Kazuhisa Kinoshita, Ph. D.
Education
| 1989-93 | Tohoku University, Sendai, Japan. B. S., Biology, 1993 |
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| 1993-95 | Kyoto University, Kyoto, Japan. M. S., Molecular Biology, 1995 |
| 1995-98 | Kyoto University, Kyoto, Japan. Ph. D., Molecular Biology, 1998 |
Research and Professional Experience
| 1998-2000 | Postdoctoral Fellow, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany |
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| 2000-01 | Postdoctoral Fellow, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany |
| 2001-06 | Staff Scientist, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany |
| 2006-07 | Research Scientist, Kyoto University, Kyoto, Japan |
| 2007-present | Senior Research Scientist, RIKEN, Wako, Japan |
Awards and Professional Activities
| 1998 | Research Fellowship of the Japan Society for the Promotion of Science |
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| 1998-2000 | Long-Term Fellowship of the Human Frontier Science Program |
| 2002 | Research Fellowship of the Uehara Memorial Foundation |
| 2004- | Member, The Molecular Biology Society of Japan |
Publication List
- Hirano, T. and K. Kinoshita. (2025). SMC-mediated chromosome organization: Does loop extrusion explain it all? Curr Opin Cell Biol. 92:102447.
PMID: 39603149 - Yoshida, M. M., K. Kinoshita, K. Shintomi, Y. Aizawa and T. Hirano. (2024). Regulation of condensin II by self-suppression and release mechanisms. Mol Biol Cell. 35:ar21.
PMID: 38088875 - Yamamoto, T., K. Kinoshita and T. Hirano. (2023). Elasticity control of entangled chromosomes: Crosstalk between condensin complexes and nucleosomes. Biophys J. 122:3869-3881.
PMID: 37571823 - Tane, S., K. Shintomi, K. Kinoshita, Y. Tsubota, M. M. Yoshida, T. Nishiyama and T. Hirano. (2022). Cell cycle-specific loading of condensin I is regulated by the N-terminal tail of its kleisin subunit. eLife. 11:e84694.
PMID: 36511239 - Yoshida, M. M., K. Kinoshita, Y. Aizawa, S. Tane, D. Yamashita, K. Shintomi and T. Hirano. (2022). Molecular dissection of condensin II-mediated chromosome assembly using in vitro assays. eLife. 11:e78984.
PMID: 35983835 - Kinoshita, K., Y. Tsubota, S. Tane, Y. Aizawa, R. Sakata, K. Takeuchi, K. Shintomi, T. Nishiyama and T. Hirano. (2022). A loop extrusion-independent mechanism contributes to condensin I-mediated chromosome shaping. J Cell Biol. 221:e202109016.
PMID: 35045152 - Hara, K., K. Kinoshita, T. Migita, K. Murakami, K. Shimizu, K. Takeuchi, T. Hirano and H. Hashimoto. (2019). Structural basis of HEAT-kleisin interactions in the human condensin I subcomplex. EMBO Rep. 20:e47183.
PMID: 30858338 - Sakai, Y., A. Mochizuki, K. Kinoshita, T. Hirano and M. Tachikawa. (2018). Modeling the functions of condensin in chromosome shaping and segregation. PLoS Comput Biol. 14:e1006152.
PMID: 29912867 - Kinoshita, K. and T. Hirano. (2017). Dynamic organization of mitotic chromosomes. Curr Opin Cell Biol. 46:46-53.
PMID: 28214612 - Kinoshita, K., T. J. Kobayashi and T. Hirano. (2015). Balancing acts of two HEAT subunits of condensin I support dynamic assembly of chromosome axes. Dev Cell. 33:94-106.
PMID: 25850674 - Brunet, S., J. Dumont, K. W. Lee, K. Kinoshita, P. Hikal, O. J. Gruss, B. Maro and M. -H. Verlhac. (2008). Meiotic regulation of TPX2 protein levels governs cell cycle progression in mouse oocytes. PLoS One. 3:e3338.
PMID: 18833336 - Brouhard, G. J., J. H. Stear, T. L. Noetzel, J. Al-Bassam, K. Kinoshita, S. C. Harrison, J. Howard and A. A. Hyman. (2008). XMAP215 is a processive microtubule polymerase. Cell. 132:79-88.
PMID: 18191222 - Mori, D., Y. Yano, K. Toyo-oka, N. Yoshida, M. Yamada, M. Muramatsu, D. Zhang, H. Saya, Y. Y. Toyoshima, K. Kinoshita, A. Wynshaw-Boris and S. Hirotsune. (2007). NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation and TACC3 recruitment. Mol Cell Biol. 27:352-367.
PMID: 17060449 - Aoki, K., Y. Nakaseko, K. Kinoshita, G. Goshima and M. Yanagida. (2006). Cdc2 phosphorylation of the fission yeast Dis1 ensures accurate chromosome segregation. Curr Biol. 16:1627-1635.
PMID: 16920624 - Kinoshita, K., T. L. Noetzel, I. Arnal, D. N. Drechsel and A. A. Hyman. (2006). Global and local control of the microtubule destabilizing activity of a catastrophe kinesin MCAK/XKCM1. J Muscle Res Cell Motil. 27:107-114.
PMID: 16450057 - Kinoshita, K., T. L. Noetzel, L. Pelletier, K. Mechtler, D. N. Drechsel, A. Schwager, M. Lee, J. W. Raff and A. A. Hyman. (2005). Aurora A phosphorylation of TACC3/Maskin is required for centrosome-dependent microtubule assembly in mitosis. J Cell Biol. 170:1047-1055.
PMID: 16172205 - Barros, T. P., K. Kinoshita, A. Hyman and J. W. Raff. (2005). Aurora A kinase activates D-TACC/Msps complexes exclusively at centrosomes during mitosis to stabilize astral microtubules. J Cell Biol. 170:1039-1046.
PMID: 16186253 - Özlü, N., M. Srayko, K. Kinoshita, B. Habermann, E. T. O’ Toole, T. Müller-Reichert, N. Schmalz, A. Desai and A. A. Hyman. (2005). An essential function of the C. elegans ortholog of TPX2 is to localize activated Aurora A kinase to mitotic spindles. Dev Cell. 9:237-248.
PMID: 16054030 - Noetzel, T. L., D. N. Drechsel, A. A. Hyman and K. Kinoshita. (2005). A comparison of the ability of XMAP215 and tau to inhibit the microtubule destabilizing activity of XKCM1. Philos Trans R Soc Lond B Biol Sci. 360:591-594.
PMID: 15905143 - Schaar, B. T., K. Kinoshita and S. K. McConnell. (2004). Doublecortin microtubule affinity is regulated by a balance of kinase and phosphatase activity at the leading edge of migrating neurons. Neuron. 41:203-213.
PMID: 14741102 - Kinoshita, K., B. Habermann and A. A. Hyman. (2002). XMAP215: a key component of the dynamic microtubule cytoskeleton. Trends Cell Biol. 12:267-273.
PMID: 12074886 - Kinoshita, K., I. Arnal, A. Desai, D. N. Drechsel and A. A. Hyman. (2001). Reconstitution of physiological microtubule dynamics using purified components. Science. 294:1340-1343.
PMID: 11701928 - Popov, A. V., A. Pozniakovsky, I. Arnal, C. Antony, A. J. Ashford, K. Kinoshita, R. Tournebize, A. A. Hyman and E. Karsenti. (2001). XMAP215 regulates microtubule dynamics through two distinct domains. EMBO J. 20:397-410.
PMID: 11157747 - Zumbrunn, J., K. Kinoshita, A. A. Hyman and I. S. Nathke. (2001). Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation. Curr Biol. 11:44-49.
PMID: 11166179 - Tatebe, H., G. Goshima, K. Takeda, T. Nakagawa, K. Kinoshita and M. Yanagida. (2001). Fission yeast living mitosis visualized by GFP-tagged gene products. Micron. 32:67-74.
PMID: 10900382 - Tournebize, R., A. Popov, K. Kinoshita, A. J. Ashford, S. Rybina, A. Pozniakovsky, T. U. Mayer, C. E. Walczak, E. Karsenti and A. A. Hyman. (2000). Control of microtubule dynamics by the antagonistic activities of XMAP215 and XKCM1 in Xenopus egg extracts. Nat Cell Biol. 2:13-19.
PMID: 10620801 - Nakaseko, Y., K. Nabeshima, K. Kinoshita and M. Yanagida. (1996). Dissection of fission yeast microtubule associating protein p93Dis1: regions implicated in localization and microtubule interaction. Genes Cells. 1:633-644.
PMID: 9078390 - Kinoshita, K., T. Nemoto, K. Nabeshima, H. Kondoh, H. Niwa and M. Yanagida. (1996). The regulatory subunits of fission yeast protein phosphatase 2A (PP2A) affect cell morphogenesis, cell wall synthesis and cytokinesis. Genes Cells. 1:29-45.
PMID: 9078365 - Nabeshima, K., H. Kurooka, M. Takeuchi, K. Kinoshita, Y. Nakaseko and M. Yanagida. (1995). p93dis1, which is required for sister chromatid separation, is a novel microtubule and spindle pole body-associating protein phosphorylated at the Cdc2 target sites. Genes Dev. 9:1572-1585.
PMID: 7628693
