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Members

Takao Ono, Ph. D.

Education

1983-89 Hirosaki University, Hirosaki, Aomori, Japan.
B. S., Biology, 1987
1989-95 Hokkaido University, Sapporo, Japan.
Ph. D., Zoology, 1995

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Research and Professional Experience

1995-96 Lecturer, Department of Medical Technology Hokkaido Prefectural School of Hygiene, Sapporo, Japan.
1996-02 Researcher, Department of Genetics, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, Japan.
2002-04 Visiting Scientist, Cold Spring Harbor Laboratory, U.S.A.
2004-06 Senior Researcher, Department of Genetics, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, Japan.
2004-06 Lecturer, School of Nursing, Aichi Prefectural College of Nursing and Health, Nagoya, Aichi, Japan.
2007-present Senior Research Scientist, RIKEN, Japan.

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Awards and Professional Activities

Professional Activities

2007- Editorial board, Chromosome Science (The Society of Chromosome Research)
2008 Member of the committee for The 4th Asian Chromosome Colloquium 2008, Osaka, Japan
2008-10 Grant-in-Aid for Chromosome Cycle (20055021)
2009 Member of the committee for The 60th Annual Meeting of the Society of Chromosome Research, Matsue, Shimane, Japan

Awards

2000 Prize for Poster Presentation from the Japanese Teratology Society
2005 Award for Chromosome study from the Society of Chromosome Research

Academic Society

1988- Member, The Society of Chromosome Research, Japan
2004- Member, The Japan Society of Human Genetics
2005- Member, The Molecular Biology Society of Japan

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Publication List

  • Fukuda, K., T. Shimi, C. Shimura, T. Ono, T. Suzuki, K. Onoue, S. Okayama, H. Miura, I. Hiratani, K. Ikeda, Y. Okada, N. Dohmae, S. Yonemura, A. Inoue, H. Kimura and Y. Shinkai. (2023). Epigenetic plasticity safeguards heterochromatin configuration in mammals. Nucleic Acids Res. 51:gkad387.
    PMID: 37178005
  • Takagi, M., T. Ono, T. Natsume, C. Sakamoto, M. Nakao, N. Saitoh, M. T. Kanemaki, T. Hirano and N. Imamoto. (2018). Ki-67 and condensins support the integrity of mitotic chromosomes through distinct mechanisms. J Cell Sci. 131: jcs212092 doi: 10.1242.
    PMID: 29487178
  • Ono, T., C. Sakamoto, M. Nakao, N. Saitoh and T. Hirano. (2017). Condensin II plays an essential role in reversible assembly of mitotic chromosomes in situ. Mol Biol Cell. 28:2875-2886.
    PMID: 28835373
  • Ono, T., D. Yamashita and T. Hirano. (2013). Condensin II initiates sister chromatid resolution during S phase. J Cell Biol. 200:429-441.
    PMID: 23401001
  • Shiheido, H., Y. Naito, H. Kimura, H. Genma, H. Takashima, T. Ono, T. Hirano, W. Du, T. Yamada, N. Doi, S. Iijima, Y. Hattori and H. Yanagawa. (2012). An anilinoquinazoline derivative inhibits tumor growth through interaction with hCAP-G2, a subunit of condensin II. PLoS One. 7:e44889.
    PMID: 23028663
  • Yamashita, D., K. Shintomi, T. Ono, I. Gavvovidis, D. Schindler, H. Neitzel, M. Trimborn and T. Hirano. (2011). MCPH1 regulates chromosome condensation and shaping as a composite modulator of condensin II. J Cell Biol. 194:841-854.
    PMID: 21911480
  • Kamamoto, M., J. Machida, H. Miyachi, T. Ono, A. Nakayama, K. Shimozato and Y. Tokita. (2010). A novel mutation in the C-terminal region of RUNX2/CBFA1 distal to the DNA-binding runt domain in a Japanese patient with cleidocranial dysplasia. Int J Oral Maxillofac Surg. 40:434-437.
    PMID: 21115325
  • Yamada, K., D. Fukushi, T. Ono, Y. Kondo, R. Kimura, N. Nomura, K.J. Kosaki, Y. Yamada, S. Mizuno and N. Wakamatsu. (2010). Characterization of a de novo balanced t(4;20)(q33;q12) translocation in a patient with mental retardation. Am J Med Genet A. 152A:3057-3067.
    PMID: 21086493
  • Machida, J., T.M. Felix, J.C. Murray, K. Yoshiura, M. Tanemura, M. Kamamoto, K. Shimozato, S. Sonta and T. Ono. (2009). Searching for genes for cleft lip and/or palate based on breakpoint analysis of a balanced translocation t(9;17)(q32;q12). Cleft Palate Craniofac J. 46:532-540.
    PMID: 19929093
  • Ono, T., Y. Fang, D.L. Spector and T. Hirano. (2004). Spatial and temporal regulation of condensins I and II in mitotic chromosome assembly in human cells. Mol Biol Cell. 15:3296-3308.
    PMID: 15146063
  • Ono, T., A. Losada, M. Hirano, M.P. Myers, A.F. Neuwald and T. Hirano T. (2003). Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells. Cell. 115:109-121.
    PMID: 14532007
  • Wakamatsu, N., Y. Yamada, K. Yamada, T. Ono, N. Nomura, H. Taniguchi, H. Kitoh, N. Mutoh, T. Yamanaka, K. Mushiake, K. Kato, S. Sonta and M. Nagaya. (2001). Mutations in SIP1, encoding Smad interacting protein-1, cause a form of Hirschsprung disease. Nat Genet. 27:369-370.
    PMID: 11279515
  • Ono, T., Y. Kondoh, N. Kagiyama, S. Sonta and M.C. Yoshida. (2001). Genomic organization and chromosomal distribution of rat ID elements. Genes Genet Syst. 76:213-220.
    PMID: 11732629
  • Ono, T. and S. Sonta. (2001). Chromosome map of cosmid clones constructed with Chinese hamster genomic DNA. Cytogenet Cell Genet. 95:97-102.
    PMID: 11978978
  • Rogatcheva, M.B., T. Ono, S. Sonta, S. Oda and P.M. Borodin. (2000). Robertsonian metacentrics of the house musk shrew (Suncus murinus, Insectivora, Soricidae) lose the telomeric sequences in the centromeric area. Genes Genet Syst. 75:155-158.
    PMID: 10984840
  • Ono, T., S. Hirano, S. Yonezawa, S. Aono, M. Osaki, S. Masaki, S. Yamashita, T. Tsukasaki, A. Oohira A, S.T. Suzuki and S. Sonta. (2000). Comparative mapping of seven genes in mouse, rat and Chinese hamster chromosomes by fluorescence in situ hybridization. Cytogenet Cell Genet. 89:209-213.
    PMID: 10965124
  • Aono, S., H. Keino, T. Ono, Y. Yasuda, Y. Tokita, F. Matsui, M. Taniguchi, S. Sonta and A. Oohira. (2000). Genomic Organization and Expression Pattern of Mouse Neuroglycan C in the Cerebellar Development. J Biol Chem. 275:337-342.
    PMID: 10617623
  • Hirano, S., T. Ono, Q. Yan, X. Wang, S. Sonta and S.T. Suzuki. (1999). Protocadherin 2C: a new member of the protocadherin 2 subfamily expressed in a redundant manner with OL-protocadherin in the developing brain. Biochem Biophys Res Comm. 260:641-645.
    PMID: 10403819
  • Sumiyama, K., K. Washio-Watanabe, T. Ono, M.C. Yoshida, T. Hayakawa and S. Ueda. (1998). Human class III POU genes, POU3F1 and POU3F3, map to chromosome 1p34.1 and 3p14.2. Mamm Genome. 9:180-181.
    PMID: 9457692
  • Okamoto, T., T. Ono, M. Hori, J.P. Jang, T. Tetsuka, T. Kawabe and S. Sonta. (1998). Assignment of the IkBβgene NFKBIB to human chromosome band 19q13.1 by in situ hybridization. Cytogenet Cell Genet. 82:105-106.
    PMID: 9763672
  • Yasuda, Y., Y. Tokita, S. Aono, S., F. Matsui, T. Ono, S. Sonta, E. Watanabe, Y. Nakanishi and Oohira, A. (1998). Cloning and chromosomal mapping of the human gene of neuroglycan C (NGC), a neural transmembrane chondrotin sulfate proteoglycan with an EGF module. Neurosci Res. 32:313-322.
    PMID: 9950058
  • Ono, T. and M.C. Yoshida. (1997). Differences in the chromosomal distribution of telomeric (TTAGGG)n sequences in two species of the vespertilionid bats. Chrom Res. 5:203-212.
    PMID: 9246415
  • Ono, T., T. Kawabe, S. Sonta and T. Okamoto. (1997). Assignment of MARK3 alias KP78 to human chromosome band 14q32.3 by in situ hybridization. Cytogenet Cell Genet. 79: 101-102.
    PMID: 9533022
  • Yang, J.P., T. Ono, S. Sonta, T. Kawabe and T. Okamoto. (1997). Assignment of p53 binding protein (TP53BP2) to human chromosome band 1q42.1 by in situ hybridization. Cytogenet Cell Genet. 78:61-62.
    PMID: 9345910
  • Ono, T., R. Fukumoto, Y. Kondoh and M.C. Yoshida. (1995). Deletion of the Wilson's disease gene in hereditary hepatitis LEC rats. Jpn J Genet. 70:25-33.
    PMID: 7772379
  • Kondoh, Y., T. Ono, N. Kagiyama, M. Fujita, M. Momiyama, S.H. Hori and M.C. Yoshida. (1995). Simultaneous visualization of Q-bands and FISH signals using a novel fluorochrome. Cytogenet Cell Genet. 71:96-98.
    PMID: 7606937
  • Ono, T., S. Takada and M.C. Yoshida. (1994). The WD gene for Wilson's disease links to the hepatitis of LEC rats. Jpn J Cancer Res. 85: 771-774.
    PMID: 7928621
  • Ono, T. and M.C. Yoshida. (1993). Chromosomal assignment of retinoblastoma 1 gene (RB1) to mouse14D3 and rat 15q12 by fluorescence in situ hybridization. Jpn J Genet. 8:617-621.
    PMID: 8031579
  • Chiba, H., N. Sawada, T. Ono, S. Ishii and M. Mori. (1993). Establishment and characterization of a Simian Virus 40-immortalized osteoblastic cell line from normal human bone. Jpn J Cancer Res. 84:290-297.
    PMID: 8387478
  • Sone, H., M. Maeda, M. Gotoh, K. Wakabayashi, T. Ono, M.C. Yoshida, N. Takeichi, M. Mori, S. Hirohashi, T. Sugimura and M. Nagao (1992). Genetic linkage between copper accumulation and hepatitis/hepatoma development in LEC rats. Mol Carcinog. 5: 199-204.
    PMID: 1316758
  • Ono, T., S. Abe and M.C. Yoshida (1991). Hereditary low level of plasma ceruloplasmin in LEC rats associated with spontaneous development of hepatitis and liver cancer. Jpn J Cancer Res. 82:486-489.
    PMID: 1905693

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Chromosome Dynamics Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan
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