2014年度 - 原著論文

* correspondence

*Stasevich TJ, Hayashi-Takanaka Y, Sato Y, Maehara K, Ohkawa Y, Sakata-Sogawa K, Tokunaga M, Nagase T, Nozaki N, McNally JG, *kimura.
Regulation of RNA polymerase II activation by histone acetylation in single living cells.
Nature.   516: 272-275. 2014.

Forrest AR et al and FANTOM Consortium.
A promoter-level mammalian expression atlas.
Nature  507: 462-470, 2014

Arner E et al and FANTOM Consortium.
Enhancers lead waves of coordinated transcription in transithioning mammalian cells.
Science   2015 in press

Shinagawa T*, Takagi T, Tsukamoto D, Tomaru C, Huynh LM, Sivaraman P, Kumarevel T, Inoue K, Nakato R, Katou Y, Sado T, Takahashi S, Ogura A, Shirahige K, Ishii*.
Histone variants enriched in oocytes enhance reprogramming to induced pluripotent stem cells.
Cell Stem Cell.  14: 217-227,2014.

Itoh-Nakadai A, Hikota R, Muto A, Kometani K, Watanabe-Matsui M, Sato Y, Kobayashi M, Nakamura A, Miura Y, Yano Y, Tashiro S, Sun J, Ikawa T,  Ochiai K, Kurosaki T, *Igarashi K.
The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program.
Nat Immunol.  12:1171-1180, 2014

Boucheron N, Tschismarov R, Goeschl L, Moser M.A, Lagger S, Sakaguchi S, Winter M, Lenz F, Vitko D, Breitwieser FP, M_ller L, Hassan H, Bennett K.L, Colinge J, Schreiner W, Egawa T, Taniuchi I, Matthias P, Seiser C, *Ellmeier W.
CD4+ T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2.
Nat. Immunol. 15:439-48. 2014.

Stinke FC, Yu S, Zhou X, Yang W, Zhou B, Kawamoto H, Zhu J, Tan K, *Xue HH*.
TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4+ T cell fate and interact with Runx3 to silence Cd4 in CD8+ T cells.
Nat. Immunol.  15: 646-656. 2014.

Obata Y, Furusawa Y, Endo TA, Sharif J, Takahashi D, Atarashi K, Nakayama M, Onawa S, Fujimura Y, Takahashi M, Ikawa T, Otsubo T, Kawamura YI, Dohi T, Tajima S, Masumoto H, Ohara O, Honda K, Hori S, Ohno H, Koseki H, *Hase K.
The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells.
Nat. Immunol.  15: 571-579. 2014.

Daussy C, Faure F, Mayol K, Viel S, Gasteiger G, Charrier E, Bienvenu J, Henry T, Debien E, Hasan UA, Marvel J, Yoh K, Takahashi S, Prinz I, De Bernard S, Buffat L, Walzer T*.
T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and bone marrow.
J Exp Med.  211: 563-577,2014.

Moriyama S, Takahashi N, Green JA, Hori S, Kubo M, Cyster JG, *Okada T.
Sphingosine-1-phosphate receptor 2 is critical for follicular helper T cell retention in germinal centers.
J. Exp. Med.  211: 1297-1305. 2014.

Tanaka S, Suto A, Iwamoto T, Kashiwakuma D, Kagami SI, Suzuki K, Takatori H, Tamachi T, Hirose K, Onodera A, Suzuki J, Ohara O, Yamashita M, Nakayama T, *Nakajima H.
Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORγt induction as downstream target of Stat3.
J. Exp. Med.  211: 1857-1874. 2014.

Hao B, Naik AK, Watanabe A, Tanaka H, Chen L, Kondo M, Taniuchi I, Kohwi Y, Kohwi-Shigematus T and *Krangel MS.
An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development.
J.Exp.Med.  in press

Majumder K, Koues O, Chan E, Kyle K, Horowitz J, Yang-Iott K, Bassing C, Taniuchi I, Krangel M, *Oltz E. Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element.
J.Exp.Med.  212:107-20. 2015.

Fujiwara S, Nagai H, Shimoura N, Oniki S, Yoshimoto T, *Nishigori C.
Intratumoral CD4+ T lymphodepletion sensitizes poorly immunogenic melanomas to immunotherapy with an OX40 agonist.
J. Invest. Dermatol.  134: 1884-1892. 2014.

Miyamura S, Araki M, Suzuki T, *Yamaguchi J, *Itami K.
Stereodivergent synthesis of arylcyclopropylamines by sequential C-H borylation and Suzuki-Miyaura coupling.
Angew. Chem. Int. Ed.  54: 846-851. 2015.

Kaneko K, Kamimoto K, Miyajima A and Itoh T*.
Adaptive remodeling of the biliary architecture underlies liver homeostasis.
Hepatology  in press.

Mishima Y, Wang C, Miyagi S, Saraya A, Hosokawa H, Mochizuki-Kashio M, Nakajima-Takagi Y, Koide S, Negishi M, Sashida G, Naito T, Ishikura T, Onodera A, Nakayama T, Tenen D.G, Yamaguchi N, Koseki H, Taniuchi I, *Iwama A.
Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development.
Nat Commun.  5:5872. 2015.

Hamada M*, Nakamura M, Tran MT, Moriguchi T, Hong C, Ohsumi T, Dinh TT, Kusakabe M, Hattori M, Katsumata T, Arai S, Nakashima K, Kudo T, Kuroda E, Wu CH, Kao PH, Sakai M, Shimano H, Miyazaki T, Tontonz P, Takahashi S*.
MafB promotes atherosclerosis by inhibiting foam-cell apoptosis.
Nat Commun.  5: 3147, 2014.

Kuwahara M, Suzuki J, Tofukuji S, Yamada T, Kanoh M, Matsumoto A, Maruyama S, Kometani K, Kurosaki T, Ohara O, Nakayama T, *Yamashita M.
Menin-Bach2 axis is critical for regulating CD4 T cell senescence and cytokine homeostasis.
Nat. Commun.  5: 3555. 2014.

Nakahata S, Ichikawa T, Maneesaay P, Saito Y, Nagai K, Tamura T, Manachai N, Yamakawa N, Hamasaki M, Kitabayashi I, Arai Y, Kanai Y, Taki T, Abe T, Kiyonari H, Shimoda K, Ohshima K, Horii A, Shima H, Taniwaki M, Yamaguchi R, *Morishita K :
Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers.
Nature Comm.  5: 3393. 2014.

Mishima Y, Wang C, Miyagi S, Saraya A, Hosokawa H, Mochizuki-Kashio M, Nakajima-Takagi Y, Koide S, Negishi M, Sashida G, Naito T, Ishikura T, Onodera A, Nakayama T, Tenen DG, Yamaguchi N, Koseki H, Taniuchi I, *Iwama A.
Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development.
Nature Commun.  2014; 5: 5872.

*Sashida G, Harada H, Matsui H, Oshima M, Yui M, Harada Y, Tanaka S, Mochizuki-Kashio M, Wang C, Saraya A, Muto T, Hayashi Y, Suzuki K, Nakajima H, Inaba T, Koseki H, Huang G, Kitamura T, *Iwama A.
Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation.
Nature Commun.  2014; 5: 4177.

Inagaki N, Inagaki F, Kokudo N and Miyajima A*.
Use of mouse liver mesothelial cells to prevent postoperative adhesion and promote liver regeneration after hepatectomy.
J. Hepatology,  in press

Hojyo S, Miyai T, Fujishiro H, Kawamura M, Yasuda T, Hijikata A, Bin BH, Iri_ T, Tanaka J, Atsumi T, Murakami M, Nakayama M, Ohara O, Himeno S, Yoshida H, Koseki H, Ikawa T, Mishima K, *Fukada T.
Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength.
Proc Natl Acad Sci U S A.  111:11786-91, 2014

Miyai T, Hojyo S, Ikawa T, Kawamura M, Iri_ T, Ogura H, Hijikata A, Bin BH, Yasuda T, Kitamura H, Nakayama M, Ohara O, Yoshida H, Koseki H, Mishima K, *Fukada T.
Zinc transporter SLC39A10/ZIP10 facilitates antiapoptotic signaling during early B-cell development.
Proc Natl Acad Sci U S A.   111(32):11780-5, 2014

Obata Y, Furusawa Y, Endo TA, Sharif J, Takahashi D, Atarashi K, Nakayama M, Onawa S, Fujimura Y, Takahashi M, Ikawa T, Otsubo T, Kawamura YI, Dohi, Tajima S, Matsumoto H, Ohara O, Honda K, Hori S, Ohno H, Koseki H, *Hase K.
The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells.
Nat Immunol.  15: 571-579, 2014

Morikawa K, Ohkura N, Vandenbon A, Itoh M, Nagao-Sato S, Kawaji H, Lassmann T, Carninci P, Hayashizaki Y, Forrest AR, Standley DM, Date H, *Sakaguchi S; FANTOM Consortium.
Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation.
Proc Natl Acad Sci USA.   111: 5289-5294, 2014

*Arner E, Forrest AR, Ehrlund A, Mejhert N, Itoh M, Kawaji H, Lassmann T, Laurencikiene J, Ryden M, *Arner P; FANTOM Consortium.
Ceruloplasminin is a novel adipokine which is overexpressed in adipose tissue of obese subjects and in obesity-associated cancer cells.
PloS One.  9: e80274, 2014

Andersson R, Gebhard C, Miguel-Escalada I, Hoof I, Bornholdt J, Boyd M, Chen Y, Zhao X, Schmidl C, Suzuki T, Ntini E, Arner E, Valen E, Li K, Schwarzfischer L, Glatz D, Raithel J, Lilje B, Rapin N, Bagger FO, J_rgensen M, Andersen PR, Bertin N, Rackham O, Burroughs AM, Baillie JK, Ishizu Y, Shimizu Y, Furuhata E, Maeda S, Negishi Y, Mungall CJ, Meehan TF, Lassmann T, Itoh M, Kawaji H, Kondo N, Kawai J, Lennartsson A, Daub CO, Heutink P, Hume DA, Jensen TH, Suzuki H, Hayashizaki Y, M_ller F; FANTOM Consortium, *Forrest AR, *Carninci P, *Rehli M, *Sandelin A.; FANTOM Consortium
An atlas of active enhancers across human cell types and tissues.
Nature  507: 455-461, 2014

Hoshii T, Kasada A, Hatakeyama T, Ohtani M, Tadokoro Y, Naka K, Ikenoue T, Ikawa T, Kawamoto H, Fehling HJ, Araki K, Yamamura K, Matsuda S, *Hirao A.
Loss of mTOR complex 1 induces developmental blockade in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells. Proc.
Natl. Acad. Sci. USA.   111: 3805-3810. 2014

Suzuki K, Numata T, Suzuki H, Raga DD, ann Ipulan L, Ykoyama C, Matsushita S, Hamada M, Nakagata N, Nishinakamura R, Kume S, Takahashi S, Yamada G*.
Sexually dimorphic gene, MafB, regulates 1 masculinization of the external genitalia.
Proc Natl Acad Sci.USA  111: 16407-16412, 2014.

Wu L, Parekh VV, Hsiao J, Kitamura D, *Van Kaer L.
Spleen supports a pool of innate-like B cells in white adipose tissue that protects against obesity-associated insulin resistance.
Proc. Natl. Acad. Sci. USA  111: E4638-E4647. 2014.

Kobayashi M, Shelly CW, Seo W, Vemula S, Liu Y, Taniuchi I, *Yoshimoto M.
Functional B-1 progenitor cells are present in the hematopoietic stem cell deficient embryo and depend on Cbfβ for their development.
Proc. Natl. Acad. Sci. USA.  111:12151-6, 2014.

Iida, A., Iwagawa, T., Kuribayashi, H., Satoh. S., Mochizuki, Y., Baba, Y., Nakauchi, H., Furukawa, T, Koseki, H, Murakami, A., *Watanabe, S (2014)
Jmjd3 is required for the development of subsets of retinal bipolar cells.
Proc.Natl.Acad.Sci.,USA,  111: 3751-3756. 2014

Wada T, Koyama D, Kikuchi, J, Honda H, *Furukawa Y.
Overexpression of the shortest isoform of histone demethylase LSD1 primes hematopoietic stem/progenitor cells for malignant transformation.
Blood,  in press.

Wang C, Sashida G, Saraya A, Ishiga R, Koide S, Oshima M, Isono K, Koseki H, *Iwama A.
Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia.
Blood. 2014;  123(21): 3336-43.

Kameda T, Shide K, Yamaji T, Kamiunten A, Sekine M, Taniguchi Y, Hidaka T, Kubuki Y, Shimoda H, Marutsuka K, Sashida G, Aoyama K, Yoshimitsu M, Harada T, Abe H, Miike T, Iwakiri H, Tahara Y, Sueta M, Yamamoto S, Hasuike S, Nagata K, Iwama A, Kitanaka A, *Shimoda K.
Loss-of-TET2 has dual roles in murine myeloproliferative neoplasms: disease sustainer and disease accelerator.
Blood. 2015;  125(2): 304-15

riguchi S, Kikuchi N, Kaneko S*, Noguchi E, Morishima Y, Matsuyama M, Yoh Y, Takahashi S, Nakauchi H, Ishii Y*.
T cell-restricted T-bet overexpression induces aberrant hematopoiesis of myeloids and impairs function of macrophages in the lung.
Blood.  125: 370-382, 2015.

Taguchi K, *Okada A, Kitamura H, Yasui T, Naiki T, Hamamoto S, Ando R, Mizuno K, Kawai N, Tozawa K, Asano K, Tanaka M, Kohri K.
Colony-Stimulating Factor-1 Signaling Suppresses Renal Crystal Formation.
J Am Soc Nephrol.  25: 1680-1697. 2014

Karasawa K, Asano K, Moriyama S, Ushiki M, Monya M, Iida M, Kuboki E, Yagita H, Uchida K, Nitta K, *Tanaka M.
Vascular-Resident CD169-Positive Monocytes and Macrophages Control Neutrophil Accumulation in the Kidney with Ischemia-Reperfusion Injury
J Am Soc Nephrol.  2014 (Epub Ahead of Print)

Kihara M, Ito K, Nakata J, Otani M, Tran NL, Morito N, Takahashi S, Wada Y, Izui S*.
O-linked glycosylation determines the nephritogenic potential of IgA rheumatoid factor.
J Am Soc Nephrol.  25: 1282-1290,2014.

Morito N*, Yoh K, Ojima M, Okamura M, Nakamura M, Hamada M, Yamagata K, Takahashi S.
Overexpression of Mafb in podocytes protects against diabetic nephropathy.
J Am Soc Nephrol.  25: 2546-2557, 2014.

Koyama D, Kikuchi J, Hiraoka N, Wada T, Kurosawa H, Chiba S, *Furukawa Y.
Proteasome inhibitors exert cytotoxicity and increase chemosensitivity via transcriptional repression of Notch1 in T-cell acute lymphoblastic leukemia.
Leukemia  28: 1216-1226, 2014.

Wang CQ, Chin DW, Chooi JY, Wee Joo C, Taniuchi I, Tergaonkar V, *Osato M.
Cbfb deficiency results in differentiation blocks and stem/progenitor cell expansion in hematopoiesis.
Leukemia.  doi: 10.1038/leu.2014.316. 2014.

Koso, H, Tsuhako, A, Lyons, E, Ward, JM, Rust, AG, Adams, DJ, Jenkins, NA, Copeland, NG, *Watanabe, S Transposon mutagenesis identifies Foxr2 as a putative oncogene in medulloblastoma.
Can Res,  74: 2351-2361. 2014

*Tago K, Funakoshi-Tago M, Itoh H, Furukawa Y, Kikuchi J, Kato T, Suzuki K, Yanagisawa K.
Arf tumor suppressor disrupts the oncogenic positive feedback loop including c-Myc and DDX5.
Oncogene  34: 310-318, 2015.

Wang CQ, Krishnan V, Tay LS, Chin DW, Koh CP, Chooi JY, Nah GS, Du L, Jacob B, Yamashita N, Lai SK, Tan TZ, Mori S, Taniuchi I, Tergaonkar V, Ito Y, *Osato M.
Disruption of Runx1 and Runx3 leads to bone marrow failure and leukemia predisposition due to transcriptional and DNA repair defects.
Cell Reports.  8:767-8c2. 2014.

Nagao, M*, Lanjakornsiripan, D, Itoh, Y, Kishi, Y, Ogata, T, & Gotoh, Y .
High mobility group nucleosome-binding family proteins promote astrocyte differentiation of neural precursor cells.
Stem Cells,  32(11), 2983_2997. 2014

Katano M, Ema M, Nakachi Y, Mizuno Y, Hirasaki M, Suzuki A, Ueda A, Nishimoto M, Takahashi S, Okazaki Y, Okuda A*.
Forced expression of Nanog or Esrrb preserves the ESC status in the absence of nucleostemin expression.
Stem Cells.   in press.

Hishida T, Nakachi Y, Mizuno Y, Katano M, Okazaki Y, Ema M, Takahashi S, Hirasaki M, Suzuki A, Ueda A, Nishimoto M, Hishida-Nozaki Y, Vazquez-Ferrer E, Sancho-Martinez I, Belmonte JCI*, Okuda A*. Functional compensation between Myc and PI3K signaling supports self-renewal of embryonic stem cells.
Stem Cells.   in press.

Nishimura W*, Takahashi S, Yasuda K*.
MafA is critical for maintenance of the mature beta cell phenotype in mice.
Diabetologia.  in press.

Fukushima N, Ieda N, Sasakura K, Nagano T, Hanaoka K, Suzuki T, Miyata N, *Nakagawa H. Photocontrollable hydrogen sulfide donor using ketoprofenate photocages.
Chem. Commun.  50: 587-589. 2014.

Etani T, *Suzuki T, *Naiki T, Naiki-Ito A, Ando R, Iida K, Kawai N, Tozawa K, Miyata N, Kohri K, Takahashi S. NCL1, a highly selective lysine-specific demethylase 1 inhibitor, suppresses prostate cancer without adverse effect.
Oncotarget.  6: in press. 2015.

Tee A, Ling D, Nelson C, Atmadibrata B, Dinger M, Xu N, Mizukami T, Liu PY, Liu B, Cheung B, Pasquier E, Haber M, Norris MD, Suzuki T, Marshall GM, *Liu T.
The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1.
Oncotarget.   5: 1793-1804. 2014.

Qin X, Jiang Q, Matsuo Y, Kawane T, Komori H, Moriishi T, Taniuchi I, Ito K, Kawai Y, Rokutanda S, Izumi S, *Komori T.
Cbfb regulates bone development by stabilizing Runx family proteins.
J. Bone Miner. Res.  doi: 10.1002/jbmr.2379.

Omori-Miyake M, Yamashita M, Tunemi Y, Kawashima M, *Yagi J.
In vitro assessment of IL-4- or IL-13-mediated changes in the structural components of keratinocytes in mice and human.
J. Invest. Darmatol.  134: 1342-1350. 2014.

Takayama K, Noguchi Y, Aoki S, Takayama S, Yoshida M, Asari T, Yakushiji F, Nishimatsu S, Ohsawa Y, I Itoh F , Negishi Y, Sunada Y, *Hayashi Y.
Identification of the minimum Peptide from mouse myostatin prodomain for human myostatin inhibition.
J Med Chem.  58:1544-1549. 2015.

Nishikawa Y, Nishijima H, Matsumoto M, Morimoto J, Hirota F, Takahashi S, Luche H, Fehling HJ, Mouri Y, Matsumoto M*.
Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program.
J Immunol.  192: 2585-2592, 2014.

Iizuka M, Tsuboi H, Matsuo N, Asashima H, Hirota T, Kondo Y, Iwakura Y, Takahashi S, Matsumoto I, Sumida T*.
A crucial role of RORγt in the development spontaneous sialadenitis-like Sj_gren's syndrome.
J Immunol. 194: 56-67, 2015.

Minagawa K, Wakahashi K, Kawano H, Nishikawa S, Fukui C, Kawano Y, Asada N, Sato M, Sada A, Katayama Y, *Matsui T.
Posttranscriptional modulation of cytokine production in T cells for the regulation of excessive inflammation by TFL.
J. Immunol.  192: 1512-1524. 2014.

Kitabatake M, Soma M, Zhang T, Kuwahara K, Fukushima Y, Nojima T, Kitamura D, *Sakaguchi N.
JNK regulatory molecule G5PR induces IgG autoantibody-producing plasmablasts from peritoneal B1a cells.
J. Immunol.  194: 2015. in press.

Fukao S, Haniuda K, Nojima T, Takai T, * Kitamura, D.
Gp49B-mediated negative regulation of antibody production by memory and marginal zone B cells.
J. Immunol.  193: 635-644. 2014.

Omi T, Tanimukai H, Kanayama D, Sakagami Y, Tagami S, Okochi M, Morihara T, Sato M, Yanagida K, Kitasyoji A, Hara H, Imaizumi K, Maurice T, Chevallier N, Marchal S, Takeda M, *Kudo T.
Fluvoxamine alleviates ER stress via induction of Sigma-1 receptor.
Cell Death Dis.  5:e1332. 2014.

*Moriguchi T, Suzuki M, Yu L, Takai J, Ohneda K, *Yamamoto M.
Progenitor stage-specific activity of a cis-acting double GATA motif for Gata1 gene expression.
Mol Cell Biol.  35:805 -815. 2015.

*Ohneda K, Moriguchi T, Ohmori S, Ishijima Y, Satoh H, Philipsen S, Yamamoto M.
Transcription factor GATA1 is dispensable for mast cell differentiation in adult mice.
Mol Cell Biol.  34:1812-1826. 2014.

Taguchi K, Hirano I, Itoh T, Tanaka M,  Miyajima A, Suzuki A, Motohashi H, and Yamamoto M*.
Nrf2 enhances cholangiocyte expansion in Pten-deficient livers.
Mol. Cell. Biol.  34: 900-913, 2014.

Shinohara H, Taniguchi K, Kumazaki M, Yamada N, Ito Y, Otsuki Y, Uno B, Hayakawa F, Minami Y, Naoe T, *Akao Y.
Anti-cancer fatty-acid derivative induces autophagic cell death through modulation of PKM isoforms expression profile mediated by bcr-abl in chronic myeloid leukemia.
Cancer Letters. in press.

*Hayakawa F, Sakura T, Yujiri T, Kondo E, Fujimaki K, Sasaki O, Miyatake J, Handa H, Ueda Y, Aoyama Y, Takada S, Tanaka Y, Usui N, Miyawaki S, Suenobu S, Horibe K, Kiyoi H, Ohnishi K, Miyazaki Y, Ohtake S, Kobayashi Y, Matsuo K, Naoe T;
Japan Adult Leukemia Study Group (JALSG). Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: a phase II study by the Japan Adult Leukemia Study Group.
Blood Cancer J.  17;4: e252. 2014

Miyazaki T, Ikeda K, Horie-Inoue K, Kondo T, Takahashi S, Inoue S*.
EBAG9 modulates host immune defense against tumor formation and metastasis by regulating cytotoxic activity of T lymphocytes.
Oncogenesis.3: e126. 2014.

Yagai T, Miyajima A and Tanaka M*.
Semaphorin 3E secreted by damaged hepatocytes regulates the sinusoidal regeneration and liver fibrosis during liver regeneration.
American J. Pathology 184: 2250-2259, 2014.

Hino K, Saito A, Kido M, Kanemoto S, Asada R, Takai T, Cui M, Cui X, Hino K, Saito A, Kido M, Kanemoto S, Asada R, Takai T, Cui M, Cui X,Hino K, Saito A, Kido M, Kanemoto S, Asada R, Takai T, Cui M, Cui X, *Imaizumi K.
Master regulator for chondrogenesis, Sox9, regulates transcriptional activation of the endoplasmic reticulum stress transducer BBF2H7/CREB3L2 in chondrocytes.
J Biol Chem.  289:13810-20. 2014. " "

Nakano N, Maeyama K, Sakata N, Itoh F, Akatsu R, Nakata M, Katsu Y, Ikeno S, Togawa Y, Vo Nguyen TT, Watanabe Y, Kato M, *Itoh S.
C18 ORF1, a novel negative regulator of transforming growth factor-β signaling.
J. Biol. Chem.  289:12680-12692. 2014 .

Komori T, ,Tanaka M, Semba M, Miyajima A, and Morikawa Y*.
Deficiency of OSMRβ exacerbates high-fat diet-induced obesity and related metabolic disorders in mice.
J. Biol. Chem.  289: 13821-13837, 2014.

*Imaizumi K.
Master regulator for chondrogenesis, Sox9, regulates transcriptional activation of the endoplasmic reticulum stress transducer BBF2H7/CREB3L2 in chondrocytes.
J Biol Chem.  289:13810-20. 2014.

Ohno Y, Saeki K, Yasunaga S, Kurogi T, Suzuki-Takedachi K, Shirai M, Mihara K, Yoshida K, Voncken JW, Ohtsubo M, *Takihara Y.
Transcription of the Geminin gene is regulated by a negative-feedback loop.
Mol. Biol. Cell  25:1374-1383, 2014.

Whibley N, Maccallum DM, Vickers MA, Zafreen S, Waldmann H, Hori S, Gaffen SL, Gow NA, Barker RN, *Hall AM.
Expansion of Foxp3+ T-cell populations by Candida albicans enhances both Th17-cell responses and fungal dissemination after intravenous challenge.
Eur. J. Immunol. 44: 1069-1083. 2014.

Omi A, Enomoto Y*, Kiniwa T, Miyata N and Miyajima A*.
Mature resting Ly6Chigh natural killer cells can be reactivated by IL-15.
Eur. J. Immunol.  44:2638-47. 2014.

Nagahama K, Eto N, Sakakibara Y, Matsusita Y, Sugamoto K, Morishita K, *Suiko M.
Oligomeric proanthocyanidins from rabbiteye blueberry leaves inhibits the proliferation of human T-cell lymphotropic virus type 1-associated cell lines via apoptosis and cell cycle arrest
Journal of Functional Foods.  6:356_366. 2014.

Miyauchi S, Umekita K, Hidaka T, Umeki K, Aratake Y, Takahashi N, Sawaguchi A, Nakatake A, Morinaga I, Morishita K, *Okayama A.
Increased plasma lactoferrin levels in leucocytapheresis therapy in patients with rheumatoid arthritis.
Rheumatology (Oxford).   53:1966-72. 2014.

Mizoguchi Y, Tsumura M, Okada S, Hirata O, Minegishi S, Imai K, Hyakuna N, Muramatsu H, Kojima S, Yasunaga S, Takihara Y, Bryant V, Kong X-F, Cypowyj S, Boisson-Dupuis S, Puel A, Casanova J-L, Morio T, *Kobayashi M. Simple diagnosis of STAT1 gain-of-function alleles in patients with chronic mucocutaneous candidiasis presenting various clinical signs.
J. Leukoc. Biol.  95:667-676, 2014.

Sakaguchi S, Hombauer M, Hassan H, Tanaka H, Naoe Y, Bilic I, mayer H, Bergthaler A, Taniuchi I, *Ellmeier W.
A novel Cd8-cis regulatory element that directs expression in CD44+CD62L+CD8+ T cells and in CD8aa+ dendritic cells.
J. Leukoc. Biol.  2014 Dec 29. pii: jlb.1HI1113-597RR

Sha S, Zhou L, Yin J, Takamiya K, Furukawa K, Furukawa K, Sokabe M, *Chen L.
Deficits in cognitive function and hippocampal plasticity in GM2/GD2 synthase knockout mice.
Hippocampus.  24:369-82. 2014.

Okuda H, Tatsumi K, Horii-Hayashi N, Morita S, Okuda-Yamamoto A, Imaizumi K, *Wanaka A.
OASIS regulates chondroitin 6-O-sulfotransferase 1 gene transcription in the injured adult mouse cerebral cortex.
J Neurochem.  130:612-25. 2014.

Mochizuki, Y, Iida, A, Lyons, E, Kageyama, R, Nakauchi, H, Murakami, A, *Watanabe, S
Use of cell type-specific transcriptome to identify genes specifically involved in M_ller glia differentiation during retinal development,
Dev Neurobiol, 74: 426-437. 2014

ida, A, Iwagawa, T, Baba, Y, Satoh, S, Mochizuki, Y, Nakauchi, H, Furukawa, T, Koseki, H, Murakami, A, *Watanabe, S.
Roles Histone H3K27 tri-methylase Ezh2 in retinal proliferation and differentiation.
Dev Neurobiol,  in press. 2015

Kuribayashi, H, Baba, Y, *Watanabe, S. BMP signaling participates in late phase differentiation of the retina, party via upregulation of Hey2.
Dev Neurobiol,  74:1172-1183. 2014

Matsuba S, Niwa S, Muraki K, Kanatsuka S, Nakazono Y, Hatano N, Fujii M, Zhan P, Suzuki T, *Ohya S. Downregulation of Ca2+-activated Cl- channel TMEM16A by the inhibition of histone deacetylase in TMEM16A-expressing cancer cells.
J. Pharmacol. Exp. Ther.  351: 510-518. 2014.

 Toyota H, Sudo K, Kojima K, Yanase N, Nagao T, Takahashi RH, Iobe H, Kuwabara T, Kakiuchi T, *Mizuguchi J.
Thy28 protects against anti-CD3-mediated thymic cell death in vivo.
Apoptosis.  2014 Dec 30.

Sato F, Miyaoka Y, Miyajima A and Tanaka M*.
Oncostatin M maintains the hematopoietic microenvironment in the bone marrow by affecting adipogenesis and osteoblastogenesis.
PLoS One,  e116209, 2014.

Moutai T, Yamana H, Nojima T, *Kitamura D.
A novel and effective cancer immunotherapy mouse model using antigen-specific B cells selected in vitro. PLoS One   9: e92732. 2014.

Prickaerts P, Niessen HEC, Dahlmans VEH, Salvaing J, Vanhove J, Spaapen F, Geijselaers C, Partouns I, Bartels SJJ, Neumann D, Speel EJ, Takihara Y, Wouters BG, *Voncken JW.
MK3 modulation affects BMI1-dependent and independent cell cycle check-points.
PLoS ONE   in press, 2015.

Hiraoka N, Kikuchi J, Yamauchi T, Koyama D, Wada T, Uesawa M, Akutsu M, Mori S, Nakamura Y, Ueda T, Kano Y, *Furukawa Y.
Purine analog-like properties of bendamustine underlie rapid activation of DNA damage response and synergic effects with pyrimidine analogues in lymphoid malignancies.
PLoS One   9: e90675, 2014.

Sato F, Miyaoka Y, Miyajima A and Tanaka M*.
Oncostatin M maintains the hematopoietic microenvironment in the bone marrow by affecting adipogenesis and osteoblastogenesis.
PLoS One, e116209, 2014.

Terayama H, *Yoshimoto T, Hirai S, Naito M, Qu N, Hatayama N, Hayashi S, Mitobe K, Furusawa J, Mizoguchi I, Kezuka T, Goto H, Suyama K, Moriyama H, Sakabe K, Itoh M.
Contribution of IL-12/IL-35 common subunit p35 to maintaining the testicular immune privilege.
PLoS One,  23;9(4):e96120. 2014 Apr

Kusaka T, Nakayama M, Nakamura K, Ishimiya M, Furusawa E, *Ogasawara K.
Effect of silica particle size on macrophage inflammatory responses.
PLoS ONE.  e92634, 2014

Mano T, Suzuki T,
Differential effect of HDAC3 on cytoplasmic and nuclear Huntingtin aggregates.
PLoS ONE.  : e111277. 2014.

Eto K, Nishimura W*, Oishi H, Udagawa H, Kawaguchi M, Hiramoto M, Fujiwara T, Takahashi S, Yasuda K*. MafA is required for postnatal proliferation of pancreatic β-cells.
Plos One.  9(8): e104184, 2014.

Nagasaki H, Katsumata T, Oishi H*, Tai P-H, Sekiguchi Y, Koshida R, Jung Y, Kudo T, Takahashi S . Generation of insulin-producing cells from the mouse liver using β cell-related gene transfer including Mafa and Mafb.
Plos One.  9(11): e113022, 2014.

Yoshida Y, Hayashi Y, Suda M, Tateno K, Okada S, Moriya J, Yokoyama M, Nojima A ,Yamashita M, Kobayashi Y, Shimizu I, *Minamino T.
Notch signaling regulates the lifespan of vascular endothelial cells via p16-dependent pathway.
Plos One.   9: 1e100359. 2014.

Kawano M, Nakayama M, Aoshima Y, Nakamura K, Ono M, Nishiya T, Nakamura S, Takeda Y, Dobashi A, Takahashi A, Endo M, Ito A, Ueda K, Sato N, Higuchi S, Kondo T, Hashimoto S, Watanabe M, Watanabe M, Takahashi T, Sasaki K, Nakamura M, Sasazuki T, Narushima T, Suzuki R, *Ogasawara K.
NKG2D+ IFN-gamma CD8+ T cells are responsible for palladium allergy.
PLoS ONE.   e86810, 2014

Kondo Y, Iwao T, Yoshihashi S, Mimori K, Ogihara R, Nagata K, Kurose K, Saito M, Niwa T, Suzuki T, Miyata N, Ohmori S, Nakamura K, *Matsunaga T.
Histone deacetylase inhibitor valproic acid promotes the differentiation of human induced pluripotent stem cells into hepatocyte-like cells.
PLoS ONE.  9: e104010. 2014.

Hayashi-Takanaka Y, Stasevich TJ, Kurumizaka H, Nozaki N, *Kimura H
Evaluation of chemical fluorescent dyes as a protein conjugation partner for live cell imaging.
PLoS One.   9(9):e106271. 2014.

Naono-Nakayama R, Ikeda T, Matsushima O, Sameshima H, Takamiya K, Funahashi H, *Nishimori T.
An amino-terminal fragment of hemokinin-1 has an inhibitory effect on pruritic processing in rats.
Neuroscience.  259:172-83. 2014.

Tahara M, Kondo Y, Yokosawa M, Tsuboi H, Takahashi S, Shibayama S, Matsumoto I, Sumida T*.
T-bet regulates differentiation of Foxp3+ regulatory T cells in programmed cell death-1-deficient mice.
Clin Exp Immunol.  179: 197-209, 2015.

*Stasevich TJ, Sato Y, Nozaki N, *Kimura H.
Quantifying histone and RNA polymeraseｃ II post-translational modification dynamics in mother and daughter cells.
Methods.  70(2-3): 77-78. 2014.

*Singh RK, Suzuki T, Mandal T, Balsubramanian N, Haldar M, Mueller DJ, Strode JA, Cook G, Mallik S, *Srivastava DK.
Binding Thermodynamics of Structurally Similar Ligands to Histone Deacetylase 8 Sheds Light on Challenges in Rational Design of Potent and Isozyme-selective Inhibitors of the Enzyme.
Biochemistry.  53: 7445-7458. 2014.

Yabe R, Shimizu K, Shimizu S, Azechi S, Choi BI, Sudo K, Kubo S, Nakae S, Ishigame H, Kakuta S, *Iwakura Y.
CCR8 regulates contact hypersensitivity by restricting cutaneous dendritic cell migration to the draining lymph nodes.
Int. Immunol.  2014 Oct 25. pii: dxu098.

Watanabe M, Kudo Y, Kawano M, Nakayama M, Nakamura K, Kameda M, Ebara M, Sato T, Nakamura M, Omine K, Kametani Y, Suzuki R, *Ogasawara K.
NKG2D functions as an activating receptor on natural killer cells in the common marmoset (Callithrix jacchus).
Int. Immunol.  11: 597-606, 2014

Maruyama S, Kanoh M, Matsumoto A, Kuwahara M, Yamashita M, *Asano Y.
A novel function of Interferon regulatory factor 1: Inhibition of Th2 cells by down-regulating the Il4 gene during Listeria infection.
Int. Immunol. Advanced access published. 2014.

Iida, A, Tabata, Y, Baba, Y, Fujii, T, *Watanabe, S.
Critical Roles of DNase1l3l in Lens Nuclear Degeneration in Zebrafish.
Biochimie,  106: 68-74

Sekizawa H, Amaike K, Itoh Y, *Suzuki T, *Itami K, *Yamaguchi J.
Late-stage C_H coupling enables rapid identification of HDAC inhibitors: synthesis and evaluation of NCH-31 analogues.
ACS Med. Chem. Lett. 5: 582-586. 2014.

*Suzuki T, Muto N, Bando M, Itoh Y,　Masaki A, Ri M, Ota Y, Nakagawa H, Iida S, Shirahige K, Miyata N. Design, synthesis, and biological activity of NCC149 derivatives as histone deacetylase 8-selective inhibitors.
ChemMedChem.  9: 657-664. 2014.

Ohyashiki JH, Ohtsuki K, Mizoguchi I, Yoshimoto T, Katagiri S, Umezu T, *Ohyashiki K.
Down-regulated microRNA-148b in circulating PBMCs in chronic myeloid leukemia patients with undetectable minimal residual disease: A possible molecular classifier to stop imatinib safely.
Drug Des. Devel. Ther.  8: 1151-1159. 2014.

Yamasaki M, Nishimura M, Sakakibara Y, Suiko M, Morishita K, *Nishiyama K.
Delta-tocotrienol induces apoptotic cell death via depletion of intracellular squalene in ED40515 cells.
Food Funct.  5:2842-9. 2014.

Mino T, *Mihara K, Yoshida T, Takihara Y, Ichinohe T.
Monthly administration of rituximab is useful for patients with ocular adnexal mucosa-associated lymphoid tissue lymphoma.
Blood Cancer J.  12;4:e245. doi: 10.1038/bcj.2014.65, 2014.

Mizuno S, Dinh TT, Kato K, Mizuno-Iijima S, Tanimoto Y, Daitoku Y, Hoshino Y, Ikawa M, Takahashi S, Sugiyama F*, Yagami KI.
Simple generation of albino C57BL/6J mice with G291T mutation in the tyrosinase gene by the CRISPR/Cas9 system.
Mamm Genome.  25: 327-334, 2014.

Kobayashi S, Yamashita T, Ohneda K, Nagano M, Kimura K, Nakai H, Poellinger L, *Ohneda O. Hypoxia-inducible factor-3α promotes angiogenic activity of pulmonary endothelial cells by repressing the expression of the VE-cadherin gene.
Genes Cells.  2015 In press

Abdul Razak, SA, Baba, Y, Nakauchi, H, Otsu, M, *Watanabe, S. DNA methylation is involved in the expression of miR-142-3p in fibroblasts and induced pluripotent stem cells.
Stem Cells International,  e101349. 2014

Martinez NE, Sato F, Omura S, Kawai E, Takahashi S, Yoh K, Tsunoda I*.
RORγt, but not T-bet, overexpression exacerbates an autoimmune model for multiple sclerosis.
J Neuroimmunol. 276: 142-149, 2014.

Wada N, Kawano Y, Fujiwara S, Kikukawa Y, Okuno Y, Tasaki M, Ueda M, Ando Y, Yoshinaga K, Ri M, Iida S, Nakashima T, Shiotsu Y, Mitsuya H, *Hata H Shikonin,
Dually functions as a proteasome inhibitor and a necroptosis inducer in multiple myeloma cells.
Int J Oncol.  46: 963-972. 2015.

Islam MN, Itoh S, Yanagita T, Sumiyoshi K, Hayano S, Kuremoto KI, Kurosaka H, Honjo T, Kawanabe N, Kamioka H, Sakai T, Ishimaru N, Taniuchi I, *Yamashiro T.
Runx/Cbfb signaling regulates postnatal development of granular convoluted tubule in the mouse submandibular gland.
Dev Dyn.  doi: 10.1002/dvdy.24231.

Khan MNA, Tsumoto H, Itoh Y, Ota Y, Suzuki M, Ogasawara D, Nakagawa H, Mizukami T, Miyata N, *Suzuki T. Design, synthesis, and biological activity of N-alkylated analogue of NCL1, a selective inhibitor of lysine-specific demethylase 1.
MedChemComm.   6: in press. 2015.

Toyota H, Yanase N, Yoshimoto T, Harada M, Kato Y, *Mizuguchi J.
Vaccination with OVA-bound nanoparticles encapsulating IL-7 inhibits the growth of OVA-expressing E.G7 tumor cells in vivo.
Oncol.  Rep. 3: 292-296. 2015.

Muto T, Sashida G, Hasegawa N, Nakaseko C, Yokote K, Shimoda K, *Iwama A.
MDS with extramedullary erythroid hyperplasia induced by loss of Tet2 in mice.
Leuk Lymphoma.  2014; 21: 1-9.

Yamasaki M, Harada E, Tamura Y, Lim SY, Ohsuga T, Yokoyama N, Morishita K, Nakamura K, Ohta H, *Takiguchi M.
In vitro and in vivo safety and efficacy studies of amphotericin B on Babesia gibsoni.
Vet Parasitol.  205:424-33. 2014.

Osada Y, Yamada S, Nakae S, Sudo K, *Kanazawa T.
Reciprocal effects of Schistosoma mansoni infection on spontaneous autoimmune arthritis in IL-1 receptor antagonist-deficient mice.
Parasitol. Int.  2015 Feb;64(1):13-17.

Tatum PR, Sawada H, Ota Y, Itoh Y, Zhan P, Ieda N, Nakagawa H, Miyata N, *Suzuki T.
Identification of novel SIRT2-selective inhibitors using a click chemistry approach.
Bioorg. Med. Chem. Lett.  24: 1871-1874. 2014.

Kitamura K, Ieda N, Hishikawa K, Suzuki T, Miyata N, Fukuhara K, *Nakagawa H.
Visible light-induced nitric oxide release from a novel nitrobenzene derivative cross-conjugated with a coumarin fluorophore.
Bioorg. Med. Chem. Lett.  24: 5660-5662. 2014.

 Shimura E, Shibui A, Narushima S, Nambu A, Yamaguchi S, Akitsu A, Leonard WJ, Iwakura Y, Matsumoto K, Suto H, Okumura K, Sudo K, *Nakae S.
Potential role of myeloid cell/eosinophil-derived IL-17 in LPS-induced endotoxin shock.
Biochem. Biophys. Res. Commun.  2014 Oct 10;453(1):1-6.

Arai, E, Baba, Y, Iwagawa, T, Kuribayashi, H, Mochizuki, Y, *Watanabe, S.
Ablation of Kcnj10 expression in retinal explants revealed pivotal roles for Kcnj10 in the proliferation and development of M_ller glia.
Mol Vis,  in press. 2015

*Ichijo H, Hamada M, Takahashi S, Kobayashi M, Nagai T, Toyama T, Kawaguchi M.
Lateralization, maturation, and anteroposterior topography in the lateral habenula revealed by ZIF268/EGR1 immunoreactivity and labeling history of neuronal activity.
Neurosci. Res.  2015. in press.

Nishimura W*, Oishi H, Funahashi N, Fujiwara Takahashi S, Yasuda K*.
Generation and characterization of MafA-Kusabira Orange mice.
Endocr J.  in press.

Nagai K, Nakahata S, Shimosaki S, Tamura T, Kondo Y, Baba T, Taki T, Taniwaki M, Kurosawa G, Sudo Y, Okada S, Sakoda S, *Morishita K.
Development of a complete human anti-human transferrin receptor C antibody as a novel marker of oral dysplasia and oral cancer.
Cancer Med.  3:1085-99. 2014.

Kikukawa Y, Yuki H, Hirata S, Ide K, Nakata H, Miyakawa T, Matsuno N, Nosaka K, Yonemura Y, Kawaguchi T, Hata H, Mitsuya H, *Okuno Y.
Combined use of bortezomib, cyclophosphamide, and dexamethasone induces favorable hematological and organ responses in Japanese patients with amyloid light-chain amyloidosis: a single-institution retrospective study.
Int J Hematol.  In press.

*Yoshida Y, Oguma S, Ohno H, Nakabo Y, Katsurada T, Kawahara M, Kawabata H.
Co-occurrence of monoclonal gammopathy and myelodysplasia: a retrospective study of fourteen cases.
Int. J. Hematol.  99: 721-725. 2014

Kikuchi J, Koyama D, Mukai HY, *Furukawa Y.
Suitable drug combination with bortezomib for multiple myeloma under stroma-free conditions and in contact with fibronectin or bone marrow stroma.
Int. J. Hematol.  99: 726-736, 2014.

Mino K, Nishimura S, Ninomiya S, Tujii H, Matsumori Y, Tsuchida M, Hosoi M, Koseki K, Wada S, Hasegawa M, Sasaki R, Murakami-Yamaguchi Y, Narita H, Suzuki T, Miyata N, *Mizukami T.
Regulation of tissue factor pathway inhibitor-2 (TFPI-2) expression by lysine-specific demethylase 1 and 2 (LSD1 and LSD2).
Biosci. Biotech. Biochem.  78: 1010-1017. 2014.

Nagai Y, *Kawahara M, Sugino N, Shimazu Y, Hishizawa M, Yamashita K, Kadowaki N, Takaori-Kondo A:
A case of minor BCR-ABL1 positive acute lymphoblastic leukemia following essential thrombocythemia and originating from a clone distinct from that harboring the JAK2-V617F mutation.
Experimental Hematology & Oncology  3:6. 2014 doi:10.1186/2162-3619-3-6

Okamura M, Yoh K*, Ojima M, Morito N, Takahashi S*.
Overexpression of GATA-3 in T cells accelerates dextran sulfate sodium Induced colitis.
Exp Animal.  63: 133-140, 2014.

Hasegawa Y, Daitoku Y, Mizuno S, Tanimoto Y, Mizuno-Iijima S, Matsuo M, Kajiwara N, Ema M, Oishi H, Miwa Y, Mekada K, Yoshiki A, Takahashi S, Sugiyama F*, Yagami K.
Generation and Characterization of Ins1-cre-driver C57BL/6N for Exclusive Pancreatic Beta Cell-specific Cre-loxP Recombination.
Exp Animal.  63: 183-191, 2014.

Tran MT, Tanaka J, Hamada M, Sugiyama Y, Sakaguchi S, Nakamura M, Takahashi S, Miwa Y*.
In vivo image analysis using iRFP transgenic mouse.
Exp Animal.  63: 311-319, 2014.

toh Y, Ogasawara D, Ota Y, Mizukami T, *Suzuki T.
Synthesis, LSD1 inhibitory activity, and LSD1 binding model of optically pure lysine-PCPA conjugates.
Comput. Struct. Biotechnol. J.  9: e201402002. 2014.

Kai H, Akamatsu E, Torii E, Kodama H, Yukizaki C, Akagi I, Ino H, Sakakibara Y, Suiko M, Yamamoto I, Okayama A, Morishita K, Kataoka H, *Matsuno K:
Identification of a bioactive compound against adult T-cell leukemia from bitter gourd seeds.
Plants  3:18-26 2014.

Sripayap P, *Nagai T, Hatano K, Kikuchi J, Furukawa Y, Ozawa K.
Romidepsin overcomes cell adhesion-mediated drug resistance in multiple myeloma cells.
Acta Haematol.  132: 1-4, 2014.

*Hayakawa F, Tomita A, Naoe T.
Development of acute pure red cell aplasia after deferasirox administration in two cases of myelodysplastic syndrome.
Rinsho Ketsueki.  55: 445-9. 2014