Takao Ono, Ph. D.
Education
| 1983-89 | Hirosaki University, Hirosaki, Aomori, Japan. B. S., Biology, 1987 |
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| 1989-95 | Hokkaido University, Sapporo, Japan. Ph. D., Zoology, 1995 |
Research and Professional Experience
| 1995-96 | Lecturer, Department of Medical Technology Hokkaido Prefectural School of Hygiene, Sapporo, Japan. |
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| 1996-02 | Researcher, Department of Genetics, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, Japan. |
| 2002-04 | Visiting Scientist, Cold Spring Harbor Laboratory, U.S.A. |
| 2004-06 | Senior Researcher, Department of Genetics, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, Japan. |
| 2004-06 | Lecturer, School of Nursing, Aichi Prefectural College of Nursing and Health, Nagoya, Aichi, Japan. |
| 2007-present | Senior Research Scientist, RIKEN, Japan. |
Awards and Professional Activities
Professional Activities
| 2007- | Editorial board, Chromosome Science (The Society of Chromosome Research) |
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| 2008 | Member of the committee for The 4th Asian Chromosome Colloquium 2008, Osaka, Japan |
| 2008-10 | Grant-in-Aid for Chromosome Cycle (20055021) |
| 2009 | Member of the committee for The 60th Annual Meeting of the Society of Chromosome Research, Matsue, Shimane, Japan |
Awards
| 2000 | Prize for Poster Presentation from the Japanese Teratology Society |
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| 2005 | Award for Chromosome study from the Society of Chromosome Research |
Academic Society
| 1988- | Member, The Society of Chromosome Research, Japan |
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| 2004- | Member, The Japan Society of Human Genetics |
| 2005- | Member, The Molecular Biology Society of Japan |
Publication List
- Fukuda, K., T. Shimi, C. Shimura, T. Ono, T. Suzuki, K. Onoue, S. Okayama, H. Miura, I. Hiratani, K. Ikeda, Y. Okada, N. Dohmae, S. Yonemura, A. Inoue, H. Kimura and Y. Shinkai. (2023). Epigenetic plasticity safeguards heterochromatin configuration in mammals. Nucleic Acids Res. 51:gkad387.
PMID: 37178005 - Takagi, M., T. Ono, T. Natsume, C. Sakamoto, M. Nakao, N. Saitoh, M. T. Kanemaki, T. Hirano and N. Imamoto. (2018). Ki-67 and condensins support the integrity of mitotic chromosomes through distinct mechanisms. J Cell Sci. 131: jcs212092 doi: 10.1242.
PMID: 29487178 - Ono, T., C. Sakamoto, M. Nakao, N. Saitoh and T. Hirano. (2017). Condensin II plays an essential role in reversible assembly of mitotic chromosomes in situ. Mol Biol Cell. 28:2875-2886.
PMID: 28835373 - Ono, T., D. Yamashita and T. Hirano. (2013). Condensin II initiates sister chromatid resolution during S phase. J Cell Biol. 200:429-441.
PMID: 23401001 - Shiheido, H., Y. Naito, H. Kimura, H. Genma, H. Takashima, T. Ono, T. Hirano, W. Du, T. Yamada, N. Doi, S. Iijima, Y. Hattori and H. Yanagawa. (2012). An anilinoquinazoline derivative inhibits tumor growth through interaction with hCAP-G2, a subunit of condensin II. PLoS One. 7:e44889.
PMID: 23028663 - Yamashita, D., K. Shintomi, T. Ono, I. Gavvovidis, D. Schindler, H. Neitzel, M. Trimborn and T. Hirano. (2011). MCPH1 regulates chromosome condensation and shaping as a composite modulator of condensin II. J Cell Biol. 194:841-854.
PMID: 21911480 - Kamamoto, M., J. Machida, H. Miyachi, T. Ono, A. Nakayama, K. Shimozato and Y. Tokita. (2010). A novel mutation in the C-terminal region of RUNX2/CBFA1 distal to the DNA-binding runt domain in a Japanese patient with cleidocranial dysplasia. Int J Oral Maxillofac Surg. 40:434-437.
PMID: 21115325 - Yamada, K., D. Fukushi, T. Ono, Y. Kondo, R. Kimura, N. Nomura, K.J. Kosaki, Y. Yamada, S. Mizuno and N. Wakamatsu. (2010). Characterization of a de novo balanced t(4;20)(q33;q12) translocation in a patient with mental retardation. Am J Med Genet A. 152A:3057-3067.
PMID: 21086493 - Machida, J., T.M. Felix, J.C. Murray, K. Yoshiura, M. Tanemura, M. Kamamoto, K. Shimozato, S. Sonta and T. Ono. (2009). Searching for genes for cleft lip and/or palate based on breakpoint analysis of a balanced translocation t(9;17)(q32;q12). Cleft Palate Craniofac J. 46:532-540.
PMID: 19929093 - Ono, T., Y. Fang, D.L. Spector and T. Hirano. (2004). Spatial and temporal regulation of condensins I and II in mitotic chromosome assembly in human cells. Mol Biol Cell. 15:3296-3308.
PMID: 15146063 - Ono, T., A. Losada, M. Hirano, M.P. Myers, A.F. Neuwald and T. Hirano T. (2003). Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells. Cell. 115:109-121.
PMID: 14532007 - Wakamatsu, N., Y. Yamada, K. Yamada, T. Ono, N. Nomura, H. Taniguchi, H. Kitoh, N. Mutoh, T. Yamanaka, K. Mushiake, K. Kato, S. Sonta and M. Nagaya. (2001). Mutations in SIP1, encoding Smad interacting protein-1, cause a form of Hirschsprung disease. Nat Genet. 27:369-370.
PMID: 11279515 - Ono, T., Y. Kondoh, N. Kagiyama, S. Sonta and M.C. Yoshida. (2001). Genomic organization and chromosomal distribution of rat ID elements. Genes Genet Syst. 76:213-220.
PMID: 11732629 - Ono, T. and S. Sonta. (2001). Chromosome map of cosmid clones constructed with Chinese hamster genomic DNA. Cytogenet Cell Genet. 95:97-102.
PMID: 11978978 - Rogatcheva, M.B., T. Ono, S. Sonta, S. Oda and P.M. Borodin. (2000). Robertsonian metacentrics of the house musk shrew (Suncus murinus, Insectivora, Soricidae) lose the telomeric sequences in the centromeric area. Genes Genet Syst. 75:155-158.
PMID: 10984840 - Ono, T., S. Hirano, S. Yonezawa, S. Aono, M. Osaki, S. Masaki, S. Yamashita, T. Tsukasaki, A. Oohira A, S.T. Suzuki and S. Sonta. (2000). Comparative mapping of seven genes in mouse, rat and Chinese hamster chromosomes by fluorescence in situ hybridization. Cytogenet Cell Genet. 89:209-213.
PMID: 10965124 - Aono, S., H. Keino, T. Ono, Y. Yasuda, Y. Tokita, F. Matsui, M. Taniguchi, S. Sonta and A. Oohira. (2000). Genomic Organization and Expression Pattern of Mouse Neuroglycan C in the Cerebellar Development. J Biol Chem. 275:337-342.
PMID: 10617623 - Hirano, S., T. Ono, Q. Yan, X. Wang, S. Sonta and S.T. Suzuki. (1999). Protocadherin 2C: a new member of the protocadherin 2 subfamily expressed in a redundant manner with OL-protocadherin in the developing brain. Biochem Biophys Res Comm. 260:641-645.
PMID: 10403819 - Sumiyama, K., K. Washio-Watanabe, T. Ono, M.C. Yoshida, T. Hayakawa and S. Ueda. (1998). Human class III POU genes, POU3F1 and POU3F3, map to chromosome 1p34.1 and 3p14.2. Mamm Genome. 9:180-181.
PMID: 9457692 - Okamoto, T., T. Ono, M. Hori, J.P. Jang, T. Tetsuka, T. Kawabe and S. Sonta. (1998). Assignment of the IkBβgene NFKBIB to human chromosome band 19q13.1 by in situ hybridization. Cytogenet Cell Genet. 82:105-106.
PMID: 9763672 - Yasuda, Y., Y. Tokita, S. Aono, S., F. Matsui, T. Ono, S. Sonta, E. Watanabe, Y. Nakanishi and Oohira, A. (1998). Cloning and chromosomal mapping of the human gene of neuroglycan C (NGC), a neural transmembrane chondrotin sulfate proteoglycan with an EGF module. Neurosci Res. 32:313-322.
PMID: 9950058 - Ono, T. and M.C. Yoshida. (1997). Differences in the chromosomal distribution of telomeric (TTAGGG)n sequences in two species of the vespertilionid bats. Chrom Res. 5:203-212.
PMID: 9246415 - Ono, T., T. Kawabe, S. Sonta and T. Okamoto. (1997). Assignment of MARK3 alias KP78 to human chromosome band 14q32.3 by in situ hybridization. Cytogenet Cell Genet. 79: 101-102.
PMID: 9533022 - Yang, J.P., T. Ono, S. Sonta, T. Kawabe and T. Okamoto. (1997). Assignment of p53 binding protein (TP53BP2) to human chromosome band 1q42.1 by in situ hybridization. Cytogenet Cell Genet. 78:61-62.
PMID: 9345910 - Ono, T., R. Fukumoto, Y. Kondoh and M.C. Yoshida. (1995). Deletion of the Wilson's disease gene in hereditary hepatitis LEC rats. Jpn J Genet. 70:25-33.
PMID: 7772379 - Kondoh, Y., T. Ono, N. Kagiyama, M. Fujita, M. Momiyama, S.H. Hori and M.C. Yoshida. (1995). Simultaneous visualization of Q-bands and FISH signals using a novel fluorochrome. Cytogenet Cell Genet. 71:96-98.
PMID: 7606937 - Ono, T., S. Takada and M.C. Yoshida. (1994). The WD gene for Wilson's disease links to the hepatitis of LEC rats. Jpn J Cancer Res. 85: 771-774.
PMID: 7928621 - Ono, T. and M.C. Yoshida. (1993). Chromosomal assignment of retinoblastoma 1 gene (RB1) to mouse14D3 and rat 15q12 by fluorescence in situ hybridization. Jpn J Genet. 8:617-621.
PMID: 8031579 - Chiba, H., N. Sawada, T. Ono, S. Ishii and M. Mori. (1993). Establishment and characterization of a Simian Virus 40-immortalized osteoblastic cell line from normal human bone. Jpn J Cancer Res. 84:290-297.
PMID: 8387478 - Sone, H., M. Maeda, M. Gotoh, K. Wakabayashi, T. Ono, M.C. Yoshida, N. Takeichi, M. Mori, S. Hirohashi, T. Sugimura and M. Nagao (1992). Genetic linkage between copper accumulation and hepatitis/hepatoma development in LEC rats. Mol Carcinog. 5: 199-204.
PMID: 1316758 - Ono, T., S. Abe and M.C. Yoshida (1991). Hereditary low level of plasma ceruloplasmin in LEC rats associated with spontaneous development of hepatitis and liver cancer. Jpn J Cancer Res. 82:486-489.
PMID: 1905693
