2013年度 - 原著論文

* correspondence

Omatsu Y, Seike M, Sugiyama T,, Kume T, *Nagasawa T.
Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation.
Nature.  24;508(7497):536-40.2014

Nishiyama A, Yamaguchi L, Sharif J, Johmura Y, Kawamura T, Nakanishi K, Shimamura S, Arita K, Kodama T, Ishikawa F, Koseki H,*Nakanishi M .
Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication.
Nature. 12488.2013

Furusawa Y, Obata Y, Fukuda S, Endo TA, Nakata G, Takahashi D, Nakanishi Y,
Uetake C, Kato K, Kato T, Takahashi M, Fukuda NN, Murakami S, Miyauchi E,Hino S,
Atarashi K, Onawa S, Fujimura Y, Lockett T, Clarke JM, Topping DL, Tomita M, Hori S,
Ohara O, Morita T, Koseki H, Kikuchi J, Honda K, Hase K, *Ohno H.
Commensal microbe-derived butyrate induces the differentiation of colonic
regulatory T cells.
Nature. 504: 446-50. 2013.

Kon A, Shih LY, Minamino M, Sanada M, Shiraishi Y, Nagata Y, Yoshida K, Okuno Y, Bando M, Nakato R, Ishikawa S, Sato-Otsubo A, Nagae G, Nishimoto A, Haferlach C, Nowak D, Sato Y, Alpermann T, Nagasaki M, Shimamura T, Tanaka H, Chiba K, Yamamoto R, Yamaguchi T, Otsu M, Obara N, Sakata-Yanagimoto M, Nakamaki T, Ishiyama K, Nolte F, Hofmann WK, Miyawaki S, Chiba S, Mori H, Nakauchi H, Koeffler HP, Aburatani H, Haferlach T, Shirahige K, Miyano S, *Ogawa S.
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.
Nat Genet. 45(10):1232-1237, 2013.

Yoshida K, Toki T, Okuno Y, Kanezaki R, Shiraishi Y, Sanada M, Park M, Terui K, Kon A, Nagata Y, Sato-Otsubo A, Sato Y, Wang R, Shiba N, Chiba K, Tanaka H, Hama A, Muramatsu H, Hasegawa D, Nakamura K, Kanegane H, Tsukamoto K, Adachi S, Kawakami K, Kato K, Nishimura R, Izraeli S, Hayashi Y, Miyano S, Kojima S, *Ito E, *Ogawa S.
Landscape of gene mutations in Down syndrome-related myeloid disorders.
Nat Genet. 45: 1293–1299. 2013.

Mucida D, Husain M.M, Muroi S, van Wijk F, Shinnakasu R, Naoe Y, Reis B, Huang Y, Lambolez F, Docherty M, Attinger A, Shui J.W, Kim G, Lena C, Sakaguchi S, Miyamoto C, Wang P, Atarashi K, Park Y, Nakayama T, Honda K, Ellmeier W, Kronenberg M, *Taniuchi I and *Cheroutre H. Transcriptional Reprogramming of Mature CD4 T helper Cells generates distinct MHC class II restricted Cytotoxic T Lymphocytes.
Nat. Immunol. 14: 281-9. 2013.

Reis B, Rogoz A, Costa-Pinto F, Taniuchi I and *Mucida D.
Mutual expression of Runx3 and ThPOK regulates intestinal CD4 T cell immunity.
Nat. Immunol. 14:271-80. 2013.

Shinagawa T, Takagi T, Tsukamoto D, Tomaru C, Huynh LM, Sivaraman P, Kumarevel T, Inoue K, Nakato R, Katou Y, Sada T, Takahashi S, Ogura A, Shirahige K, *Ishii S.
Histone variants enriched in oocytes enhance reprogramming to induced pluripotent stem cells.
Cell Stem Cell. 6;14(2):217-27.2014.

Asada N, *Katayama Y, Sato M, Minagawa K, Wakahashi K, Kawano H, Kawano Y, Sada A, Ikeda K,
Matsui T, Tanimoto M.
Matrix-embedded osteocytes regulate mobilization of hematopoietic stem/progenitor cells.
Cell Stem Cell. 12: 737-747. 2013.

Vizcardo R, Masuda K, Yamada D, Ikawa T, Shimizu K, Fujii S-I, Koseki H, *Kawamoto H.
Regeneration of human tumor antigen-specific T cells from iPS cells derived from mature CD8+ T cells.
Cell Stem Cell. 12: 31-36. 2013.

Nagamachi A, Matsui H, Asou H, Ozaki Y, Aki D, Kanai A, Takubo K, Suda T, Nakamura T, Wolff L, Honda H, *Inaba T.
Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.
Cancer Cell. 24: 305-317. 2013.

ΨOchiai K, ΨMaienschein-Cline M, Chen J, Chong AS, Dinner AR, *Singh H, *Sciammas R.
Transcriptional Regulation of Germinal Center B and Plasma Cell Fates by Dynamical Control of IRF4.
Immunity, May 23;38(5):918-29. 2013. Ψco-first authors

*Oh-hora M, Komatsu N, Pishyareh M, Feske S, Hori S, Taniguchi M, *Rao A, Takayanagi H.
Agonist-selected T cell development requires strong T cell receptor signaling and store-operated calcium entry.
Immunity. 38: 881-895. 2013.

Saito A, Kanemoto S, Zhang Y, Asada R, Hino K, *Imaizumi K.
Chondrocyte Proliferation Regulated by Secreted Luminal Domain of ER Stress Transducer BBF2H7/CREB3L2.
Mol Cell. 13: 833-842. 2013

Ichimura Y, Waguri S, Sou YS, Kageyama S, Hasegawa J, Ishimura R, Saito T, Yang Y, Kouno T,
Fukutomi T, Hoshii T, Hirao A, Takagi K, Mizushima T, Motohashi H, Lee MS, Yoshimori T,
Tanaka K, Yamamoto M, *Komatsu M.
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
Mol Cell. 51:618-31. 2013

Sato M, Asada N, Kawano Y, Wakahashi K, Minagawa K, Kawano H, Sada A, Ikeda K, Matsui T,
*Katayama Y.
Osteocytes regulate primary lymphoid organs and fat metabolism.
Cell Metabolism. 18: 749-758. 2013.

Ogasawara D, Itoh Y, Tsumoto H, Kakizawa T, Mino K, Fukuhara K, Nakagawa H, Hasegawa M, Sasaki R, *Mizukami T, *Miyata N, *Suzuki T.
Lysine-specific demethylase 1-selective inactivators: protein-targeted drug delivery mechanism.
Angew. Chem. Int. Ed. 52: 8620-8624. 2013.

Muto T, Sashida G, Oshima M, Wendt GR, Mochizuki-Kashio M, Nagata Y, Sanada M, Miyagi S, Saraya A, Kamio A, Nagae G, Nakaseko C, Yokote K, Shimoda K, Koseki H, Suzuki Y, Sugano S, Aburatani H, Ogawa S, *Iwama A.
Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders.
J Exp Med. 210:2627-2639. 2013.

Daussy C, Faure F, Mayol K, Viel S, Charrier E, Bienvenu J, Henry T, Debien E, Hasan U, Marvel J, Yoh K, Takahashi S, Di Santo JP, Prinz I, De Bernard S, Buffat L, *Walzer T.
T-bet and Eomes instruct the development of two distinct Natural Killer cell lineages in the
liver and bone marrow.
J Exp Med. 10;211(3):563-77. 2014

*Baba T, Naka K, Morishita S, Komatsu N, Hirao A, Mukaida N.
MIP-1α/CCL3-mediated maintenance of leukemia-initiating cells in the initiation process of
chronic myeloid leukemia.
J Exp Med. 210: 2661-73. 2013

Oudhoff MJ, Freeman SA, Couzens AL, Antignano F, Kuznetsova E, Min PH, Northrop JP,
Lehnertz B, Barsyte-Lovejoy D, Vedadi M, Arrowsmith CH, Nishina H, Gold MR, Rossi FMV,
Gingras AC, Zaph C.
Control of the Hippo pathway by Set7-dependent methylation of Yap.
Dev. Cell. 26: 188-194. 2013.

Caganova M, Carrisi C, Varano G, Mainoldi F, Zanardi F, Germain PL, George L, Alberghini F, Ferrarini L, Talukder AK, Ponzoni M, Testa G, Nojima T, Doglioni C, Kitamura D, Toellner KM, Su IH,
*Casola S.
Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis.
J Clin Invest. 123: 5009-5022. 2013.

Inoue D, Kitaura J, Togami K, Nishimura K, Enomoto Y, Uchida T, Kagiyama Y, Kawabata K.C,
Nakahara F, Izawa K, Oki T, Maehara A, Isobe M, Tsuchiya A, Harada Y, Harada H, Ochiya T,
Aburatani A, Kimura H, Thol F, Heuser M, Levine R.L, Abdel-Wahab O, *Kitamura T.
Myelodysplastic syndromes are induced by histone methylation-altering ASXL1 mutations.
J. Clin. Invest. 123: 4627-4640, 2013.

Takase H., *Itoh T., Wang T., Koji T., Akira S., Takikawa Y., and Miyajima A.
FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that
support liver regeneration.
Genes Dev. 27, 169-181, 2013.

Sadaie M, Salma R, Carroll T, Tomimatsu K, Chandra T, Young AR, Narita M, Pérez-Mancera, Bennett DC, Chong H, Kimura H, *Narita M.
Uneven alterations in the lamin B1 genomic profile regulate heterochromatin formation and gene
expression during senescence.
Genes Dev. 27: 1800-1808, 2013.

Izawa K, Isobe M, Matsukawa T, Ito S, Maehara A, Takahashi M, Yamanishi Y, Kaitani A, Oki T,
Okumura K, *Kitamura, T, *Kitaura J.
Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FceRI-mediated mast cell activation.
J. Allergy. Clin. Immunol. 133: 270-273, 2014.

Izawa K, Isobe M, Matsukawa T, Ito S, Maehara A, Takahashi M, Yamanishi Y, Kaitani A, Oki T,
Okumura K, *Kitamura, T, *Kitaura J.
Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting
FceRI-mediated mast cell activation. 
J. Allergy. Clin. Immunol. 133: 270-273, 2014.

Kamae C, Nakagawa N, Sato H, Honma K, Mitsuki N, Ohara O, Kanegane H, Pasic S,
Pan-Hammarstrom Q, Van Zelm MC, Morio T, Imai K, Nonoyama S.
Common variable immunodeficiency classification by quantifying T-cell receptor and immunoglobulin κ-deleting recombination excision circles.
J. Allergy. Clin. Immunol. 131: 1437-40. 2013.

Gailhouste L., Gomez-Santos L., Kitagawa N., Kawaharada K., Tirion M., Kosaka N., Takahashi R., Shibata T., Miyajima A., and *Ochiya T.
MiR-148a plays a pivotal role in the liver by promoting the hepatospecific phenotype and suppressing the Invasiveness of transformed cells.
Hepatology, 58(3):1153-1165, 2013.

Saito Y, Yuki H, Kuratani M, Hashizume Y, Takagi S, Honma T, Tanaka A, Shirouzu M, Mikuni J, Handa N, Ogahara I, Sone A, Najima Y, Tomabechi Y, Wakiyama M, Uchida N, Tomizawa-Murasawa M, Kaneko A, Tanaka S, Suzuki N, Kajita H, Aoki Y, Ohara O, Shultz LD, Fukami T, Goto T, Taniguchi S, Yokoyama S, *Ishikawa F.
A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo.
Sci Transl Med. 5: 181ra52. doi: 10.1126/scitansimed. 3004387. 2013.

Shi N, Hiraga N, Imamura M, Hayes CN, Zhang Y, Kosaka K, Okazaki A, Murakami E, Tsuge M, Abe H,
Aikata H, Takahashi S, Ochi H, Tateno-Mukaidani C, Yoshizato K, Matsui H, Kanai A, Inaba T,
McPhee F, Gao M, *Chayama K.
Combination therapies with NS5A, NS3 and NS5B inhibitors on different genotypes of hepatitis C virus in human hepatocyte chimeric mice.
Gut. 62: 1055-1061. 2013.

Kawai K, Ieda N, Aizawa K, Suzuki T, Miyata N, *Nakagawa H.
A Reductant-resistant and metal-free fluorescent probe for nitroxyl applicable to living cells.
J. Am. Chem. Soc. 135: 12690-12696. 2013.

Saito Y, Kaneda K, Suekane A, Ichihara E, Yamakawa N, Nagai K, Mizuno N, Kogawa K, Miura I, Itoh H, *Morishita K
Maintenance of the hematopoietic stem cell pool in bone marrow niches by EVI1-regulated GPR56.
Leukemia. 27: 1637-1649 2013.

*Suzuki HI, Matsuyama H, Noguchi M, Yao T, Komatsu N, Mano H, Sugimoto K, *Miyazono K.　 Computational dissection of distinct microRNA activity signatures associated with peripheral T cell lymphoma subtypes.
Leukemia. 27: 2107-2111. 2013.

Koyama D, Kikuchi J, Hiraoka N, Wada T, Kurosawa H, Chiba S,, *Furukawa Y.
Proteasome inhibitors exert cytotoxicity and increase chemosensitivity via transcriptional repression of Notch1 in T-cell acute lymphoblastic leukemia.
Leukemia. published online on December 4; doi:10.1038/leu.2013.366, 2013.

*Hamada M, Nakamura M, Moriguchi T, Ohsumi T, Kusakabe M, Hattori M, Matsui A, Kudo T, Wu C-H, Kao P-H, Arai S, Sakai M, Shimano H, Miyazaki T, *Takahashi S.
MafB promotes atherosclerosis by inhibiting foam cell apoptosis.
Nat Commun. Volume 5, id. 3147.2014

Nakajima K, Maekawa Y, Kataoka K, Ishifune C, Nishida J, Arimochi H, Kitamura A, Yoshimoto T,
Tomita S, Nagahiro S, *Yasutomo K.
The ARNT-Stat3 axis regulates the differentiation of intestinal intraepithelial TCRαβ+CD8αα+ cells.
Nat Commun. 4:2112.2013

Kabata H, Moro K, Fukunaga K, Suzuki Y, Miyata J, Masaki K, Betsuyaku T, *Koyasu S, *Asano K.
Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation.
Nat Commun. 4: 2675. 2013.

Nakashima K, Arai S, Suzuki A, Nariai Y, Urano T, Nakayama M, Ohara O, Yamamura K,
Yamamoto K, *Miyazaki T.
PAD4 regulates proliferation of multipotent haematopoietic cells by controlling c-myc expression.
Nat. Commun. 4: 1836.doi:10.1038/ncomms2862. 2013.

Tsunematsu T, Takihara Y, Ishimura N, Pagano M, Takata T, *Kudo Y.
Aurora-A controls pre-replicative complex formation and DNA replication by promoting the
stabilization of geminin in mitosis.
Nature Commun. 4:1885. doi: 10.1038 ncomms2859. 2013.

Yuki H, Ueno S, Tatetsu H, Niiro H, Iino T, Endo S, Kawano Y, Komohara Y, Takeya M, Hata H, Okada S, Watanabe T, Akashi K, Mitsuya H and *Okuno Y.
PU.1 is a potent tumor suppressor in classical Hodgkin lymphoma cells.
Blood. 121:962-970. 2013.

Nakajima-Takagi Y, *Osawa M, Oshima M, Takagi H, Miyagi S, Endoh M, Endo TA, Takayama N, Eto K, Toyoda T, Koseki H, Nakauchi H, *Iwama A.
Role of SOX17 in hematopoietic development from human embryonic stem cells.
Blood. 121, 447-458. 2013.

Takai J, *Moriguchi T, Suzuki M, Yu L, Ohneda K, *Yamamoto M.
The Gata1 5' region harbors distinct cis-regulatory modules that direct gene activation in erythroid cells and gene inactivation in HSCs.
Blood. 122:3450-3460. 2013.

Yokoyama K, Yokoyama N, Izawa K, Kotani A, Harashima A, Hozumi K, * Tojo A.
In vivo leukemogenic potential of an interleukin 7 receptor α chain mutant in hematopoietic stem and progenitor cells.
Blood. December 19, 2013 vol. 122 no. 26 4259-4263

Takahashi Y, Muramatsu H, Sakata N, Hyakuna N, Hamamoto K, Kobayashi R, Ito E, Yagasaki H, Ohara A, Kikuchi A, Morimoto A, Yabe H, Kudo K, Watanabe K, Ohga S, *Kojima S.
Rabbit antithymocyte globulin and cyclosporine as first-line therapy for children with acquired aplastic anemia.
Blood. 121: 862-3. 2012.

Wang CQ, Motoda L, Satake M, Ito Y, Taniuchi I, Tergaonkar V, *Osato M.
Runx3 deficiency results in myeloproliferative disorder in aged mice. 
Blood. 122:562-6. 2013.

Toki T, Kanezaki R, Kobayashi E, Kaneko H, Suzuki M, Wang R, Terui K, Kanegane H, Maeda M, Endo M, Mizuochi T, Adachi S, Hayashi Y, Yamamoto M, Shimizu R, *Ito E.
Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis
in Down syndrome.
Blood. 121: 3181-3184. 2013.

Saida S, Watanabe K, Sato-Otsubo A, Terui K, Yoshida K, Okuno Y, Toki T, Wang R, Shiraishi Y, Miyano S,
Kato I, Morishima T, Fujino H, Umeda K, Hiramatsu H, Adachi S, Ito E, Ogawa S, Ito M, Nakahata T,
*Heike T.
Clonal selection in xenografted TAM recapitulates the evolutionary process of myeloid leukemia in Down syndrome.
Blood. 121: 4377-4387. 2013.

Okochi N, Yoshimi A, Sato T, Ikeda T, Kumamo K, Taoka K, Sato Y, Shinohara A, Tsuruta T, Masuda A,Yokota H, Yatomi Y, Takahashi K, Kitaura J, Kitamura T, *Kurokawa M.
The shortest isoform of C/EBPβ, Liver inhibitory protein (LIP), collaborates with Evi1 to induce AML in a mouse BMT model.
Blood. 121: 4142-4155, 2013.

Takai J, Moriguchi T, Suzuki M, Yu L, Ohneda K, *Yamamoto M.
The Gata1 5' region harbors distinct cis-regulatory modules that direct gene activation in erythroid
cells and gene inactivation in HSCs.
Blood. 122:3450-3460. 2013.

Harada Y, Inoue D, Ding Y, Imagawa J, Doki N, Matsui H, Yahata T, Matsushita H, Ando K, Shashida G, Iwama A, Kitamura T, *Harada H.
Runx1/AML1 mutant collaborates with Bmi1 overexpression in the development of human and mouse myelodysplastic syndromes.
Blood. 13: 3434-3446, 2013.

Ono R, Masuya M, Nakajima H, Enomoto Y, Miyata E, Nakamura A, Ishii S, Suzuki K, Shibata-Minoshima F,Katayama N, Kitamura T, *Nosaka T.
Plzf drives MLL-fusion-mediated leukemogenesis specifically in long-term hematopoietic stem cells.
Blood. 122: 1271-1283, 2013.

Toki T, Kanezaki R, Kobayashi E, Kaneko H, Suzuki M, Wang R, Terui K, Kanegane H, Maeda M, Endo M, Mizuochi T, Adachi S, Hayashi Y, *Yamamoto M, Shimizu R, *Ito E.
Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis
in Down syndrome.
Blood. 121: 3181-3184. 2013.

Shibata K, Yamada H, Sato T, Dejima T, Nakamura M, Ikawa T, Hara H, Yamasaki S, Kageyama R, I Iwakura Y, Kawamoto H, Toh H, *Yoshikai Y.
Notch-Hes1 pathway is required for the development of IL-17-producing γδ T cells.
Blood. 118: 586-593, 2011.

*Kudo T, Sato T, Hagiwara K, Kozuma Y, Yamagami T, Ikehara Y, Hamada M, Matsumoto K, Ema M, Murata S, Ohkohchi N, Narimatsu H, *Takahashi S.
C1galt1-deficient mice exhibit thrombocytopenia due to abnormal terminal differentiation of megakaryocytes.
Blood. 122: 1649-1657, 2013.

Tanaka H, Naito T, Muroi S, Seo W, Chihara R, Miyamoto C, Kominami R and *Taniuchi I.
Epigenetic Thpok silencing limits the time window to choose CD4+ helper-lineage fate in the thymus.
EMBO J. 32:1183-94. 2013.

Okuyama K, Ikawa T, Gentner B, Hozumi K, Harnprasopwat R, Lu J, Yamashita R, Ha D, Toyoshima T, Chanda B, Kawamata T, Yokoyama K, Wang S, Ando K, Lodish HF, Tojo A, Kawamoto H,*Kotani A.
MicroRNA-126-mediated control of cell fate in B-cell myeloid progenitors as a potential alternative to transcriptional factors.
Proc. Natl. Acad. Sci. USA. 110: 13410-13415. 2013.

Wada R, Muraok N, Inagawa K, Yamakawa H, Miyamoto K, Sadahiro T, Umei T, Kaneda R, Suzuki T, Kamiya K, Tohyama S, Yuasa S, Kokaji K, Aeba R, Yozu R, Yamagishi H, Kitamura T, Fukuda K, *Ieda M.
Induction of human cardiomyocyte-like cells from fibroblasts by defined factors.
Proc. Natl. Acad. Sci. USA. 110: 12667-12672, 2013.

Okuyama K, Ikawa T, Gentner B, Hozumi K, Harnprasopwat R, Lu J, Yamashita R, Ha D, Toyoshima T, Chanda B, Kawamata T, Yokoyama K, Wang S, Ando K, Lodish H, Tojo A, *Kawamoto H, and Kotani A, MicroRNA-126-mediated control of cell fate in B-cell myeloid progenitors as a potential alternative to transcriptional factors.
Proc. Natl. Acad. Sci. USA. 110: 13410-13415. 2013.

Nakamura K, Nakayama M, Kawano M, Amagai R, Ishii T, Harigae H, *Ogasawara K.
Fratricide of NK cells dressed with tumor-derived NKG2D ligand.
Proc. Natl. Acad. Sci. USA. 110: 9421-9426, 2013.

*Pajtler KW, Weingarten C, Thor T, Kuenkele A, Heukamp LC, Büttner R, Suzuki T, Miyata N, Grotzer M, Rieb A, Sprüssel A, Eggert A, Schramm A, Schulte JH.
Lysin-specific histone demethylase 1 (LSD1/KDM1A) qualifies as promising new epigenetic therapy target in medulloblastoma.
Acta Neuropathologica Communications. 1: 19. 2013.

Kihara M, Ito K, Nakata J, Otani M, Morito M, Takahashi S, Wada Y, *Izui S.
O-linked glycosylation determines the nephritogenic potential of IgA rheumatoid factor.
J Am Soc Nephrol. 25(6):1282-90. 2014

*Okuda H, *Kawaguchi M, *Kanai A, *Matsui H, Kawamura T, Inaba T, Kitabayashi I, Yokoyama A.
MLL fusion proteins link transcriptional coactivators to previously active CpG-rich promoters.
Nucleic Acid Research. Vol. 42, No. 7 4241–4256. 2014  *co-first author.

Yoon JH, Jung SM, Park SH, Kato M, Yamashita T, Lee IK, Sudo K, Nakae S, Han JS, Kim OH, Oh BC, Sumida T, Kuroda M, Ju JH, Jung KC, Park SH, Kim DK, *Mamura M.
Activin receptor-like kinase 5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes.
EMBO Mol Med, 5(11):1720-39. 2013

Katagiri T, Kawamoto H, Nakakuki T, Ishiyama K, , Okada-Hatakeyama Ohtake S, Seiki S, Hosokawa K
and *Nakao S.
Individual hematopoietic stem cells in human bone marrow of patients with aplastic anemia or
myelodysplastic syndrome stably give rise to limited cell lineages.
Stem Cells. 31: 536-546. 2013.

Nagamatsu G, Kosaka T, Saito S, Honda H, Takubo K, Kinoshita T, Akiyama H, Sudo T, Horimoto K, Oya M, *Suda T.
Induction of pluripotent stem cells from primordial germ cells by single reprogramming factors.
Stem Cells. 31: 479-487. 2013.

Chevillard-Briet M, Quaranta M, Grézy A, Mattera L, Courilleau C, Philippe M, Mercier P, Corpet D, Lough J, Ueda T, Fukunaga R, Trouche D, *Escaffit F
Interplay between chromatin-modifying enzymes controls colon cancer progression through Wnt signaling. Hum. Mol. Genet. 15;23(8):2120-31. 2014  (doi: 10.1093/hmg/ddt604)

Saito Y, Kagami SI, Sanayama Y, Ikeda K, Suto A, Kashiwakuma D, Furuta S, Iwamoto I, Nonaka K, Ohara O, *Nakajima H.
AT-rich interactive domain-containing protein 5a functions as a negative regulator of RORyt-induced
Th17 cell differentiation.
Arthritis Rheum. doi: 10.1002/art.38324. 2013.

Kuroda I, *Inukai T, Zhang X, Kikuchi J, Furukawa Y,Nemoto A, Akahane K, Hirose K, Honna-Ooshiro H, Goi K, Kagami K, Yagita H, Tauchi T, Maeda Y, Sugita K.
BCR-ABL regulates death receptor expression for TNF-related apoptosis-inducing ligand (TRAIL) in Philadelphia chromosome-positive leukemia.
Oncogene. 32:1670-81.2013.

Koyama-Nasu R, Nasu-Nishimura Y, Todo T, Ino Y, Saito N, Aburatani H, Funato K, Echizen K, Sugano H, Haruta R, Matsui M, Takahashi R, Manabe E, Oda T, *Akiyama T.
The critical role of cyclin D2 in cell cycle progression and tumorigenicity of glioblastoma stem cells.
Oncogene. 32:3840-5.2013.

Shi Y, Frost P, Hoang B, Yang Y, Fukunaga R,Gera J, *Lichtenstein A.
MNK kinases facilitate c-myc IRES activity in rapamycin-treated multiple myeloma cells.
Oncogene. 32:190-7.2013.

Shi Y, Frost P, Hoang B, Yang Y, Fukunaga R, Gera J, *Lichtenstein A
MNK kinases facilitate c-myc IRES activity in rapamycin-treated multiple myeloma cells.
Oncogene. 32: 190-197. 2013.

Kuroda I, *Inukai T, Zhang X, Kikuchi J, Furukawa Y, Nemoto A, Akahane K, Hirose K, Honna-Ooshiro H, Goi K, Kagami K, Yagita H, Tauchi T, Maeda Y, Sugita K.
BCR-ABL regulates death receptor expression for TNF-related apoptosis-inducing ligand (TRAIL) in Philadelphia chromosome-positive leukemia.
Oncogene. 32: 1670-1681, 2013.

*Tago K, Funakoshi-Tago M, Itoh H, Furukawa Y, Kikuchi J, Kato T, Suzuki K, Yanagisawa K.
Arf tumor suppressor disrupts the oncogenic positive feedback loop including c-Myc and DDX5.
Oncogene. doi: 10.1038/onc.2013.561.

Calero-Nieto FJ, Joshi A, Bonadies N, Kinson S, Chan WI, Gudgin E, Pridans C, Landry JR, Kikuchi J, Huntly BJ, *Gottgens B.
Hox-mediated LMO2 expression in embryonic mesoderm is recapitulated in acute leukaemias.
Oncogene. 32: 5471-5480, 2013.

Suzuki M, Yamazaki H, Mukai HY, Motohashi H, Shi L, Tanabe O, Engel JD, *Yamamoto M.
Disruption of the hbs1l-myb locus causes hereditary persistence of fetal hemoglobin in a mouse model.
Mol Cell Biol. 33: 1687-1695. 2013.

Taguchi K, Hirano I, Itoh T, Tanaka M, Miyajima A, Suzuki A, *Motohashi H, and Yamamoto M.
Nrf2 enhances cholangiocyte expansion in Pten-deficient livers.
Mol. Cell. Biol. doi:10.1128/MCB.01384-13

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Konii H, Sato K, Kikuchi S, Okiyama H, Watanabe R, Hasegawa A, Yamamoto K, Itoh F, Hirano T & Watanabe T*.
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*Hirata O, Okada S, Tsumura M, Kagawa R, Miki M, Kawaguchi H, Nakamura K, Boisson-Dupuis S, Casanova J-L, Takihara Y, *Kobayashi M.
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*Kitamura H, kimura S, Shimamoto Y, Okabe J, Ito M, Miyamoto T, Naoe Y, Kikuguchi C, Meek B, Toda C, Okamoto S, Kanehira K, Hase K, Watarai H, Ishizuka M, El-Osta A, Ohara O, *Miyoshi I.
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*Kamijo S, Takeda H, Tokura T, Suzuki M, Inui K, Hara M, Matsuda H, Matsuda A, Oboki K, Ohno T, Saito H, Nakae S, Sudo K, Suto H, Ichikawa S, Ogawa H, Okumura K, *Takai T.
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*Ano S, * Morishima Y, Ishii Y, Yoh K, Yageta Y, Ohtsuka S, Matsuyama M, Kawaguchi M, Takahashi S, Hizawa N.
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*Matsuyama M, *Ishii Y, Yageta Y, Ohtsuka S, Ano S, Matsuno Y, Morishima Y, Yoh K, Takahashi S,
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*Ohishi H, Tsubaki T, Ono M, *Nose M, *Takahashi S.
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*Minagawa K, Wakahashi K, Kawano H, Nishikawa S, Fukui C, Kawano Y, Asada N, Sato M, Sada A, Katayama Y, *Matsui T.
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*Yeung M, McGrath M, Nakayama M, Shimizu T, Boenisch O, Magee C, Abdoli R, Akiba H, Ueno, T, Turka L, *Najafian N.
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*Gorentla BK, Krishna S, Shin J, Inoue M, Shinohara ML, Grayson JM, Fukunaga R, *Zhong XP
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*Nishikawa Y, Nishijima H, Matsumoto M, Morimoto J, Hirota F, Takahashi S, Luche H, Fehling HJ, Mouri Y, *Matsumoto M.
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*Takata K, Sato Y, Nakamura N, Tokunaka M, Miki Y, Yukie Kikuti Y, Igarashi K, Ito E, Harigae H, Kato S, Hayashi E, Oka T, Hoshii Y, Tari A, Okada H, Mohamad AA, Maeda Y, Tanimoto M, Kinoshita T, *Yoshino T.
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*Takeuchi M, Hirasawa A, Hara T, Kimura I, Hirano T, Suzuki T, Miyata N, Awaji T, Ishiguro M, *Tsujimoto G.
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*Miyagi S, Koide S, Wendt GR, Oshima M, Konuma T, Yamazaki S, Mochizuki-Kashio M, Chiba T, Saraya A, Kitabayashi I, Nakauchi H, *Iwama A.
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* Shiba N, Ohki K, Park MJ, Sotomatsu M, Kudo K, Ito E, Sako M, Arakawa H, *Hayashi Y.
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*Kobayashi Y, Matsui H, Kanai A, Tsumura M, Okada S, Miki M, Nakamura K, Kunishima S, Inaba T,*Kobayashi M.
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*Muramatsu D, Singh PB, Kimura H, Tachibana M, *Shinkai Y.
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*Kikuchi J, Yamada S, Koyama D, Wada T, Nobuyoshi M, Izumi T, Akutsu M, Kano Y, *Furukawa Y.
The novel orally active proteasome inhibitor K-7174 exerts anti-myeloma activity in vitro and in vivo by down-regulating the expression of class I histone deacetylases.
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*Mizoguchi Y, Tsumura M, Okada S, Hirata O, Minegishi S, Imai K, Hyakuna N, Muramatsu H, Kojima S, Sasunaga S, Takihara Y, Bryant V, Kong X-F, Cypowyj, S, Boisson-Dupuis S, Puel A, Casanova J-L, Morio T, *Kobayashi M.
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*Takagi M, Sato M, Piao J, Miyamoto S, Isoda T, Kitagawa M, Honda H, *Mizutani S.
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Akimoto T, Okuhira K, Aizawa K, Wada S, Honda H, Fukubayashi T, *Uchida T.
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Naono-Nakayama R, Ikeda T, Matsushima O, Sameshima H, Takamiya K, Funahashi H, *Nishimori T.
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Tsutajima J, Kunitake T, Wakazono Y, *Takamiya K.
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Saito T, *Chiba T, Yuki K, Zen Y, Oshima M, Koide S, Motoyama T, Ogasawara S, Suzuki E, Ooka Y, Tawada A, Tada M, Kanai F, Takiguchi Y, Iwama A, Yokosuka O.
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Nagamachi　A, Nakata Y, Ueda T, Yamasaki N, Ebihara Y, Tsuji K, Honda Zi, Takubo K, Suda T, Oda H, Inaba T, *Honda H.
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Sunami Y, Araki M, Hironaka Y, Morishita S, Kobayashi M, Liew EL, Edahiro Y, Tsutsui M, Ohsaka A,*Komatsu N.
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Terasaki M, Nagashima M, Nohtomi K, Kohashi K, Tomoyasu M, Sinmura K, Nogi Y, Katayama Y, Sato K, Itoh F, Watanabe T* & Hirano T.
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Hamajima N, Johmura Y, Suzuki S, Nakanishi M, *Saitoh S.
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Kikuchi J, Shibayama N, Yamada S, Wada T, Nobuyoshi M, Izumi T, Akutsu M, Kano Y, Sugiyama K, Ohki M, Park S-Y, *Furukawa Y.
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Katsumata T, Oishi H, Sekiguchi Y, Nagasaki H, Daassi D, Ema M, Kudo T, *Takahashi S.
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Ohno Y, Yasunaga S, Janmohamed S, Ohtubo M, Mihara K, Iscove N, *Takihara Y.
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Tomura M, Sakaue-Sawano A, Mori Y, Takase-Utsugi M, Hata A, Ohtawa K, *Kanagawa O, *Miyawaki A.
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Nishimura K, Oki T, Kitaura J, Kuninaka S, Saya H, Sakaue-Sawano A, Miyawaki A, *Kitamura T.
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Nishimoto M, Katano M, Yamagishi T, Hishida T, Kamon M, Nabeshima Y, Nabeshima Y-i, Katsura Y, Satta Y, Deakin JE, Graves JA, Kuroki Y, Ono R, Ishino F, Ema M, Takahashi S, Kato H, *Okuda A.
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Nojima A, Yamashita M, Yoshida Y, Shimizu I, Ichimiya H, Kamimura M, Kobayashi Y, Ohta S, Ishii N and *Minamino T.
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Shizuki J, Kuwahara M, Tofukuji S, Imamura M, Kato F, Nakayama T, Ohara O and *Yamashita M.
A novel small compound SH-2251 suppresses Th2 cell-dependent airway inflammation through selective modulation of chromatin status at the Il5 gene locus.
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Kubota T, *Shimojyo N, Yamashita M, Ohara O, Igoshi Y, Ozawa N, Nakano T, Morita Y, Inoue Y, Arima T, Nakamura Y, Ikegami S, Masuda K, Suzuki S and Kohno Y.
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Takase M, Iida R, Maruya M, Sakaue-Sawano A, Miyawaki A, Wakayama T, Nishigami S, Fagarasan S, *Kanagawa O.
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Sato Y, Mukai M, Ueda J, Muraki M, Timothy J. Stasevich, Horikoshi N, Kujirai T, Kita H, Kimura T, Hira S, Okada Y, Hayashi-Takanaka Y, Obuse C, Kurumizaka H, Kawahara A, Yamagata K, Nozaki N, *Kimura H.
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Nozaki Y, Mitsumori T, Yamamoto T, Kawashima I, Shobu Y, Hamanaka S, Nakajima K, Komatsu N, *Kirito K.
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Nemoto A, Inukai T, Uno K, Kiyokawa N, Miyagawa Y, Takahashi K, Sato H, Akahane K, Hirose K, Honna-Oshiro H, Goi K, Kagami K, Nakazawa S, Fujimoto J, Inaba T, *Sugita K.
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Sakane A, Alamir Mahomoud Abdallah A, Nakano K, Honda K, Kitamura T, Imoto I, Matsushita N, *Sasaki T. Junctional Rab13-binding protein (JRAB) requires cell spreading via filamins.
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Suzuki M, Kobayashi-Osaki M, Tsutsumi S, Pan X, Ohmori S, Takai J, Moriguchi T, Ohneda O, Ohneda K, Shimizu R, Kanki Y, Kodama T, Aburatani H, *Yamamoto M.
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Mukai HY, Suzuki M, Nagano M, Ohmori S, Otsuki A, Tsuchida K, Moriguchi T, Ohneda K, Shimizu R, Ohneda O, *Yamamoto M.
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Suzuki M, Kobayashi-Osaki M, Tsutsumi S, Pan X, Ohmori S, Takai J, Moriguchi T, Ohneda O, Ohneda K, Shimizu R, Kanki Y, Kodama T, Aburatani H, *Yamamoto M.
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Mukai HY, Suzuki M, Nagano M, Ohmori S, Otsuki A, Tsuchida K, Moriguchi T, Ohneda K, Shimizu R,
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Fujii Y, Kishi Y, *Gotoh Y.
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Nishigaki M, Kawada Y, Misaki T, Murata K, Goshima T, Hirokawa T, Yamada C, Shimada M, *Nakanishi M.
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Arima N, Uchida Y, Yu R, Nakayama K, *Nishina H.
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Wada T, Sakakibara Y, Nishimura R, Toma T, Ueno Y, Horita S, Tanaka T, Nishi M, Kato K, Yasumi T, Ohara O, *Yachie A.
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Osada Y, Yamada S, Nabeshima A, Yamagishi Y, Ishiwata K, Nakae S, Sudo K, *Kanazawa T.
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Arai S, Maehara N, Iwamura Y, Honda S, Nakashima K, Kai T, Ogishi M, Morita K, Kurokawa J, Mori M, Motoi Y, Miyake K, Matsuhashi N, Yamamura K, Ohara O, Shibuya A, Wakeland EK, Li QZ, *Miyazaki T.
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Imagawa J, Harada Y, Shimomura T, Tanaka H, Okikawa Y, *Harada H:
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Mori T, Okamoto K, Tanaka Y, Teye K, Umata T, Ohneda K, Tokuyama K, Okabe M, *Tsuneoka M.
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Okamura M, Yoh K, Ojima M, Morito N, *Takahashi S.
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Hasegawa Y, Daitoku Y, Sekiguchi K, Tanimoto Y, Iijima S, Mizuno S, Kajiwara N, Ema M, Miwa Y, Mekada K, Yoshiki A, Takahashi S, *Sugiyama F, Yagami K-i.
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Ikebe E, Kawaguchi A, Tezuka K, Taguchi S, Hirose S, Matsumoto T, Mitsui T, Senba K, Nishizono A, Hori M, Hasegawa H, Yamada Y, Ueno T, Tanaka Y, Sawa H, Hall W, Minami Y, Jeang KT, Ogata M, Morishita K, Hasegawa H, Fujisawa J, *Iha H.
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Hiraoka N, Kikuchi J, Koyama D, Wada T, Mori S, Nakamura Y, *Furukawa Y.
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Sripayap P, *Nagai T, Hatano K, Kikuchi J, Furukawa Y, Ozawa K.
Romidepsin overcomes cell adhesion-mediated drug resistance in multiple myeloma cells.
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Inagaki F., Tanaka M., Inagaki N., Yagai T., Sato Y., Sekiguchi K., Oyaizu N., Kokudo N., and *Miyajima A.
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*Yoshida Y, Katsurada T, Oguma S, Nakabo Y, Yoshinaga N, Kawahara M, Kawabata H.
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