〒351-0198
埼玉県和光市広沢2-1
理化学研究所 開拓研究本部
今本細胞核機能研究室
Tel: 048-467-9749
Fax: 048-462-4716
E-mail: nimamoto _at_ riken. jp

成果発表

2021

  • Kimura, M., Imai, K., Morinaka, Y., Hosono-Sakuma, Y., Horton, P., Imamoto, N. (2021) Distinct mutations in importin-β family nucleocytoplasmic transport receptors transportin-SR and importin-13 affect specific cargo binding. Sci. Rep. 11, 15649. PMID: 34341383

  • Mizuno, T., Hirabayashi, K., Miyazawa, S., Kobayashi, Y., Shoji, K., Kobayashi, M., Hanaoka, F., Imamoto, N., Torigoe, H. (2021) The intrinsically disordered N-terminal region of mouse DNA polymerase alpha mediates its interaction with POT1a/b at telomeres.  Genes Cells  26, 360-380. PMID: 33711210

2020

  • Yamano, S., Kimura, M., Chen, Y., Imamoto, N., Ohki, R. (2020) Nuclear import of IER5 is mediated by a classical bipartite nuclear localization signal and is required for HSF1 full activation. Exp. Cell Res. 386, 111686. PMID: 31669744

2019

  • Imamoto, N., Larson, D. (2019) Editorial overview: Cell nucleus. Curr. Opin. Cell Biol. 58, iii-iv. PMID: 31405511

2018

  • Ogawa, Y., Imamoto, N. (2018) Nuclear transport adapts to varying heat stress in a multistep mechanism. J. Cell Biol. 217, 2341-2352. PMID: 29748335

  • Matsumoto, K., Kose, S., Kuwahara, I., Yoshimura, M., Imamoto, N., Yoshida, M. (2018) Y-box protein-associated acidic protein (YBAP1/C1QBP) affects the localization and cytoplasmic function of YB-1. Sci. Rep. 8, 6198. PMID: 29670170

  • Takagi, M., Ono, T., Natsume, T., Sakamoto, C., Nakao, M., Saitoh, N., Kanemaki, M.T., Hirano, T., Imamoto, N. (2018) Ki-67 and condensins support the integrity of mitotic chromosomes through distinct mechanisms. J. Cell Sci. 131(6). pii: jcs212092. PMID: 29487178

  • Imamoto, N. (2018) Heat stress-induced nuclear transport mediated by HIkeshi confers nuclear function of Hsp70s. Curr. Opin. Cell Biol. 52, 82-87. PMID: 29490261

  • Imamoto, N. (2018) Regulating β-catenin nuclear import with the small GTPase Rap. Developmental Cell 44, 135-136. PMID: 29401416

2017

  • Mimura, Y., Takemoto, S., Tachibana, T., Ogawa, Y., Nishimura, M., Yokota, H., Imamoto, N. (2017) Statistical image analysis framework for pore-free islands derived from heterogeneity distribution of nuclear pore complex. Sci. Rep. 7, 16315. PMID: 29176624 プレスリリース

  • Rahman, K.M.Z., Kose, S., Imamoto, N. (2017) Effect of an inhibitor of HSP70, YM-1 on Hikeshi knockout cells. Thermal Medicine 33, 129-134.

  • Rahman, K.M.Z., Mamada, H., Takagi, M., Kose, S., Imamoto, N. (2017) Hikeshi modulates the proteotoxic stress response in human cells: Implication for the importance of the nuclear function of HSP70s. Genes Cells 22, 968-976. PMID: 28980748

  • Izumi, M., Mizuno, T., Yanagi, K., Sugimura, K., Okumura, K., Imamoto, N., Abe, T., Hanaoka, F. (2017) The Mcm2-7-interacting domain of human mini-chromosome maintenance 10 (Mcm10) protein is important for stable chromatin association and origin firing. J. Biol. Chem. 292, 13008-13021. PMID: 28646110

  • Kimura, M., Morinaka, Y., Imai, K., Kose, S., Horton, P., Imamoto, N. (2017) Extensive cargo identification reveals distinct biological roles of the 12 importin pathways. eLife 2017, 10.7554/eLife.21184. PMID: 28117667 プレスリリース

2016

  • Mimura, Y., Takagi, M., Clever, M., Imamoto, N. (2016) ELYS regulates the localization of LBR by modulating its phosphorylation state. J. Cell Sci. 129, 4200-4212. PMID: 27802161

  • Takagi, M., Natsume, T., Kanemaki, M.T., Imamoto, N. (2016) Perichromosomal protein Ki67 supports mitotic chromosome architecture. Genes Cells 21, 1113-1124. PMID: 27610954
  • Edvardson, S., Kose, S., Jalas, C., Fattal-Valevski, A., Watanabe, A., Ogawa, Y., Mamada, H., Fedick, A.M., Ben-Shachar, S., Treff, N.R., Shaag, A., Bale, S., Gärtner, J., Imamoto, N., Elpeleg, O. (2016) Leukoencephalopathy and early death associated with an Ashkenazi-Jewish founder mutation in the Hikeshi gene. J. Med. Genet. 53, 132-137. PMID: 26545878

2015

  • Mimura, Y., Imamoto, N. (2015). Nuclear Organization (Nuclear Structure and Dynamics). Encyclopaedia of Cell Biology Vol. 2: Organizational Cell Biology, 311-318.

  • Shrestha, R., Tatsukawa, H., Shrestha, R., Ishibashi, N., Matsuura, T., Kagechika, H., Kose, S., Hitomi, K., Imamoto, N., Kojima, S. (2015). Molecular mechanism by which acyclic retinoid induces nuclear localization of transglutaminase 2 in human hepatocellular carcinoma cells. Cell Death Dis. 6:e2002. PMID: 26633708

  • Miyake, N., Tsukaguchi, H., Koshimizu, E., Shono, A., Matsunaga, S., Shiina, M., Mimura, Y., Imamura, S., Hirose, T., Okudela, K., Nozu, K., Akioka, Y., Hattori, M., Yoshikawa, N., Kitamura, A., Cheong, H-I., Kagami, S., Yamashita, M., Fujita, A., Miyatake, S., Tsurusaki, Y., Nakashima, M., Saitsu, H., Ohashi, K., Imamoto, N., Ryo, A., Ogata, K., Iijima, K., Matsumoto, N. (2015). Biallelic Mutations in Nuclear Pore Complex Subunit NUP107 Cause Early-Childhood-Onset Steroid-Resistant Nephrotic Syndrome. Am. J. Hum. Genet. 97, 555-566. PMID: 26411495

  • Song, J., Kose, S., Watanabe, A., Son, S.Y., Choi, S., Hong, H., Yamashita, E., Park, I.Y., Imamoto, N., Lee, S.J. (2015). Structural and functional analysis of Hikeshi, a new nuclear transport receptor of Hsp70s. Acta Crystallogr. D Biol. Crystallogr. 71, 473-483. PMID: 25760597

  • Kose, S., Funakoshi, T., Imamoto, N. (2015). Reconstitution of nucleocytoplasmic transport using digitonin-permeabilized cells. Methods Mol. Biol. 1262, 291-303. PMID: 25555589

2014

  • Song, C., Takagi, M., Park, J.,Xu, R., Gallagher-Jones, M., Imamoto, N., Ishikawa T. (2014). Analytic 3D imaging of mammalian nucleus at nanoscale using coherent X-Rays and optical fluorescence microscopy. Biophysical J. 107, 1074-1081. PMID: 25185543
  • Takagi, M., Nishiyama, Y., Taguchi A., Imamoro N. (2014). Ki67 antigen contributes to the timely accumulation of protein phosphatase 1γ on anaphase chromosomes. J. Biol. Chem. 289, 22877-22887. PMID: 25012651
  • Kose, S., Imamoto, N. (2014). Nucleocytoplasmic transport under stress conditions and its role in HSP70 chaperone systems. BBA-General Subjects 1840, 2953-2960. PMID: 24797038
  • Booth, D., Takagi, M., Sanchez-Pulido, L., Petfalski, E., Vargiu, G., Samejima, K., Imamoto, N., Ponting, C.P., Tollervey, D., Earnshaw, W., Vagnarelli, P. (2014). Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery. eLife 3, e01641. PMID: 24867636
  • Oda, Y., Kimura, M., Kose, S., Fasken, M.B., Corbett, A.H., Imamoto, N. (2014). The Schizosaccharomyces pombe Hikeshi/Opi10 protein has similar biochemical functions to its human homolog but acts in different physiological contexts. FEBS Lett. 588, 1899-1905. PMID: 24768994

     

    Kimura, M., Imamoto, N. (2014). Biological significance of the importin-β family-dependent nucleocytoplasmic transport pathways. Traffic 15, 727-748. PMID: 24766099
  • Kimura, M., Thakar, K., Karaca, S., Imamoto, N., Kehlenbach, R. H. (2014). Novel approaches for the identification of nuclear transport receptor substrates. Methods Cell Biol. 122, 353-378. PMID: 24857738

  • Furuta, M., Kose, S., Kehlenbach, R. H., Imamoto, N. (2014). Analysis of nucleocytoplasmic transport in digitonin-permeabilized cells under different cellular conditions. Methods Cell Biol. 122, 331-352. PMID: 24857737

  • Maeshima, K., Funakoshi, T., Imamoto, N. (2014). Cell-fusion method to visualize interphase nuclear pore (NPC) formation. Methods Cell Biol. 122, 239-254. PMID: 24857733

  • Takagi, M., Imamoto, N. (2014). Control of nuclear size by NPC proteins. Cancer biology and nuclear envelope. Adv. Exp. Med. Biol. 773, 571-591. PMID: 24563366

  • Mäckel, V., Meissl, W., Ikeda, T., Clever, M., Meissl, E., Kobayashi, T., Kojima, T.M., Imamoto, N., Ogiwara, K., Yamazaki, Y. (2014). A novel facility for 3-D micro-irradiation of living cells in a controlled environment by MeV ions. Review of Scientific Instruments 85, 01430. PMID: 24517788

2013

  • Kimura, M., Okumura, N., Kose, S., Takao, T., Imamoto, N. (2013). Identification of cargo proteins specific for importin-β with importin-α applying a stable isotope labeling by amino acids in cell culture (SILAC)-based in vitro transport system. J. Biol. Chem. 288, 24540-24549. PMID: 23846694

  • Imamoto, N. (2013). Cargo recognition explains nuclear transport regulation induced by nuclear pore complex reorganization. J. Mol. Biol. 425, 1849-1851. PMID: 23542339
  • Chinen, T., Kazami, S., Nagumo, Y., Hayakawa, I., Ikedo, A., Takagi, M., Yokosuka, A., Imamoto, N., Mimaki, Y., Kigoshi, H., Osada, H., Usui, T. (2013). Glaziovianin A prevents endosome maturation via inhibiting microtubule dynamics. ACS Chem. Biol. 8, 884-889. PMID: 23406355
  • Clever, M., Mimura, Y., Funakoshi, T., Imamoto, N. (2013). Regulation and coordination of nuclear envelope and nuclear pore complex assembly. Nucleus 4, 105-114. PMID: 23412657
  • Kimura, M., Kose, S., Okumura, N., Imai, K., Furuta, M., Sakiyama, N., Tomii, K., Horton, P., Takao, T., Imamoto, N. (2013). Identification of cargo proteins specific for the nucleocytoplasmic transport carrier transportin by combination of an in vitro transport system and stable isotope labeling by amino acids in cell culture (SILAC)-based quantitative proteomics. Mol. Cell. Proteomics 12, 145-157. PMID: 23087160

2012

  • Hihara, S., Pack, C.G., Kaizu, K., Tani, T., Hanafusa, T., Nozak,i T., Takemoto, S., Yoshimi, T., Yokota, H., Imamoto, N., Sako, Y., Kinjo, M., Takahashi, K., Nagai, T., Maeshima, K. (2012). Local nucleosome dynamics facilitate chromatin accessibility in living Mammalian cells. Cell Rep. 2, 1645-1656. PMID: 23246002
  • Imamoto, N., Kose, S. (2012). Heat-shock stress activates a novel nuclear import pathway mediated by Hikeshi. Nucleus 3, 422-428. PMID: 22895094
  • Imamoto, N., Funakoshi, T. (2012). Nuclear pore dynamics during the cell cycle. Curr. Opin. Cell Biol., 24, 453-459. PMID: 22770730
  • Kose, S., Furuta, M., Imamoto, N. (2012). Hikeshi, a nuclear import carrier for Hsp70s, protects cells from heat-shock induced nuclear damage. Cell 149, 578-589. PMID: 22541429 selected as Faculty of 1000
  • Clever, T., Funakoshi, T., Mimura, Y., Takagi M., Imamoto, N. (2012). The nucleoporin ELYS/Mel28 regulates nuclear envelope subdomain formation in HeLa cells. Nucleus 3:2, 1-13. PMID: 22555603
  • Nishino, Y., Eltsov, M., Joti, Y., Ito K., Takata, H., Takahashi, Y., Hihara, S., Frangakis, A.S., Imamoto, N., Ishikawa, T., Maeshima, K. (2012). Human mitotic chromosomes consist predominantly of irregularly folded nucleosome fibres without a 30-nm chromatin structure. EMBO J. 17, 1644-1653. PMID: 22343941

2011

  • Ikeda, T., Kanai, Y., Iwai, Y., Kojima, T.M., Maeshima, K., Meissl, W., Kobayashi, T., Nebiki, T., Miyamoto, S., Pokhil, G.P., Narusawa, T., Imamoto, N., Yamazaki, Y. (2011). Glass capillary optics for producing nanometer sized beams and its applications. Surface and Coatings Technology 206, 859 – 863.

  • Maeshima, K., Iino, H., Hihara, S., Imamoto, N. (2011). Nuclear size, nuclear pore number, and cell cycle. Nucleus 2:2, 113-118. PMID: 21738834
  • Funakoshi, T., Clever, M., Watanabe, A., Imamoto, N. (2011). Localization of Pom121 to the inner nuclear membrane is required for an early step of interphase nuclear pore complex assembly. Mol. Biol. Cell 22, 1058-1069. PMID: 21289085

2010

  • Maeshima, K., Iino, H., Hihara, S., Funakoshi, T., Watanabe, A., Nishimura, M., Nakatomi, R., Yahata, K., Imamoto, F., Hashikawa, T., Yokota, H., Imamoto, N. (2010). Nuclear pore formation but not nuclear growth is governed by cyclin-dependent kinases (Cdks) during interphase. Nat. Struct. Mol. Biol. 17, 1065-1071. Cover PMID: 20711190
  • Iino, H., Maeshima, K., Nakatomi, R., Kose, S., Hashikawa, T., Tachibana, T., Imamoto, N. (2010). Live imaging system for visualizing nuclear pore complex (NPC) formation during interphase in mammalian cells. Genes Cells 15, 647-60. PMID: 20465562
  • Kosako, H., and Imamoto N. (2010). Phosphorylation of nucleoporins: Signal transduction-mediated regulation of their interaction with nuclear transport receptors. Nucleus 1:4, 1-5. invited review

2009

  • Takemoto, A., Maeshima, K., Ikehara, T., Yamaguchi, K., Murayama, A., Imamura, S., Imamoto, N., Yokoyama, S., Hirano, T., Watanabe, Y., Hanaoka, F., Yanagisawa, J., and Kimura, K. (2009). The chromosomal association of condensin II is regulated by a non-catalytic action of PP2A. Nat. Struct. Mol. Biol. 16, 1302-1308. PMID: 19915589
  • Vanneste, D., Takagi, M., Imamoto, N., and Vernos, I. (2009). The role of Hklp2 in the stabilization and maintenance of spindle bipolarity. Curr. Biol. 19, 1712-1717. PMID: 19767751
  • Kosako, H., Yamaguchi, N., Aranami, C., Ushiyama, M., Kose, S., Imamoto, N., Taniguch, H., Nishida, E., and Hattor, S. (2009). Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin-mediated nuclear transport. Nat. Struct. Mol. Biol. 16, 1026-35. PMID: 19767751
  • Eichinger, C.S., Mizuno, T., Mizuno, K., Miyake, Y., Yanagi, K., Imamoto, N., Hanaoka, F. (2009). Aberrant DNA polymerase alpha is excluded from the nucleus by defective import and degradation in the nucleus. J. Biol. Chem. 284, 30604-14. PMID: 19726690
  • Suzuki, H., Forrest, A.R., van …….Imamoto, N., ……Hayashizaki, Y. (2009). The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nat. Genet. 41, 553-62. PMID: 19377474
  • Nishino, Y., Takahashi, Y., Imamoto, N., Ishikawa, T., and Maeshima, K. (2009). Three-dimensional visualization of a human chromosome using coherent x-ray diffraction, Phys. Rev. Lett. 102, 018101-1-018101-4. Cover PMID: 19257243
  • Watanabe, N., Sekine, T., Takagi, M., Iwasaki, J., Imamoto, N., Kawasaki, H., and Osada, H. (2009). Deficiency in chromosome congression by the inhibition of Plk1 polo box domain-dependent recognition,J. Biol. Chem. 284, 2344-2353. PMID: 19033445

2008

  • Tahara, K,, Takagi, M., Ohsugi, M., Sone,T., Maeshima, K., Horiuchi,Y., Tokai-Nishizumi, N., Fumiko Nishiumi, F., Imamoto, F., Yamamoto, T., Kose, S. and Imamoto, N. (2008). Importin β and small GTPase Ran mediates the chromosome loading of human chromokinesin KID. J. Cell Biol. 180, 493-506. PMID: 18268099
  • Tokunaga, M., Imamoto N., and Sakata-Sogawa, K. (2008). Highly inclined thin illumination enables clear single-molecule imaging in cells. Nat. Methods 5, 159-161. PMID: 18176568
  • Takagi, M., Bunai, K., Yanagi, K., and Imamoto, N. (2008). Cloning of Xenopus orthologs of Ctf7/Eco1 acetyltransferase and initial characterization of XEco2. FEBS J. 275, 6109-6122.PMID: 19016859
  • Hatakeyama M., Tomizawa, T., Sakai-Kato, K., Bouvagnet, P., Kose, S., Imamoto, N., Yokoyama, S., Itsunomita-Tate, N., Mikoshiba, K., Kigawa, T., Aruga, J. (2008). Functional and structural basis of the nuclear localization signal in the ZIC3 zinc finger domain. Hum. Mol. Genet. 17, 3459-3473. PMID: 18716025
  • Kuriyama I., Mizuno T., Fukudome K., Kuramochi K., Tsubaki K., Usui T., Imamoto N., Sakaguchi K., Sugawara F., Yoshida H., and Mizushina Y. (2008). Effect of Dehydroaltenusin-C12 Derivative, a Selective DNA Polymerase Inhibitor, on DNA Replication in Cultured Cells. Molecules 13, 2948-2961. PMID: 19043348
  • Iwai, Y., Maeshima, K., Ikeda, T., Kojima, T.-M., Kobayashi, T.,Nebiki, T., Narusawa, T., Pokhil., G.-P., Imamoto, N., and Yamazaki, Y (2008). Ion irradiation in liquid of μm3 region for cell surgery. Applied Physics Letters 92, 023509-1-023509-3.
  • Wendt, K.S., Yoshida, K., Itoh, T., Bando, M., Koch, B., Schirghuber, E., Tsutsumi, S., Nagae, G., Ishihara, Ko., Mishiro, T., Yahata, K., Imamoto, F., Aburatani, H., Nakao, M., Imamoto, N., Maeshima, K., Shirahige, K., and Peters, J.-M. (2008). Cohesin is required for the transcriptional insulator function of CTCF binding sites. Nature 451, 796-801. PMID: 18235444

2007

  • Yahata, K., Maeshima, K., Sone, T., Ando, T., Okabe, M., Imamoto, N., and Imamoto, F. (2007). cHS4 insulator-mediated alleviation of promoter interference during cell based expression of tandemly associated transgense. J. Mol. Biol. 374, 580-590. PMID: 17945255
  • Funakoshi, T., Maeshima, K., Yahata, K., Imamoto, F., Sugano, S., and Imamoto, N. (2007). Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes. FEBS Lett. 581, 4910-4916. PMID: 17900573
  • Imasaki, T., Shimizu, T., Hashimoto, H., Hidaka, Y., Kose, S., Imamoto, N., Yamada, M., and Sato, M. (2007). Structural basis for substrate recognition and dissociation by human transportin 1. Mol. Cell 28, 57-67. PMID: 17936704
  • Mizushina, Y., Takeuchi, T., Takakusaki, Y., Yonezawa, Y., Mizuno., T., Yanagi, K., Imamoto, N., Sugawara, F., Sakaguchi, K., Yoshida, H., and Fujita, M. (2007). Coenzyme Q(10) as a potent compound that inhibits Cdt1-geminin interaction. Biochim. Biophys. Acta. 1780, 203-213. PMID: 18029098

2006

  • Tanaka, K., Ogawa, K., Takagi, M., Imamoto, N., Matsumoto, K. and Tsujimoto, M. (2006). Rap55, a cytoplasmic mRNP component, represses translation in Xenopus Oocytes. J. Biol. Chem. 281, 40096-40106. PMID: 17074753
  • Maeshima, K., Yahata, K., Sasaki, Y., Nakatomi, R., Tachibana, T., Hashikawa, T., Imamoto,, F., and Imamoto, N. (2006). Cell cycle-dependent dynamics of nuclear pores: pore-free islands and lamins. J. Cell Sci. 119, 4442-4451. Selected as faculty of 1000 PMID: 17074834
  • Handa, N., Kukimoto-Niino, M., Akasaka, R., Kishishita, S., Murayama, K., Terada, T., Inoue, M,. Kigawa, T., Kose, S., Imamoto, N., Tanaka, A., Hayashizaki, Y., Shirouzu, M., and Yokoyama, S. (2006).The crystal structure of mouse Nup35 reveals atypical RNP motifs and novel homodimerization of the RRM domain. J. Mol. Biol. 363, 114-124. PMID: 16962612
  • Aratani, S., Oishi, T., Fujita, H., Nikazawa, M., Fujii, R., Imamoto, N., Yoneda, Y., Fukamizu, A., and Nakajima, T. (2006). The nuclear import of RNA helicase A is mediated by importin-α3. Biochem. Biophys. Res. Commun. 340, 125-133. PMID: 16375861

2005

  • Kose, S., Furuta, M., Koike, M., Yoneda,Y. and Imamoto, N. (2005). The 70-kD heat shock cognate protein (hsc70) facilitates the nuclear export of the import receptors. J. Cell Biol. 171, 19-25. PMID: 16203861
  • Okada, Y., Suzuki, T., Sunden, Y., Ohba,Y., Kose, S., Imamoto, N., Takahashi, H., Tanaka, S., Hall, W.W., Nagashima, K., and Sawa,H. (2005). Dissociation of heterochromatin protein 1 from lamin B receptor induced by human polyomavirus agnoprotein: role nuclear egress of viral particles. EMBO Rep. 6, 452-457. PMID: 15864296

2004

  • Kamikubo,Y., Sakaguchi, Y., Shikata, K., Furuta, M., Miyamoto, Y., Imamoto, N., Yoneda, Y. Ogino,K., and Tachibana, T. (2004). Specific monoclonal antibody against nuclear import factor, importin α1/Rch1. Hybrid. Hybridomics 23, 301-304. PMID: 15672608
  • Koike, M., Kose, S., Furuta, M., Taniguchi, N., Yokota, F., Yoneda, Y. and Imamoto, N. (2004). β-Catenin shows an overlapping sequence requirement but distinct molecular interaction for its bidrectional passage through nuclear pores. J. Biol. Chem. 279, 34038-34047. PMID: 15173161
  • Furuta M., Kose S., Koike M., Shimi T, Hiraoka Y, Yoneda Y, Haraguchi, T., and Imamoto, N. (2004). Heat-shock induced nuclear retention and recycling inhibition of importinα. Genes Cells 9, 429-441. Cover PMID: 15147272

2003

  • Lee, S.J., Sekimoto, T., Yamashita, E., Nagoshi, E., Nakagawa, A., Imamoto, N., Yoshimura, M., Sakai, H., Chong, K.T., Tsukihara, T., and Yoneda, Y. (2003). The structure of importin-β bound to SREBP-2: Nuclear import of a transcription factor. Science 302, 1571-1575.PMID: 14645851

2002以前

  • Jiang,C-J, Shoji, K., Matsuki, R., Baba, A., Inagaki, N., Ban, H., Iwasaki, T., Imamoto, N., Yoneda, Y., Deng, X-Y. and Yamamoto, N. (2001). Molecular cloning of a novel importin αhomologue from Rice, by which constitutive photomorphogenic 1 (COP1) nuclear localization signal (NLS)-protein is preferentially nuclear imported. J. Biol. Chem. 276, 9322-9329. PMID: 11124253
  • Imamoto, N. (2000). Diversity in nucleocytoplasmic transport pathways. Cell Structure and Function 25, 207-216. Review PMID: 11051838
  • Lee, S-J*, Imamoto,N.*, Sakai, H.*, Nakagawa, A., Kose, S., Koike, M., Yamamoto, M., Kumasaka, Y., Yoneda, Y. and Tsukihara, T. 264 (2000). The adoption of a twisted structure of importin-β is essential for the protein-protein interaction required for nuclear transport . J. Mol. Biol. 302, 251-264. * equally contributed PMID: 10964573
  • Tachibana,T., Hieda, M., Miyamoto, Y., Kose, S., Imamoto, N. and Yoneda, Y. (2000). Recycling of importin α from the nucleus is suppressed by loss of RCC1 function in living mammalian cells. Cell Structure and Function 25, 115-123 PMID: 10885581
  • Matsubae, M., Kurihara, T., Tachibana,T., Imamoto, N. and Yoneda, Y. (2000). Characterization of the nuclear transport of a novel leucine-rich acidic nuclear protein-like protein. FEBS Lett., 468, 171-175.PMID: 10692581
  • Haraguchi, T,. Koujin, T., Kaneda, T., Tsutumi, C., Imamoto, N., Akazawa, C., Sukegawa, J., Yoneda, Y. and Hiraoka, Y. (2000). Reformation of the functional nuclear envelope during telophase: Temporal sequences determined by fluorescence imaging in living HeLa cells. J. Cell Sci. 113, 779-794.PMID: 10671368
  • Kose, S., Imamoto, N., and Yoneda, Y.(1999). Distinct energy requirement for nuclear import and export of importin β in living cells. FEBS Lett. 463, 327-330 PMID: 10606747
  • Ohshima,T., Nakajima, T., Oishi, T., Imamoto, N., Yoneda, Y., Fukamizu, A., Yagami, K. (1999). CRM1 mediates nuclear export of nonstructural protein 2 from parvovirus minute virus of mice. Biochem. Biophys. Res. Commun. 264, 144-150.PMID: 10527855
  • Sahara, S., Aoto, M., Eguchi, Y., Imamoto,N., Yoneda, Y. and Tsujimoto, Y. (1999). Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation. Nature 401, 168-173. PMID: 10490026
  • Nagoshi, E., Imamoto, N., Sato, R. and Yoned, Y. (1999). Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin β with HLH-Zip. Mol. Biol. Cell 10, 2221-2233. PMID: 10397761
  • Yokoya, F.*, Imamoto,N*, Tachibana, T. and Yoneda, Y. (1999). β-Catenin can be transported into the nucleus in a Ran-unassisted manner. Mol. Biol. Cell 10, 1119-1131. *equally constributed PMID: 10198061
  • Hieda, M., Tachibana, T., Yokoya, F., Kose, S., Imamoto, N. and Yoneda, Y. (1999). A monoclonal antibody to the COOH-terminal acidic portion of Ran inhibits both the recycling of Ran and nuclear protein import in living cells. J. Cell Biol. 144, 645-655. PMID: 10037787
  • Kose, S., Imamoto, N., Tachibana, T., Yoshida, M. and Yoneda, Y. (1999). β-Subunit of nuclear pore-targeting complex (Importin-β) can be exported from the nucleus in a Ran-independent manner. J. Biol. Chem. 274, 3946-3952. PMID: 9933584
  • Imamoto, N., Miyamoto, Y. and Yoneda, Y. (1998). Import and export of proteins at the nucleus. Membrane Protein Insertion and Translocation (Portland Press, UK), Review
  • Yamada, M., Tachibana, T., Imamoto, N. and Yoneda, Y. (1998). Nuclear transport factor p10/NTF2 functions as a Ran-GDP dissociation inhibitor (Ran-GDI). Curr. Biol. 8, 1339-1342.PMID: 9843686
  • Matsusaka, T., Imamoto, N., Yoneda, Y. and Yanagida, M. (1998). Mutations in fission yeast Cut15, an importin α homologue, lead to mitotic progression without chromosome condensation. Curr. Biol. 8, 1031-1034. PMID: 9740803
  • Jiang, C-J., Imamoto, N. Matsuki, R., Yoneda, Y. and Yamamoto, N. (1998). In vitro characterization of rice importin β-1: Molecular interaction with nuclear transport factors and mediation of nuclear protein import. FEBS Lett. 437, 127-130. PMID: 9804185
  • Jiang, C-J., Imamoto, N., Matsuki, R., Yoneda, Y. and Yamamoto, N. (1998). Functional characterization of a plant importin α homologue: Nuclear localization signal (NLS)-selective binding and mediation of nuclear import of NLS-proteins in vitro. J. Biol. Chem. 273, 24083-24087. PMID: 9727027
  • Imamoto, N, Kamei, Y. and Yoneda, Y. (1998). Nuclear transport factors:Function, behavior and interaction. Eur. J. Histochem. 42, 9-20 . Review PMID: 9615187
  • Kose, S.*, Imamoto, N.*, Tachibana, T., Shimamot, T. and Yoneda, Y. (1997). Ran-unassisted nuclear migration of a 97kDa component of nuclear pore-targeting complex. J. Cell Biol. 139, 841-849. * equally construbuted PMID: 9362503
  • Sekimoto, T. Imamoto, N., Nakajima, K., Hirano, T. and Yoneda, Y. (1997). Extracellular signal-dependent nuclear import of Stat1 is mediated by nuclear pore-targeting complex formation with NPI-1, but not Rch1. EMBO J. 16, 7067-7077. PMID: 9384585
  • Miyamoto, Y., Imamoto, N., Sekimoto, T., Tachibana, T., Seki, T., Tada, S., Enomoto, T. and Yoneda, Y.(1997). Differential modes of nuclear localization signal (NLS) recognition by three distinct classes of NLS receptors. J. Biol. Chem. 272, 26375-26381. PMID: 9334211
  • Tsuji, L., Takumi, T., Imamoto, N. and Yoneda, Y. (1997). Identification of novel homologues of mouse importin α, the α subunit of the nuclear pore-targeting complex, and their tissue specific expression. FEBS Lett. 416, 30-34. PMID: 9369227
  • Yasuhara, N., Eguchi, Y., Tachibana, T., Imamoto, N., Yoneda, Y. and Tsujimoto, Y. (1997). Essential roles of active nuclear transport in apoptosis. Genes Cells 2, 55-64. PMID: 9112440
  • Imamoto, N., Shimamoto, T., Takao, T., Tachibana, T., Kose, S., Matsubae, M., Sekimoto, T., Shimonishi, Y. and Yoneda, Y. (1995). In vivo evidence for involvement of a 58kDa component of nuclear pore-targeting complex in nuclear protein import. EMBO J. 14, 3617-3626. PMID: 7641681
  • Imamoto, N.*, Shimamoto, T.*, Kose, S., Takao, T., Tachibana, T., Matsubae, M., Sekimoto, T., Shimonishi, Y. and Yoneda, Y. (1995). The nuclear pore-targeting complex binds to nuclear pores after association with a karyophile. FEBS Lett. 368,415-419. *equally contributed PMID: 7635189
  • Imamoto, N., Tachibana, T., Matsubae, M. and Yoneda, Y. (1995). A karyophilic protein forms a stable complex with cytoplasmic components prior to nuclear pore binding. J. Biol. Chem. 270, 8559-8565. PMID: 7721756
  • Terada, K., Ohtsuka, K., Imamoto, N., Yoneda, Y. and Mori, M. (1995). Role of heat shock cognate protein in import of ornithine transcarbamylase precursor into mammalian mitochondria. Mol. Cell. Biol. 15, 3708-3713. PMID: 7791777
  • Tachibana, T., Imamoto, N., Seino,H., Nishimoto, T. and Yoneda, Y. (1994). Loss of RCC1 leads to suppression of nuclear protein import in living cells. J. Biol. Chem. 269, 24542-24545. PMID: 7929123
  • Okuno, Y., Imamoto, N. and Yoneda, Y. (1993). 70-kDa heat-shock cognate protein colocalizes with karyophilic proteins into the nucleus during their transport in vitro. Exp. Cell Res. 206, 134-142. PMID: 8482354
  • Imamoto, N., Matsuoka, Y., Kurihara, T., Kohno, K., Miyagi, M., Sakiyama, F., Okada, Y., Tsunasawa, S. and Yoneda, Y. (1992). Antibodies against 70-kD heat shock cognate protein inhibit nuclear import of karyophilic proteins. J. Cell Biol. 119, 1047-1061. PMID: 1332978
  • Yoneda, Y., Semba, T., Kaneda, Y., Noble,R-L., Matsuoka, Y., Kurihara, T., Okada, Y. and Imamoto, N. (1992). A long synthetic peptide containing a nuclear localization signal and its flanking sequences of SV40 T-antigen directs the transport of IgM into the nucleus efficiently. Exp. Cell Res. 201, 313-320. PMID: 1322314
  • Imamoto, N., Matsuoka, Y., Semba, T., Okada, Y., Uchida, T. and Yoneda, Y.(1990). A protein recognized by antibodies to Asp-Asp-Asp-Glu-Asp shows specific binding activity to heterogeneous nuclear transport signals. J. Biol. Chem. 265, 16504-16508. PMID: 2398061
  • Yoneda, Y., Imamoto, N., Matsuoka, Y., Iwamoto, R., Yukio, K. and Uchida, T. (1988). Antibodies to Asp-Asp-Glu-Asp can inhibit transport of nuclear proteins into the nucleus. Science 242, 275-278. PMID: 3051382
  • Imamoto, N., Yoneda, Y., Iwamoto, R., Sugawa, H. and Uchida, T. (1988). ATP-dependent association of nuclear proteins with isolated rat liver nuclei. Proc. Natl. Acad. Sci. USA 85, 3426-3430 PMID: 3368451
  • Yoneda, Y., Imamoto, N., Yamaizumi, M., and Uchida, T. (1987). Reversible Inhibition of protein into the nucleus by wheat germ agglutinin injected into cultured cells. Exp. Cell Res. 173, 586-595. PMID: 2446896
  • Yoneda, Y., Arioka, T., Imamoto, N., Sugawa, H., Shimonishi, Y. and Uchida, T. (1987). Synthetic peptides containing a region of SV40 large T-antigen involved in nuclear localization direct the transport of proteins into the nucleus. Exp. Cell Res. 170, 439-452 . PMID: 3595738
  • Tsuneoka, M., Imamoto, N., and Uchida, T. (1986). Monoclonal antibody against non-histone chromosomal protein high mobility group 1 co- migrates with high mobility group 1 into the nucleus. J. Biol. Chem. 261,1829-1834. PMID: 3944111
  • Sugawa, H., Imamoto, N., Wataya-Kaneda, M. and Uchida, T. (1985). Foreign protein can be carried into the nucleus of mammalian cell by conjugation with nucleoplasmin. Exp. Cell Res. 159, 419-429. PMID: 3896829

和文著書・総説

  • 小瀬真吾、今本尚子 「新しい核-細胞質間運搬体分子 “Hikeshi”の同定:熱ストレス応答時の分子シャペロンHsp70の核内移行とその機能」 実験医学 30 (16) 2621-2624 (2012).
  • 小瀬真吾、今本尚子 「“Hikeshi”は分子シャペロンHsp70を核に輸送し熱ストレスによる核の損傷から細胞を守る」 ライフサイエンス新着論文レビュー 6月12日 (2012).
  • 今本尚子 「核膜と核膜孔複合体の形成機構」 細胞工学 1135-1141 (2011).
  • 今本尚子、三村恭弘、船越智子 「核膜孔複合体の形成機構」 生体の科学 62 378-379 (2011).
  • 船越智子、今本尚子 「Pom121の構造と核膜孔形成における役割」 生体の科学 62 388-389 (2011).
  • 三村恭弘、今本尚子 「Nup107-133 complexがつくる核膜孔複合体の基礎構造」 生体の科学 62 390-391 (2011).
  • 今本尚子 第2章 オルガネラ形成機構の研究法「核膜」 生物薬科学実験講座5 細胞の構造とオルガネラ(2010).
  • 高木昌俊、田原清志、今本尚子 「核と細胞質のあいだの輸送を担う因子の新たな機能—Kidをモデル分子としてみえてきたもの」 蛋白質・核酸・酵素 Vol.53 No.9 1115-1124 (2008).
  • 今本尚子 「核ー細胞質間分子輸送:細胞内1分子イメージング顕微鏡法による観察」 ナノイメージング 255-264 ブッカーズ (2008).
  • 小瀬真吾、今本尚子 「細胞質から核へのタンパク質輸送」 機能性DDSキャリアの製剤設計 第3章 169-176 ㈱シーエムシー出版 (2008).
  • 前島一博、今本尚子 「細胞周期における核膜孔のダイナミクス」 生化学 80巻 第2号 118-124 (2008).
  • 前島一博、矢幡一英、今本文男、今本尚子 「インスレーター/バウンダリー配列を用いた複数の導入遺伝子を安定的に発現させるシステム」 羊土社バイオテクノロジージャーナル 9−10月号 557-563 (2007).
  • 今本尚子 「核膜孔複合体:分子構築と機能」 蛋白質核酸酵素 11月号増刊 細胞核の世界 (2006).
  • 今本尚子 「核膜孔複合体:核-細胞質間分子流通のメディエーターとしての機能と構造」 遺伝子医学MOOK 5号 「先端生物医学研究・医療のための遺伝子導入テクノロジー ウィルスを用いない遺伝子導入法の材料、技術、方法論の新たな展開」 (2006).
  • 今本尚子 「核と細胞質間の分子流通メカニズム」 細胞核の分子生物学ークロマチン・染色体・核構造ー 第6章 155-175 朝倉書店 (2005).
  • 今本文男、曽根岳史、矢幡一英、佐々木ゆかり、高木昌俊、前島一博、今本尚子 「生細胞への複数種cDNAの共導入と発現量の制御」 蛋白質核酸酵素 Vol.50 1637-1648 (2005).
  • 今本尚子、古田満衣子、小池牧子、小瀬真吾 「核膜孔複合体の分子機構とダイナミクス」 細胞核ダイナミクス・フェアラーク東京株式会社 195-201 (2004).
  • 小瀬真吾、今本尚子 「核膜孔複合体と核ー細胞質間輸送」 蛋白質核酸酵素 Vol.49 907-909 (2004).
  • 古田満衣子、小池牧子、小瀬真吾、今本尚子 「核ー細胞質間分子輸送 : 輸送経路の多様性」 実験医学 Vol.21 1961-1967 (2003).
  • 今本尚子 「細胞内輸送研究:細胞と個体形成の秩序を知る」 実験医学 Vol.21 1836-1841 (2003).
  • 今本尚子 「核膜孔複合体:謎の多い核ー細胞質間分子流通の場」 実験医学 Vol.20 No.7 974-979 (2002).
  • 小瀬真吾、今本尚子 「核ー細胞質間タンパク質輸送の基本メカニズム」 実験医学 Vol.20 No.14 2075-2081 (2002).
  • 今本尚子 「核ー細胞間機能分子輸送」 蛋白質核酸酵素 共立出版 Vol.45 No.14 (2000).
  • 今本尚子 「核ー細胞質間分子輸送」 バイオサイエンスの新世紀 共立出版 (2000). 
  • 小瀬真吾、今本尚子 「細胞質から核へのタンパク質輸送の分子メカニズム」 実験医学 Vol.17 No.18 (増刊) 2354-2360 (1999).
  • 横屋史彦、今本尚子 「輸送担体としての性質をもつ-カテニン:核膜孔通過能をもつ分子」 細胞工学(秀潤社) 4月号 475-482 (1999).
  • 今本尚子 「核タンパク質輸送の分子機構」 生化学(日本生化学会誌) 第69巻 383-393 (1997).
  • 今本尚子 「核膜孔ターゲティング複合体/Importin ファミリー」 癌と化学療法(癌と化学療法社) Vol. 24 (1997).
  • 今本尚子 「核膜孔ターゲティング複合体と核蛋白質輸送」 実験医学(羊土社) 第14巻 32-37 (1996).
  • 今本尚子 「核タンパク質輸送と70kDa熱ショックタンパク質」 生体の科学(医学書院) 第46巻 328-332 (1995).
  • 今本尚子、米田悦啓 「核タンパク質輸送の分子メカニズム」 日本農芸化学会誌 第69巻 53-56 (1995).
  • 立花太郎、今本尚子、米田悦啓 「核蛋白質輸送の分子メカニズムとその制御」 実験医学(羊土社) 第13巻 1354-1359 (1995).
  • 今本尚子 「核移行シグナル」 実験医学(羊土社) 第12巻 1671-1673 (1994).
  • 今本尚子 「核タンパク質輸送と熱ショックタンパク質」 細胞工学(秀潤社) 第11巻 179-184 (1992).
  • 今本尚子、河野憲二 「分子シャペロン」 細胞(ニューサイエンス社) 第24巻 294-299 (1992).
  • 今本尚子、米田悦啓 「蛋白質の核へのターゲティングと局在化の分子機構」 実験医学(羊土社) 第9巻 2196-2202 (1991).
  • 今本尚子、米田悦啓 「核タンパク質の核内輸送機構」 BIOmedica 第6巻 413-418 (1991).
  • 今本尚子、内田驍 「核蛋白質の核局在化機構」 生体の科学(医学書院) 第39巻 570-574 (1988).

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