, Yoshizaki F, Takamori K, Ogawa H, Nagaoka I. (2008) Involvement of very long fatty acid-containing lactosylceramide in lactosylceramide-mediated superoxide generation and migration in neutrophils. Glycoconj J 25, 357-374.

Hirano M, Kobayashi T, Ide T.(2008)Lipid Bilayers at Gel/Gel Interface for Ion Channel Recordings, e-J. Surf. Sci. Nanotechnol. 6, 130-133.

2007
Matsunaga S, Yokomori R, Ino D, Yamada T, Kawai M, Kobayashi T. (2007)　 EC-STM observation on electrochemical response of fluidic phospholipid monolayer on Au(111) modified with 1-octanethiol. Electrochem. Commun. 9, 645-650.

Hayakawa T, Makino A, Murate M, Sugimoto I, Hashimoto Y, Takahashi H, Ito K, Fujisawa T, Matsuo H, Kobayashi T. (2007)　pH-dependent formation of membranous cytoplasmic body-like structure of ganglioside GM1/bis(monoacylglycero)phosphate mixed membranes. Biophys. J. 92, L13-16.

Koseki M, Hirano KI, Masuda D, Ikegami C, Tanaka M, Ota A, Sandoval JC, Nakagawa-Toyama Y, Sato SB, Kobayashi T, Shimada Y, Ohno-Iwashita Y, Matsuura F, Shimomura I, Yamashita S. (2007) Increased lipid rafts and accelerated lipopolysaccharide-induced tumor necrosis factor alpha secretion in Abca1-deficient macrophages. J. Lipid Res. 48, 299-306.

Delton-Vandenbroucke I, Bouvier J, Makino A, Besson N, Pageaux J-F, Lagarde M, Kobayashi T. (2007) Anti-bis(monoacylglycero)phosphate antibody induces the accumulation of acetylated-low density lipoprotein-derived cholesterol in cultured macrophages. J. Lipid Res. 48, 543-552.

Ishitsuka R, Kobayashi T. (2007) Cholesterol and lipid/protein ratio control the oligomerization of a sphingomyelin-specific toxin, lysenin. Biochemistry 46, 1495-1502.

Kurumada S, Onishi A, Imai H, Ishii K, Kobayashi T, Sato SB. (2007) 　Stage specific association of apolipoprotein A-I and E in developing mouse retina. Invest. Opht. Vis.Sci. 48, 1815-1823.

Takahashi H, Hayakawa T, Kawasaki Y, Ito K, Fujisawa T, Kodama M, Kobayashi T. (2007) Structural characterization of N-lignoceroyl (C24:0) sphingomyelin bilayer membranes : A reevaluation. J.Appl.Cryst. 40, s312-s317.

Takahashi M, Murate M, Fukuda M, Sato SB, Ohta A, Kobayashi T. (2007) Cholesterol controls lipid endocytosis through Rab11. Mol. Biol. Cell 18, 2667-2677.

Iwamoto K, Hayakawa T, Murate M, Makino A, Ito K, Fujisawa T, Kobayashi T. (2007) Curvature-dependent recognition of ethanolamine phospholipids by duramycin and cinnamycin. Biophys. J. 93, 1608-1619.

Hayakawa T, Makino A, Michaud S., Lagarde M., Douteau A., Ito K., Hirai M., Kobayashi T. (2007) Membrane properties of dipalmitoyl bis(monoaclyglycero)phosphate. Membrane 32, 221-228.

Hullin-Matsuda F, Kawasaki K, Delton-Vandenbroucke I, Xu Y, Nishijima M, Lagarde M, Schlame M, Kobayashi T. (2007) De novo biosynthesis of the late endosome lipid, bis(monoacyl- glycero)phosphate. J. Lipid Res. 48, 1997-2008.

2006
Makino A, Ishii K, Murate M, Hayakawa T, Suzuki Y, Suzuki M, Ito K, Fujisawa T, Matsuo H, Ishitsuka R, Kobayashi T. (2006) D-threo-1-phenyl-2-decanoylamino-3-morpholino-1- propanol alters cellular cholesterol homeostasis by modulating the endosome lipid domains. Biochemistry, 45, 4530-41.

Besson N, Hullin-Matsuda F, Makino A, Murate M, Lagarde M, Pageaux J-F, Kobayashi T, Dalton-Vandenbroucke I. (2006) Selective incorporation of docosahexaenoic acid to lysobisphosphatidic acid in cultured THP-1 macrophages. Lipids. 41, 189-196.

Hayakawa T, Hirano Y, Makino A, Michaud S, Lagarde M, Pageaux J-F, Doutheau A, Ito K, Fujisawa T, Takahashi H, Kobayashi T. (2006) Differential membrane packing of stereoisomers of bis(monoacylglycero)phosphate. Biochemistry 45, 9198-9209.

Singh RD, Liu Y, Wheatley CL, Holicky EL, Makino A, Marks DL, Kobayashi T, Subramaniam G, Bittman R, Pagano RE. (2006) 　Caveolar endocytosis and microdomain association of a glycolipid analog is dependent on its sphingosine stereochemistry. J. Biol. Chem. 281, 30660-30668.

Sakuraba H, Chiba Y, Kotani M, Kawashima I, Ohsawa M, Tajima Y, Takaoka Y, Jigami Y, Takahashi H, Hirai Y, Shimada T, Hashimoto Y, Ishii K, Kobayashi T, Wataba K, Fukushige T, Kanzaki T. (2006) Corrective effect of yeast recombinant human α-galactosidase having N-linked sugar chains suitable for lysosomal delivery on Fabry mice. J. Hum. Gen. 51, 341-52.

2005
Yamaji-Hasegawa A, Takahashi A, Tetsuka Y, Senoh Y, Kobayashi T. (2005) Fungal metabolite sulfamisterin suppresses sphingolipid synthesis through inhibition of serine palmitoyltransferase. Biochemistry 44, 268-277.

Ichimaru N, Murai M, Abe M, Hamada T, Makino S, Nishioka T, Makabe H, Makino A, Kobayashi T, Miyoshi H. (2005) Inhibition Mechanism of Dlac-Acetogenins: A Novel Type of Inhibitors of Bovine Heart Mitochondrial Complex I. Biochemistry 44, 816-25.

Yorikawa C, Shibata H, Waguri S, Hatta K, Horii M, Katoh K, Kobayashi T, Uchiyama Y, Maki M. (2005) Human CHMP6, a myristoylated ESCRT-III protein, interacts directly with an ESCRT-II component EAP20 and regulates endosomal cargo sorting. Biochem. J. 387, 17-26.

Sato H, Maeba T, Yanase R, Yamaji-Hasegawa A, Kobayashi T, Chida N. (2005) Total synthesis and biological activities of (+)-sulfamisterin (AB5366) and its analogues. J. Antibiot. 58, 37-49.

Kiyokawa E, Baba T, Otsuka N, Makino A, Ohno S, Kobayashi T. (2005) Spatial and functional heterogeneity of sphingolipid-rich membrane domains. J. Biol. Chem. 280, 24072-24084.

Miyaji M, Zhe-Xiong J, Yamaoka S, Amakawa R, Fukuhara S, Sato SB, Kobayashi T, Domae N, Mimori T, Bloom ET, Okazaki T, Umehara H.(2005) Role of membrane sphingomyelin and ceramide in platform formation for Fas-mediated apoptosis. J. Exp. Med. 202, 249-59.

2004
Ishitsuka R, Yamaji-Hasegawa A, Makino A, Hirabayashi Y, Kobayashi T. (2004) A lipid-specific toxin reveals heterogeneity of sphingomyelin-containing membranes. Biophys. J. 86, 296-307.

Sato S, Ishii K, Makino A, Iwabuchi K, Yamaji-Hasegawa A, Senoh Y, Nagaoka I, Sakuraba H, Kobayashi T. (2004) Distribution and transport of cholesterol-rich membrane domains monitored by a membrane-impermeant fluorescent polyethylene glycol-derivatized cholesterol. J.Biol.Chem. 279, 23790-23796.

Kiyokawa E, Makino A, Ishii K, Otsuka N, Yamaji-Hasegawa A, Kobayashi T. (2004) Recognition of sphingomyelin by lysenin and lysenin-related proteins. Biochemistry 43, 9766-9773.

Iwamoto K, Kobayashi S, Fukuda R, Umeda M, Kobayashi T, Ohta A. (2004) Local exposure of phosphatidylethanolamine on the yeast plasma membrane is implicated in cell polarity. Genes Cells 9, 891-903.

Ishiwari K, Kotani M, Suzuki M, Pumbo E, Suzuki A, Kobayashi T, Ueno T, Fukushige T, Kanzaki T, Imada M, Itoh K, Tajima Y, Sakuraba H. (2004) Biochemical and cytochemical studies on a Japanese Salla disease case associated with renal disorder. J. Hum. Gen. 49, 656-563.

Laulagnier K, Motta C, Hamdi S, Roy S, Fauvelle F, Pageaux JF, Kobayashi T, Salles JP, Perret B, Bonnerot C, Record M. (2004) Mast cell- and dendritic cell-derived exosomes display a specific lipid composition and an unusual membrane organization. Biochem. J. 380, 161-71.

2003
Makino A, Baba T, Fujimoto K, Iwamoto K, Yano Y, Terada N, Ohno S, Sato SB, Ohta A, Umeda M, Matsuzaki K, Kobayashi T. (2003) Cinnamycin (Ro09-0198) promotes cell binding and toxicity by inducing transbilayer lipid movement. J. Biol. Chem. 278, 3204-3209.

Yamaji-Hasegawa A, Makino A, Baba T, Senoh Y, Kimura-Suda H, Sato B S, Terada N, Ohno S, Kiyokawa E, Umeda M, Kobayashi T. (2003) Oligomerization and pore formation of a sphingomyelin-specific toxin, lysenin. J. Biol. Chem. 278, 22762 - 22770.

Nagatsuka Y, Hara-Yokoyama M, Kasama T, Takekoshi M, Maeda F, Ihara S, Fujiwara S, Ohshima E, Ishii K, Kobayashi T, Shimizu K, Hirabayashi Y. (2003) Carbohydrate-dependent signaling from the phosphatidylglucoside-based microdomain induces granulocytic differentiation of HL60 cells. Proc. Natl. Acad. Sci. USA 100, 7454-7459.