Papers

2023

  • Iyer KR, Li SC, Revie NM, Lou JW, Duncan D, Fallah S, Sanchez H, Skulska I, Usaj MM, Safizadeh H, Larsen B, Wong C, Aman A, Kiyota Y, Yoshimura M, Kimura H, Hirano H, Yoshida M, Osada H, Gingras AC, Andes DR, Shapiro RS, Robbins N, Mazhab-Jafari MT, Whitesell L, Yashiroda Y, Boone C, Cowen LE.
    Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity.
    Cell Chem Biol. 2023 30:1-16. doi: 10.1016/j.chembiol.2023.06.005.


  • Saeki N, Yamamoto C, Eguchi Y, Sekito T, Shigenobu S, Yoshimura M, Yashiroda Y, Boone C, Moriya H.
    Overexpression profiling reveals cellular requirements in the context of genetic backgrounds and environments.
    PLoS Genet. 2023 19(4):e1010732. doi: 10.1371/journal.pgen.1010732.


  • Messner CB, Demichev V, Muenzner J, Aulakh SK, Barthel N, Röhl A, Herrera-Domínguez L, Egger AS, Kamrad S, Hou J, Tan G, Lemke O, Calvani E, Szyrwiel L, Mülleder M, Lilley KS, Boone C, Kustatscher G, Ralser M.
    The proteomic landscape of genome-wide genetic perturbations.
    Cell. 2023 186(9):2018-2034.e21. doi: 10.1016/j.cell.2023.03.026.


2022

  • Forster DT, Li SC, Yashiroda Y, Yoshimura M, Li Z, Isuhuaylas LAV, Itto-Nakama K, Yamanaka D, Ohya Y, Osada H, Wang B, Bader GD, Boone C.
    BIONIC: biological network integration using convolutions.
    Nat Methods. 2022 19(10):1250-1261. doi:10.1038/s41592-022-01616-x.


  • Sasaki M, Nishimura S, Yashiroda Y, Matsuyama A, Kakeya H, Yoshida M.
    FK506 binding protein, FKBP12, promotes serine utilization and negatively regulates threonine deaminase in fission yeast.
    iScience. 2022 25:105659. doi:10.1016/j.isci.2022.105659.


  • Chiu P, Nakamura Y, Nishimura S, Tabuchi T, Yashiroda Y, Hirai G, Matsuyama A, Yoshida M.
    Ferrichrome, a fungal-type siderophore, confers high ammonium tolerance to fission yeast.
    Scientific Reports. 2022 12:17411. doi:10.1038/s41598-022-22108-0.


  • Ueoka R, Sondermann P, Leopold-Messer S, Liu Y, Suo R, Bhushan A, Vadakumchery L, Greczmiel U, Yashiroda Y, Kimura H, Nishimura S, Hoshikawa Y, Yoshida M, Oxenius A, Matsunaga S, Williamson RT, Carreira EM, Piel J.
    Genome-based discovery and total synthesis of janustatins, potent cytotoxins from a plant-associated bacterium.
    Nature chemistry. 2022 14:1193–1201. doi:10.1038/s41557-022-01020-0.


  • Sato H, Murakami T, Matsuura R, Abe M, Matsuoka S, Yashiroda Y, Yoshida M, Akari H, Nagasawa Y, Takei M, Aida Y.
    A Novel Class of HIV-1 Inhibitors Targeting the Vpr-Induced G2-Arrest in Macrophages by New Yeast- and Cell-Based High-Throughput Screening.
    Viruses. 2022 14(6):1321. doi: 10.3390/v14061321.


  • Du Bois AC, Xue A, Pham C, Revie NM, Meyer KJ, Yashiroda Y, Boone C, Nodwell JR, Stogios P, Savchenko A, Robbins N, Iyer KR, Cowen LE.
    High-Throughput Chemical Screen Identifies a 2,5-Disubstituted Pyridine as an Inhibitor of Candida albicans Erg11.
    mSphere. 2022 7(3). doi:10.1128/msphere.00075-22.


  • Revie NM, Iyer KR, Maxson ME, Zhang J, Yan S, Fernandes CM, Meyer KJ, Chen X, Skulska I, Fogal M, Sanchez H, Hossain S, Li S, Yashiroda Y, Hirano H, Yoshida M, Osada H, Boone C, Shapiro RS, Andes DR, Wright GD, Nodwell JR, Del Poeta M, Burke MD, Whitesell L, Robbins N, Cowen LE.
    Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation.
    Nat Commun. 2022 13(1):3634. doi:10.1038/s41467-022-31308-1.


  • Dhital RN, Sen A, Hu H, Ishii R, Sato T, Yashiroda Y, Kimura H, Boone C, Yoshida M, Futamura Y, Hirano H, Osada H, Hashizume D, Uozumi Y, Yamada YMA.
    Phenylboronic Ester-Activated Aryl Iodide-Selective Buchwald−Hartwig-Type Amination toward Bioactivity Assay.
    ACS Omega. 2022 7(28):24184. doi: 10.1021/acsomega.2c01092.


  • Ohnuki S, Ogawa I, Itto-Nakama K, Lu F, Ranjan A, Kabbage M, Gebre AA, Yamashita M, Li SC, Yashiroda Y, Yoshida S, Usui T, Piotrowski JS, Andrews BJ, Boone C, Brown GW, Ralph J, Ohya Y.
    High-throughput platform for yeast morphological profiling predicts the targets of bioactive compounds.
    NPJ Syst Biol Appl. 2022 8(1):3. doi: 10.1038/s41540-022-00212-1.


  • Kubo K, Itto-Nakama K, Ohnuki S, Yashiroda Y, Li SC, Kimura H, Kawamura Y, Shimamoto Y, Tominaga KI, Yamanaka D, Adachi Y, Takashima S, Noda Y, Boone C, Ohya Y.
    Jerveratrum-type steroidal alkaloids inhibit β-1,6-glucan biosynthesis in fungal cell walls.
    Microbiol Spectr. 2022 10(1):e0087321. doi: 10.1128/spectrum.00873-21. Epub 2022 Jan 12.


  • Persaud R, Li SC, Chao JD, Forestieri R, Donohue E, Balgi AD, Zheng X, Chao JT, Yashiroda Y, Yoshimura M, Loewen CJR, Gingras AC, Boone C, Av-Gay Y, Roberge M, Andersen RJ.
    Clionamines stimulate autophagy, inhibit Mycobacterium tuberculosis survival in macrophages, and target Pik1.
    Cell Chem Biol. 2022 29(5):870. doi: 10.1016/j.chembiol.2021.07.017.


2021

2020

2019

2018

2017

  • Piotrowski JS, Li SC, Deshpande R, Simpkins SW, Nelson J, Yashiroda Y, Barber JM, Safizadeh H, Wilson E, Okada H, Gebre AA, Kubo K, Torres NP, LeBlanc MA, Andrusiak K, Okamoto R, Yoshimura M, van Leeuwen J, Shirahige K, Baryshnikova A, Brown GW, Hirano H, Costanzo M, Andrews B, Ohya Y, Osada H, Yoshida M, Myers CL, Boone C.
    Functional Annotation of Chemical Libraries across Diverse Biological Processes.
    Nat Chem Biol. 2017 13(9):982-993.

  • Sideri T, Yashiroda Y, Ellis DA, Rodríguez-López M, Yoshida M, Tuite MF, Bähler J.
    The copper transport-associated protein Ctr4 can form prion-like epigenetic determinants in Schizosaccharomyces pombe.
    Microb Cell. 2017 4(1):16-28.

  • Li G, Poulsen M, Fenyvuesvolgyi C, Yashiroda Y, Yoshida M, Simard JM, Gallo RC, Zhao RY.
    Characterization of cytopathic factors through genome-wide analysis of the Zika viral proteins in fission yeast.
    Proc Natl Acad Sci U S A. 2017 114(3):E376-E385.

2016

  • Costanzo M, VanderSluis B, Koch EN, Baryshnikova A, Pons C, Tan G, Wang W, Usaj M, Hanchard J, Lee SD, Pelechano V, Styles EB, Billmann M, van Leeuwen J, van Dyk N, Lin ZY, Kuzmin E, Nelson J, Piotrowski JS, Srikumar T, Bahr S, Chen Y, Deshpande R, Kurat CF, Li SC, Li Z, Usaj MM, Okada H, Pascoe N, San Luis BJ, Sharifpoor S, Shuteriqi E, Simpkins SW, Snider J, Suresh HG, Tan Y, Zhu H, Malod-Dognin N, Janjic V, Przulj N, Troyanskaya OG, Stagljar I, Xia T, Ohya Y, Gingras AC, Raught B, Boutros M, Steinmetz LM, Moore CL, Rosebrock AP, Caudy AA, Myers CL, Andrews B, Boone C.
    A global genetic interaction network maps a wiring diagram of cellular function.
    Science. 2016 353(6306). pii: aaf1420.

  • Sun X, Hirai G, Ueki M, Hirota H, Wang Q, Hongo Y, Nakamura T, Hitora Y, Takahashi H, Sodeoka M, Osada H, Hamamoto M, Yoshida M, Yashiroda Y.
    Identification of novel secreted fatty acids that regulate nitrogen catabolite repression in fission yeast.
    Sci Rep. 2016 6:20856.

  • Dickinson Q, Bottoms S, Hinchman L, McIlwain S, Li S, Myers CL, Boone C, Coon JJ, Hebert A, Sato TK, Landick R, Piotrowski JS.
    Mechanism of imidazolium ionic liquids toxicity in Saccharomyces cerevisiae and rational engineering of a tolerant, xylose-fermenting strain.
    Microb Cell Fact. 2016 15:17.


2015

  • Serate J, Xie D, Pohlmann E, Donald C Jr, Shabani M, Hinchman L, Higbee A, Mcgee M, La Reau A, Klinger GE, Li S, Myers CL, Boone C, Bates DM, Cavalier D, Eilert D, Oates LG, Sanford G, Sato TK, Dale B, Landick R, Piotrowski J, Ong RG, Zhang Y.
    Controlling microbial contamination during hydrolysis of AFEX-pretreated corn stover and switchgrass: effects on hydrolysate composition, microbial response and fermentation.
    Biotechnol Biofuels. 2015 8:180.


  • Piotrowski JS, Okada H, Lu F, Li SC, Hinchman L, Ranjan A, Smith DL, Higbee AJ, Ulbrich A, Coon JJ, Deshpande R, Bukhman YV, McIlwain S, Ong IM, Myers CL, Boone C, Landick R, Ralph J, Kabbage M, Ohya Y.
    Plant-derived antifungal agent poacic acid targets β-1,3-glucan.
    Proc Natl Acad Sci U S A. 2015 112(12):E1490-7.


  • Piotrowski JS, Simpkins SW, Li SC, Deshpande R, McIlwain SJ, Ong IM, Myers CL, Boone C, Andersen RJ.
    Chemical genomic profiling via barcode sequencing to predict compound mode of action.
    Methods Mol Biol. doi: 10.1007/978-1-4939-2269-7_23.2015;1263:299-318.



2014

  • Fung SY, Sofiyev V, Schneiderman J, Hirschfeld AF, Victor RE, Woods K, Piotrowski JS, Deshpande R, Li SC, de Voogd NJ, Myers CL, Boone C, Andersen RJ, Turvey SE.
    Unbiased screening of marine sponge extracts for anti-inflammatory agents combined with chemical genomics identifies girolline as an inhibitor of protein synthesis.
    ACS Chem Biol. 2014 9(1):247-57. doi: 10.1021/cb400740c. Epub 2013 Oct 29.


2013

  • Deshpande R, Asiedu MK, Klebig M, Sutor S, Kuzmin E, Nelson J, Piotrowski J, Shin SH, Yoshida M, Costanzo M, Boone C, Wigle DA, Myers CL.
    A comparative genomic approach for identifying synthetic lethal interactions in human cancer.
    Cancer Res. 2013 73(20):6128-36.


  • Yoshida M, Ohnuki S, Yashiroda Y, Ohya Y.
    Profilin is required for Ca2+ homeostasis and Ca2+-modulated bud formation in yeast.
    Mol Genet Genomics. 2013 288(7-8):317-28.


2012

2011

2010

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