Diehl C, Pinzan CF, de Castro PA, Delbaje E, Carnero LCG, Sánchez-León E, Bhalla K, Kronstad JW, Kim D-g, Doering TL, Alkhazraji S, Mishra NN, Ibrahim AS, Yoshimura M, Isuhuaylas LAV, Pham LTK, Yashiroda Y, Boone C, dos Reis TF, Goldman GH
Brilacidin, a novel antifungal agent against Cryptococcus neoformans. mBio. 2024 15:e0103124. doi: 10.1128/mbio.01031-24.
Pünner F, Sohtome Y, Lyu Y, Hashizume D, Akakabe M, Yoshimura M, Yashiroda Y, Yoshida M, Sodeoka M
Catalytic Aerobic Carbooxygenation for Construction of Vicinal Tetrasubstituted Centers: Application to the Synthesis of Hexa-substituted γ-Lactones. Angewandte Chemie International Edition. 2024 doi: 10.1002/anie.202405876.
Liu Z, Yashiroda Y, Sun P, Ma H, Wang Y, Li L, Yan F, Yi Sun Y.
Argenteolides A and B, Glycosylated Polyketide–Peptide Hybrid Macrolides from an Actinomycete Streptomyces argenteolus. Org. Lett. 2023 25:571-575. doi: 10.1021/acs.orglett.2c03290.
Iyer KR, Li SC, Revie NM, Lou JW, Duncan D, Fallah S, Sanchez H, Skulska I, Usaj MM, Safizadeh H, Larsen B, Wong C, Aman A, Kiyota Y, Yoshimura M, Kimura H, Hirano H, Yoshida M, Osada H, Gingras AC, Andes DR, Shapiro RS, Robbins N, Mazhab-Jafari MT, Whitesell L, Yashiroda Y, Boone C, Cowen LE.
Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity. Cell Chem Biol. 2023 30:1-16. doi: 10.1016/j.chembiol.2023.06.005.
Saeki N, Yamamoto C, Eguchi Y, Sekito T, Shigenobu S, Yoshimura M, Yashiroda Y, Boone C, Moriya H.
Overexpression profiling reveals cellular requirements in the context of genetic backgrounds and environments. PLoS Genet. 2023 19(4):e1010732. doi: 10.1371/journal.pgen.1010732.
Messner CB, Demichev V, Muenzner J, Aulakh SK, Barthel N, Röhl A, Herrera-Domínguez L, Egger AS, Kamrad S, Hou J, Tan G, Lemke O, Calvani E, Szyrwiel L, Mülleder M, Lilley KS, Boone C, Kustatscher G, Ralser M.
The proteomic landscape of genome-wide genetic perturbations. Cell. 2023 186(9):2018-2034.e21. doi: 10.1016/j.cell.2023.03.026.
Sasaki M, Nishimura S, Yashiroda Y, Matsuyama A, Kakeya H, Yoshida M.
FK506 binding protein, FKBP12, promotes serine utilization and negatively regulates threonine deaminase in fission yeast. iScience. 2022 25:105659. doi:10.1016/j.isci.2022.105659.
Ueoka R, Sondermann P, Leopold-Messer S, Liu Y, Suo R, Bhushan A, Vadakumchery L, Greczmiel U, Yashiroda Y, Kimura H, Nishimura S, Hoshikawa Y, Yoshida M, Oxenius A, Matsunaga S, Williamson RT, Carreira EM, Piel J.
Genome-based discovery and total synthesis of janustatins, potent cytotoxins from a plant-associated bacterium. Nature chemistry. 2022 14:1193–1201. doi:10.1038/s41557-022-01020-0.
Sato H, Murakami T, Matsuura R, Abe M, Matsuoka S, Yashiroda Y, Yoshida M, Akari H, Nagasawa Y, Takei M, Aida Y.
A Novel Class of HIV-1 Inhibitors Targeting the Vpr-Induced G2-Arrest in Macrophages by New Yeast- and Cell-Based High-Throughput Screening. Viruses. 2022 14(6):1321. doi: 10.3390/v14061321.
Du Bois AC, Xue A, Pham C, Revie NM, Meyer KJ, Yashiroda Y, Boone C, Nodwell JR, Stogios P, Savchenko A, Robbins N, Iyer KR, Cowen LE.
High-Throughput Chemical Screen Identifies a 2,5-Disubstituted Pyridine as an Inhibitor of Candida albicans Erg11. mSphere. 2022 7(3). doi:10.1128/msphere.00075-22.
Revie NM, Iyer KR, Maxson ME, Zhang J, Yan S, Fernandes CM, Meyer KJ, Chen X, Skulska I, Fogal M, Sanchez H, Hossain S, Li S, Yashiroda Y, Hirano H, Yoshida M, Osada H, Boone C, Shapiro RS, Andes DR, Wright GD, Nodwell JR, Del Poeta M, Burke MD, Whitesell L, Robbins N, Cowen LE.
Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation. Nat Commun. 2022 13(1):3634. doi:10.1038/s41467-022-31308-1.
Dhital RN, Sen A, Hu H, Ishii R, Sato T, Yashiroda Y, Kimura H, Boone C, Yoshida M, Futamura Y, Hirano H, Osada H, Hashizume D, Uozumi Y, Yamada YMA.
Phenylboronic Ester-Activated Aryl Iodide-Selective Buchwald−Hartwig-Type Amination toward Bioactivity Assay. ACS Omega. 2022 7(28):24184. doi: 10.1021/acsomega.2c01092.
Ohnuki S, Ogawa I, Itto-Nakama K, Lu F, Ranjan A, Kabbage M, Gebre AA, Yamashita M, Li SC, Yashiroda Y, Yoshida S, Usui T, Piotrowski JS, Andrews BJ, Boone C, Brown GW, Ralph J, Ohya Y.
High-throughput platform for yeast morphological profiling predicts the targets of bioactive compounds. NPJ Syst Biol Appl. 2022 8(1):3. doi: 10.1038/s41540-022-00212-1.
Fu C, Zhang X, Veri AO, Iyer KR, Lash E, Xue A, Yan H, Revie NM, Wong C, Lin ZY, Polvi EJ, Liston SD, VanderSluis B, Hou J, Yashiroda Y, Gingras AC, Boone C, O'Meara TR, O'Meara MJ, Noble S, Robbins N, Myers CL, Cowen LE.
Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets. Nat Commun. 2021 12(1):6497. doi: 10.1038/s41467-021-26850-3.
Tomita K, Yashiroda Y, Matsuo Y, Piotrowski JS, Li SC, Okamoto R, Yoshimura M, Kimura H, Kawamura Y, Kawamukai M, Boone C, Yoshida M, Nojiri H, Okada K.
Genome-wide screening of genes associated with momilactone B sensitivity in the fission yeast Schizosaccharomyces pombe. G3 (Bethesda). 2021 11(8):jkab156. doi: 10.1093/g3journal/jkab156.
Safizadeh H, Simpkins, SW, Nelson J, Li SC, Piotrowski JS, Yoshimura M, Yashiroda Y, Hirano H, Osada H, Yoshida M, Boone M, Myers CL.
Improving measures of chemical structural similarity using machine learning on chemical-genetic interactions. J Chem Inf Model. 2021 61(9):4156-4172. doi: 10.1126/science.abf8424.
Costanzo M, Hou J, Messier V, Nelson J, Rahman M, VanderSluis B, Wang W, Pons V, Ross C, Ušaj M, San Luis BJ, Shuteriqi E, Koch EN, Aloy P, Myers CL, Boone C, Andrews B.
Environmental robustness of the global yeast genetic interaction network. Science. 2021 372(6542):eabf8424. doi: 10.1021/acs.jcim.0c00993.
Arita Y, Kim G, Li Z, Friesen H, Turco G, Wang RY, Climie D, Usaj M, Hotz M, Stoops EH, Baryshnikova A, Boone C, Botstein D, Andrews BJ, McIsaac RS.
A genome-scale yeast library with inducibleexpression of individual genes. Mol Syst Biol. 2021 17:e10207. doi: 10.15252/msb.202110207.
2020
Kintaka R, Makanae K, Namba S, Kato H, Kito K, Ohnuki S, Ohya Y, Andrews BJ, Boone C, Moriya H.
Genetic profiling of protein burden and nuclear export overload. Elife. 2020 4;9:e54080. doi: 10.7554/eLife.54080.
Mattiazzi Usaj M, Sahin N, Friesen H, Pons C, Usaj M, Masinas MPD, Shuteriqi E, Shkurin A, Aloy P, Morris Q, Boone C, Andrews BJ.
Systematic genetics and single-cell imaging reveal widespread morphological pleiotropy and cell-to-cell variability. Mol Syst Biol. 2020 16(2):e9243. doi: 10.15252/msb.20199243.
2019
Zhou FL, Li SC, Zhu Y, Guo WJ, Shao LJ, Nelson J, Simpkins S, Yang DH, Liu Q, Yashiroda Y, Xu JB, Fan YY, Yue JM, Yoshida M, Xia T, Myers CL, Boone C, Wang MW.
Integrating yeast chemical genomics and mammalian cell pathway analysis. Acta Pharmacol Sin. 2019 May 28. doi: 10.1038/s41401-019-0231-y.
Simpkins SW, Deshpande R, Nelson J, Li SC, Piotrowski JS, Ward HN, Yashiroda Y, Osada H, Yoshida M, Boone C, Myers CL.
Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments. Nat Protoc. 2019 14(2):415-440. doi: 10.1038/s41596-018-0099-1.
2018
Simpkins SW, Nelson J, Deshpande R, Li SC, Piotrowski JS, Wilson EH, Gebre AA, Safizadeh H, Okamoto R, Yoshimura M, Costanzo M, Yashiroda Y, Ohya Y, Osada H, Yoshida M, Boone C, Myers CL.
Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions. PLoS Comput Biol. 2018 14(10):e1006532. doi: 10.1371/journal.pcbi.1006532.
Nelson J, Simpkins SW, Safizadeh H, Li SC, Piotrowski JS, Hirano H, Yashiroda Y, Osada H, Yoshida M, Boone C, Myers CL.
MOSAIC: a chemical-genetic interaction data repository and web resource for exploring chemical modes of action. Bioinformatics. 2018 34(7):1251-1252. doi: 10.1093/bioinformatics/btx732.
2017
Piotrowski JS, Li SC, Deshpande R, Simpkins SW, Nelson J, Yashiroda Y, Barber JM, Safizadeh H, Wilson E, Okada H, Gebre AA, Kubo K, Torres NP, LeBlanc MA, Andrusiak K, Okamoto R, Yoshimura M, van Leeuwen J, Shirahige K, Baryshnikova A, Brown GW, Hirano H, Costanzo M, Andrews B, Ohya Y, Osada H, Yoshida M, Myers CL, Boone C.
Functional Annotation of Chemical Libraries across Diverse Biological Processes. Nat Chem Biol. 2017 13(9):982-993.
Sideri T, Yashiroda Y, Ellis DA, Rodríguez-López M, Yoshida M, Tuite MF, Bähler J.
The copper transport-associated protein Ctr4 can form prion-like epigenetic determinants in Schizosaccharomyces pombe. Microb Cell. 2017 4(1):16-28.
Li G, Poulsen M, Fenyvuesvolgyi C, Yashiroda Y, Yoshida M, Simard JM, Gallo RC, Zhao RY.
Characterization of cytopathic factors through genome-wide analysis of the Zika viral proteins in fission yeast. Proc Natl Acad Sci U S A. 2017 114(3):E376-E385.
2016
Costanzo M, VanderSluis B, Koch EN, Baryshnikova A, Pons C, Tan G, Wang W, Usaj M, Hanchard J, Lee SD, Pelechano V, Styles EB, Billmann M, van Leeuwen J, van Dyk N, Lin ZY, Kuzmin E, Nelson J, Piotrowski JS, Srikumar T, Bahr S, Chen Y, Deshpande R, Kurat CF, Li SC, Li Z, Usaj MM, Okada H, Pascoe N, San Luis BJ, Sharifpoor S, Shuteriqi E, Simpkins SW, Snider J, Suresh HG, Tan Y, Zhu H, Malod-Dognin N, Janjic V, Przulj N, Troyanskaya OG, Stagljar I, Xia T, Ohya Y, Gingras AC, Raught B, Boutros M, Steinmetz LM, Moore CL, Rosebrock AP, Caudy AA, Myers CL, Andrews B, Boone C.
A global genetic interaction network maps a wiring diagram of cellular function. Science. 2016 353(6306). pii: aaf1420.
Sun X, Hirai G, Ueki M, Hirota H, Wang Q, Hongo Y, Nakamura T, Hitora Y, Takahashi H, Sodeoka M, Osada H, Hamamoto M, Yoshida M, Yashiroda Y.
Identification of novel secreted fatty acids that regulate nitrogen catabolite repression in fission yeast. Sci Rep. 2016 6:20856.
Dickinson Q, Bottoms S, Hinchman L, McIlwain S, Li S, Myers CL, Boone C, Coon JJ, Hebert A, Sato TK, Landick R, Piotrowski JS.
Mechanism of imidazolium ionic liquids toxicity in Saccharomyces cerevisiae and rational engineering of a tolerant, xylose-fermenting strain. Microb Cell Fact. 2016 15:17.
2015
Serate J, Xie D, Pohlmann E, Donald C Jr, Shabani M, Hinchman L, Higbee A, Mcgee M, La Reau A, Klinger GE, Li S, Myers CL, Boone C, Bates DM, Cavalier D, Eilert D, Oates LG, Sanford G, Sato TK, Dale B, Landick R, Piotrowski J, Ong RG, Zhang Y.
Controlling microbial contamination during hydrolysis of AFEX-pretreated corn stover and switchgrass: effects on hydrolysate composition, microbial response and fermentation. Biotechnol Biofuels. 2015 8:180.
Piotrowski JS, Okada H, Lu F, Li SC, Hinchman L, Ranjan A, Smith DL, Higbee AJ, Ulbrich A, Coon JJ, Deshpande R, Bukhman YV, McIlwain S, Ong IM, Myers CL, Boone C, Landick R, Ralph J, Kabbage M, Ohya Y.
Plant-derived antifungal agent poacic acid targets β-1,3-glucan. Proc Natl Acad Sci U S A. 2015 112(12):E1490-7.
Fung SY, Sofiyev V, Schneiderman J, Hirschfeld AF, Victor RE, Woods K, Piotrowski JS, Deshpande R, Li SC, de Voogd NJ, Myers CL, Boone C, Andersen RJ, Turvey SE.
Unbiased screening of marine sponge extracts for anti-inflammatory agents combined with chemical genomics identifies girolline as an inhibitor of protein synthesis. ACS Chem Biol. 2014 9(1):247-57. doi: 10.1021/cb400740c. Epub 2013 Oct 29.
2013
Deshpande R, Asiedu MK, Klebig M, Sutor S, Kuzmin E, Nelson J, Piotrowski J, Shin SH, Yoshida M, Costanzo M, Boone C, Wigle DA, Myers CL.
A comparative genomic approach for identifying synthetic lethal interactions in human cancer. Cancer Res. 2013 73(20):6128-36.
Yoshida M, Ohnuki S, Yashiroda Y, Ohya Y.
Profilin is required for Ca2+ homeostasis and Ca2+-modulated bud formation in yeast. Mol Genet Genomics. 2013 288(7-8):317-28.
2012
Takahashi H, Sun X, Hamamoto M, Yashiroda Y, Yoshida M.
The SAGA histone acetyltransferase complex regulates leucine uptake through the Agp3 permease in fission yeast. J Biol Chem. 2012 287(45):38158-67.
Williams DE, Dalisay DS, Patrick BO, Matainaho T, Andrusiak K, Deshpande R, Myers CL, Piotrowski JS, Boone C, Yoshida M, Andersen RJ.
Padanamides A and B, highly modified linear tetrapeptides produced in culture by a Streptomyces sp. isolated from a marine sediment. Org Lett. 2011 13(15):3936-9. doi: 10.1021/ol2014494. Epub 2011 Jul 12.
Arita Y, Nishimura S, Matsuyama A, Yashiroda Y, Usui T, Boone C, Yoshida M.
Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome. Mol. BioSyst. 2011 7(5):1463-72.
Yashiroda Y, Okamoto R, Hatsugai K, Takemoto Y, Goshima N, Saito T, Hamamoto M, Sugimoto Y, Osada H, Seimiya H, Yoshida M.
A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor. Biochem Biophys Res Commun. 2010 394(3):569-73.
Yoshida M, Takeuchi H, Ishida Y, Yashiroda Y, Yoshida M, Takagi M, Shin-ya K, Doi T.
Synthesis, structure determination, and biological evaluation of destruxin E. Org Lett. 2010 12(17):3792-5.
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