2011年度 - 原著論文

* correspondence

Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, Yamamoto R, Sato Y, Sato-Otsubo A, Kon A, Nagasaki M, Chalkidis G, Suzuki Y, Shiosaka M, Kawahata R, Yamaguchi T, Otsu M, Obara N, Sakata-Yanagimoto M, Ishiyama K, Mori H, Nolte F, Hofmann WK, Miyawaki S, Sugano S, Haferlach C, Koeffler HP, Shih LY, Haferlach T, Chiba S, Nakauchi H, Miyano S, and *Ogawa S.
Frequent pathway mutations of splicing machinery in myelodysplasia.
Nature. 478: 64-69, 2011.

Totoki Y, Tatsuno K, Yamamoto S, Arai Y,, Totsuka H, Shirakihara T, Sakamoto H, Wang L, Ojima H, Shimada K, Kosuge T, Okusaka T, Kato K, Kus Hosoda F, Ishikawa S, Tsutsumi S, Sonoda Kuda J, Yoshida T, Aburatani H, Shibata T.
High-resolution characterization of a hepatocellular carcinoma genome.
Nat Genet. 43(5):464-9. 2011

Yamazaki S, Ema H, Karlsson G, Yamaguchi T, Miyoshi H, Shioda S, Taketo MM, Karlsson S, Iwama A, and *Nakauchi H.
Non-myelinating Schwann cells in the mouse bone marrow niche maintain haematopoietic stem cell hibernation through TGF-β signaling.
Cell 147:1146-1158, 2011.

Miyazaki M, Rivera RR, Miyazaki K, Lin YC, Agata Y, *Murre C.
The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells.
Nat Immunol.12: 992-1001, 2011.

Nozaki M, Wakae K, Tamaki N, Sakamoto S, Ohnishi K, Uejima T, Minato N, Yanagihara I, *Agata Y.
Regulation of TCR Vγ2 gene rearrangement by the helix-loop-helix protein, E2A.
Int Immunol. 23: 297-305, 2011.

Hishida T, Nozaki Y, Nakachi Y, Mizuno Y, Okazaki Y, Ema M, Takahashi S, Nishimoto M, *Okuda A.

Indefinite self-renewal of ES cells through Myc/Max transcriptional complexes-independent mechanisms.
Cell Stem Cell. 9: 37-49, 2011.

Tatsumi K, Yamamoto-Mukai H, Shimizu R, Waguri S, Sou Y-S, Sakamoto A, Taya C, Shitara H, Hara T, Chung CH, Tanaka K, Yamamoto M, and *Komatsu M.
The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice.
Nature Commun, 8;2:181. 2011.

Fukui R, Saitoh S-I, Kanno A, Onji M, Shibata T, Ito A, Onji M, Matsumoto M, Akira S, Yoshida N, *Miyake K.
Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking.
Immunity 35: 69-81, 2011.

*Kubota Y, Takubo K, Hirashima M, Nagoshi N, Kishi K, Sano K, Murakami M, Ema M, Omatsu Y, Takahashi S, Nagasawa T, Shibuya M, Okano H, and *Suda T. Recruitment of vascular precursors marked by myelin protein zero in postnatal vasculogenesis. J Exp Med
J Exp Med. 208(5):949-60, 2011.

Asada N, Takase M, Nakamura J, Oguchi A, Asada M, Suzuki N, Yamamura K, Nagoshi N, Shibata S, Rao TN, Fehling HJ, Fukatsu A, Minegishi N, Kita T, Kimura T, Okano H, Yamamoto M, *Yanagita M.
Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice.
J Clin Invest. 121: 3981-3990, 2011

Kitamura A, Maekawa Y, Uehara H, Izumi K, Kawachi I, Nishizawa M, Toyoshima Y, Takahashi H, Standley DM, Tanaka K, Hamazaki J, Murata S, Obara K, Toyoshima I, *Yasutomo K.
A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans.
J Clin Invest. 121: 4150-4160, 2011

Niwa Y, Shimojo H, Isomura A, Gonzalez A, Miyachi H, and *Kageyama R. Different types of oscillations in Notch and Fgf signaling regulate the spatiotemporal periodicity of somitogenesis.
Genes Dev. 25(11):1115-20. doi: 10.1101/gad.2035311, 2011.

Schonewille M, Gao Z, Boele HJ, Vinueza Veloz, MF, Amerika WE, Simek AA, De Jeu MT, Steinberg JP, Takamiya K, Hoebeek FE, et al.
Reevaluating the Role of LTD in Cerebellar Motor Learning.
Neuron. 70:43-50 2011

Makuch L, Volk L, Anggono V, Johnson RC, Yu Y, Duning K, Kremerskothen J, Xia J, Takamiya K, and *Huganir RL.
Regulation of AMPA receptor function by the human memory-associated gene KIBRA.
Neuron. 71:1022-1029 2011

Yu M, Mazor T, Huang H, Huang H.T, Kathrein K.L, Woo A.J, Chouinard C.R, Labadorf A, Akie TE, Moran T.B, Xie H, Zacharek S, Taniuchi I , Roeder R.G, Kim C.F, Zon L.I, Fraenkel E, *Cantor A.B.
Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors.
Mol Cell. 45:330-43 2012.

Hama H, Kurokawa H, Kawano H, Ando R, Shimogori T, Noda H, Fukami K, Sakaue-Sawano A, *Miyawaki A.
Scale: a chemical approach for fluorescence imaging and reconstruction of transparent mouse brain.
Nat Neurosci. 14(11): 1481-1488, 2011.

Kubota Y, Takubo K , Hirashima M, Nagoshi N, Kishi K, Okuno Y, Nakamura-Ishizu A, Sano K, Murakami M, Ema M, Omatsu Y, Takahashi S, Nagasawa T, Shibuya M, Okano H, *Suda T.
Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero.
J Exp Med. 208:949-60, 2011.

Kawatani Y, Suzuki T, Shimizu R, Kelly VP, and *Yamamoto M.
Nrf2 and selenoproteins are essential for maintaining oxidative homeostasis in erythrocytes and protecting against hemolytic anemia.
Blood. 117(3):986-96.2011

Kusakabe M, Hasegawa K, Hamada M, Nakamura M, Ohsumi T, Suzuki H, Mai TT, Kudo T, Uchida K, Ninomiya H, Chiba S, and *Takahashi S.
c-Maf plays a crucial role for the definitive erythropoiesis that accompanies erythroblastic island formation in the fetal liver.
Blood. 118: 1374-1385, 2011.

Shibata K, Yamada H, Sato T, Dejima T, Nakamura M, Ikawa T, Hara H, Yamasaki S, Kageyama R, I Iwakura Y, Kawamoto H, Toh H, *Yoshikai Y.
Notch-Hes1 pathway is required for the development of IL-17-producing γδ T cells.
Blood. 118: 586-593, 2011.

Mishima Y, Miyagi S, Saraya A, Negishi M, Endoh M, Endo TA, Toyoda T, Shinga J, Katsumoto T, Chiba T, Yamaguchi N, Kitabayashi I, Koseki H, and *Iwama A.
The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis.
Blood. 118:2443-2453, 2011.

Watanabe-Matsui M, Muto A, Matsui T, Itoh-Nakadai A, Nakajima O, Murayama K, Yamamoto M, Ikeda-Saito M, *Igarashi K.
Heme regulates B-cell differentiation, antibody class switch, and heme oxygenase-1 expression in B cells as a ligand of Bach2.
Blood. 117: 5438-5448, 2011

Mochizuki-Kashio M, Mishima Y, Miyagi S, Negishi M, Saraya A, Konuma T, Shinga J, Koseki H, and *Iwama A.
Dependency on the polycomb protein Ezh2 distinguishes fetal from adult hematopoietic stem cells.
Blood. 118:6553-6561, 2011.

Kato N, Kitaura J, Doki N, Komeno Y, Watanabe-Okochi N, Togami K, Nakahara F, Oki T, Enomoto Y, Fukuchi Y, Nakajima H, Harada Y, Harada H, and *Kitamura T.
Two types of C/EBP mutations play distinct but collaborative roles in leukemogenesis: lessons from clinical data and BMT models.
Blood. 117: 221-233, 2011.

Snow JW, Troubridge JJ, Johnson KD, Fujiwara T, Emambokus NE, Grass JA, Orkin SH, *Bresnick EH. Context-dependent function of “GATA switch” sites in vivo.
Blood. Mar 11 [Epub ahead of print]

Nitta E, Yamashita M, Hosokawa K, Xian M, Takubo K, Arai F, Nakada S, *Suda T.
Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere independent mechanism.
Blood. 2011 Feb 4. [Epub ahead of print]

Iriuchishima H, *Takubo K (These two authors contributed equally to this work), Matsuoka S, Onoyama I, Nakayama KI, Nojima Y, *Suda T.
Ex vivo maintenance of hematopoietic stem cells by quiescence induction through Fbxw7alpha overexpression.
Blood.117:2373-2377, 2011.

Sakata-Yanagimoto M, Sakai T, Miyake Y, Saito TI, Maruyama H, Morishita Y, Nakagami-Yamaguchi E, Kumano K, Yagita H, Fukayama M, Ogawa S, Kurokawa M, Yasutomo K, and *Chiba S.
Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine.
Blood. 117: 128-134, 2011.

Yoshimi Y, Goyama S, Watanabe-Okochi N, Yoshiki Y, Nannya Y, Nitta E, Arai S, Sato T, Shimabe M, Nakagawa M, Imai Y, Kitamura T, and *Kurokawa, M.
Evi1 represses PTEN expression by interacting with polycomb complexes and activates PI3K/AKT/mTOR signaling.
Blood. 117(13):3617-28, 2011.

Oshima M, Endoh M, Endo TA, Toyoda T, Nakajima-Takagi Y, Sugiyama F, Koseki H, Kyba M, *Iwama A, and *Osawa M.
Genome-wide analysis of target genes regulated by HoxB4 in hematopoietic stem and progenitor cells developing from embryonic stem cells.
Blood 117:e142-150, 2011.

Kawai Y, *Hamazaki Y, Fujita H, Fujita A, Sato T, Furuse M, Fujimoto T, Jetten AM, Agata Y, Minato N. 
Claudin-4 induction by E-protein activity in later stages of CD4/8 double-positive thymocytes to increase positive selection efficiency. 
Proc. Natl. Acad. Sci. U.S.A. 108: 4075-4080, 2011.

Makino Y, Johnson RC, Yu Y, Takamiya K, and *Huganir, RL.
Enhanced synaptic plasticity in mice with phosphomimetic mutation of the GluA1 AMPA receptor.
Proc. Natl. Acad. Sci. U.S.A. 108:8450-8455. 2011

Hassan H, Sakaguchi S, Tenno M, Kopf A, Boucheron N, Carpenter A.C, Egawa T, Taniuchi I and *Ellmeier W.
Cd8 enhancer E8I and Runx factors regulate CD8a expression in activated CD8+ T cells.
Proc. Natl. Acad. Sci. U.S.A. 108:18330-5, 2011.

Hirose Y. Saijou E. Sugano Y. Takeshita F. Nishimura S. Nonaka H. Chen Y.-R. Sekine K. Kido T. Nakamura T. Kato S. Kanke T. Nakamura K. Nagai R. Ochiya T. and *Miyajima A.
Inhibition of Stabilin-2 elevates the circulating hyaluronic acid level and prevents tumor metastasis.
Proc. Natl. Acad. Sci. U.S.A. doi:10. 1073/pnas.1117560109.

Hiratsuka S, Duda DG, Huang Y, Goel S, Sugiyama T, Nagasawa T, Fukumura D, and *Jain RK.
C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells.
Proc. Natl. Acad. Sci. U.S.A.. 108:302-307, 2011.

Sakamoto M, Imayoshi I, Ohtsuka T, Yamaguchi M, Mori K, and *Kageyama R. Continuous neurogenesis in the adult forebrain is required for innate olfactory responses.
Proc. Natl. Acad. Sci. U.S.A.. 108(20):8479-84, 2011.

*Honda H, Takubo K (These two authors contributed equally to this work), Oda H, Kosaki K, Tazaki T, Yamasaki N, Miyazaki K, Moore KA, Honda Z, Suda T, Lemischka IR.
Hemp, an mbt domain-containing protein, plays essential roles in hematopoietic stem cell function and skeletal formation.
Proc. Natl. Acad. Sci. U.S.A.. 108:2468-2473, 2011.

Okazaki IM, Okawa K, Kobayashi M, Yoshikawa K, Kawamoto S, Nagaoka H, Shinkura R, Kitawaki Y, Taniguchi H, Natsume N, Iemura SI, *Honjo T.
A histone chaperon Spt6 is required for class switch recombination but not somatic hypermutation.
Proc. Natl. Acad. Sci. U.S.A.. 108(19):7920-5, 2011.

Takashima Y, Ohtsuka T, Gonz?lez A, Miyachi H, and *Kageyama R.
Intronic delay is essential for oscillatory expression in the segmentation clock.
Proc. Natl. Acad. Sci. U.S.A.. 108: 3300-3305, 2011.

Makino Y, Johnson R, Yu Y, Takamiya K, and *Huganir R.
Enhanced synaptic plasticity in mice with phosphomimetic mutation of the GluA1 AMPA receptor.
Proc. Natl. Acad. Sci. U.S.A.. 108 (20): 8450-8455, 2011.

Kuroda T, Murayama A, Katagiri N, Ohta YM, Fujita E, Masumoto H, Ema M, Takahashi S, Kimura K, and *Yanagisawa J. RNA content in the nucleolus alters p53 acetylation via MYBBP1A.
EMBO J.. 30: 1054-1066, 2011.

Enomoto Y, Kitaura J, Hatakeyama K, Watanuki J, Akasaka T, Kato N, Shimanuki M, Nishimura K, Takahashi M, Taniwaki M, Haferlach C, Siebert S, Dyer MJS, Asou N, Nakakuma H, *Kitamura T, *Sonoki, T.
Eμ/miR-125b transgenic mice develop lethal B-cell malignancies.
Leukemia. 25:1849-1856, 2011.

*Satoh Y, Matsumura I, Tanaka H, Harada H, Harada Y, Matsui K, Shibata M, Mizuki M, Kanakura Y:
C-terminal mutation of RUNX1 attenuates the DNA-damage repair response in hematopoietic stem cells.
Leukemia. 26: 303-311, 2012.

Saito Y, Nakahata S, Yamakawa N, Kaneda K, Ichihara E, Suekane A, *Morishita K.
CD52 as a molecular target for immunotherapy to treat acute myeloid leukemia with high EVI1 expression.
Leukemia. 25:921-31 2011

Saito Y, Nakahata S, Yamakawa N, Kaneda K, Ichihara E, Suekane A, *Morishita K.
CD52 as a molecular target for immunotherapy to treat acute myeloid leukemia with high EVI1 expression.
Leukemia.. 2011 Mar 11. [Epub ahead of print]

Yuan J, Takeuchi M, Negishi M, Oguro H, Ichikawa H, and *Iwama A.
Bmi1 is essential for leukemic reprogramming of myeloid progenitor cells.
Leukemia.. 25(8):1335-43. doi: 10.1038/leu.2011.85, 2011.

Takahashi S, Ebihara A, Kajiho H, Kontani K, Nishina H, and *Katada T.
RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phospholylated-MKK7.
Cell Death Differ.. 18: 645-655, 2011.

Tsunematsu T, Kilduff TS, Boyden ES, Takahashi S, Tominaga M, *Yamanaka
A. Acute optogenetic silencing of orexin/hypocretin neurons induces slow wave sleep in mice.
J Neurosci. 31: 10529-1039, 2011.

Yamasaki T, * Kawasaki H, Arakawa S, Shimizu K, Shimizu S, Reiner O, Okano H, Nishina S, Azuma N, Penninger JM, Katada T *Nishina H .
Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex.
J. Neurosci. 31: 16872-16883, 2011.

Muraguchi T, Tanaka S, Yamada D, Tamase A, Nakada M, Nakamura H, Hoshii T, Ooshio T, Tadokoro Y, Naka K, Ino Y, Todo T, Kuratsu J, Saya H, Hamada J, *Hirao A.
NKX2.2 suppresses self-renewal of glioma-initiating cells.
Cancer Res.. 71: 1135-1145, 2011.

Morito N, Yoh K, Maeda A, Nakano T, Fujita A, Kusakabe M, Hamada M, Kudo T, Yamagata K, and *Takahashi S. A novel transgenic mouse model of the human multiple myeloma chromosomal translocation t(14;16)(q32;q23).
Cancer Res.. 71: 339-348, 2011.

Nagae G, Isagawa T, Shiraki N, Fujita T, Yamamoto S, Tsutsumi S, Nonaka A, Yoshiba S, Matsusaka K, Midorikawa Y, Ishikawa S, Soejima H, Fukayama M, Suemori H, Nakatsuji N, Kume S, *Aburatani H.
Tissue-specific demethylation in CpG-poor promoters during cellular differentiation.
Hum Mol Genet.. 2011 Apr 19. [Epub ahead of print]

Ohtsuka T, Shimojo H, Matsunaga M, Watanabe N, Kometani K, Minato N, and *Kageyama R.
Gene expression profiling of neural stem cells and identification of regulators of neural differentiation during cortical development.
Stem Cells. 29: 1817-1828, 2011.

Kurosaka H, Isu N,Kuremoto K, Hayano S, Kawanabe N, Rice D, Harada H, Ornitz D, Taniuchi I, and *Yamashiro T.
Core binding factor beta (Cbfb) function in the maintenance of stem cells and also orchestrate continuous proliferation and differentiation in developing tooth incisors.
Stem cell.s 29:1792-1803, 2011.

Ohtsuka M, Ogiwara S, Miura H, Mizutani A, Warita T, Sato M, Imai K, Hozumi K. Sato T, Tanaka M, Kimura M, Inoko H
Pronuclear injection-based mouse targeted transgenesis for reproducible and highly efficient transgene expression
Nucleic Acids Res. 32:e198, 2011

Takahashi S, Sakurai K, Ebihara A, Kajiho H, Saito K, Kontani K, Nishina H, and *Katada T.
RhoA activation participates in rearrangement of processing bodies and release of nucleated AU-rich mRNAs.
Nucleic Acids Res.. 39(8):3446-57, 2011.

Nishikata I, Nakahata S, Saito Y, Kaneda K, Ichihara E, Yamakawa N, *Morishita K.
Sumoylation of MEL1S at lysine 568 and its interaction with CtBP facilitates its repressor activity and the blockade of G-CSF-induced myeloid differentiation.
Oncogene. 30:4194-4207 2011

Ehata S, Johansson E, Katayama R, Koike S, Watanabe A, Hoshino Y, Katsuno Y, Komuro A, Koinuma D, Kano MR, Yashiro M, Hirakawa K, Aburatani H, Fujita N, Miyazono K.
Transforming growth factor-β decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells.
Oncogene.. 30(14):1693-705. 2011

Kamitani-Kawamoto A, Hamada M, Moriguchi T, Miyai M, Hitoshi S, Ikenaka K, Hosoya T, Hotta Y, Takahashi S, *Kataoka K.
MafB interacts with Gcm2 and regulates parathyroid hormone expression and parathyroid development.
J Bone Mineral Res. 26: 2463-2472, 2011.

Ishitobi H, Wakamatsu A, Lui F, Azami T, Hamada M, Matsumoto K, Kataoka H, kobayashi M, Choi K, Nishikawa S-I, Takahashi S, *Ema M,
Molecular basis for Flk1 expression in hemato-cardiovascular progenitors in the mouse.
Development. 138: 5357-5368, 2011.

Kamio T, Ito E, Ohara A, Kosaka Y, Tsuchida M, Yagasaki H, Mugishima H, Yabe H, Morimoto A, Ohga S, Muramatsu H, Hama A, Kaneko T, Nagasawa M, Kikuta A, Osugi Y, Bessho F, Nakahata T, Tsukimoto I, * Kojima S.
Relapse of aplastic anemia in children after immunosuppressive therapy: a report from the Japan Childhood Aplastic Anemia Study Group.
Haematologica.. [Epub ahead of print]

Matsuyama M, Goto H, Kasahara K, Kawakami Y, Nakanishi M , Kiyono T, Goshima N, Inagaki M.
Nuclear Chk1 prevents premature mitotic entry.
J Cell Sci. 124 2113-9, 2011.

Wada N, Nishifuji K, Yamada T, Kudoh J, Shimizu N, Matsumoto M, Peltonen L, Nagafuchi S, *Amagai M.
Aire-dependent thymic expression of desmoglein 3, the autoantigen in pemphigus vulgaris, and its role in T cell tolerance.
J Invest Dermatol. 131: 410-417, 2011.

Suzuki N, Obara N, Pan X, Watanabe M, Jishage K, Minegishi N, *Yamamoto M.
Specific contribution of the erythropoietin gene 3' enhancer to hepatic erythropoiesis after late embryonic stages.
Mol Cell Biol. 31: 3896-3905, 2011.

Tozawa H, Kanki Y, Suehiro JI, Tsutsumi S, Kohro T, Wada Y, Aburatani H, Aird WC, Kodama T, Minami T.
Genome-wide approaches reveal functional IL-4 inducible STAT6 binding to the vascular cell adhesion molecule-1 promoter.
Mol Cell Biol. 2011 Apr 4. [Epub ahead of print]

Suzuki N, Obara N, Pan X, Watanabe M, Jishage K, Minegishi N, *Yamamoto M.
Specific contribution of the erythropoietin gene 3' enhancer to hepatic erythropoiesis after late embryonic stages.
Mol Cell Biol. 31: 3896-3905, 2011.

Bae YH, Park HJ, Kim SR, Kim JY, Kang Y, Kim JA, Wee HJ, Kageyama R, Jung JS, Bae MK, *Bae SK.
Notch1 mediates visfatin-induced FGF-2 up-regulation and endothelial angiogenesis.
Cardiovasc Res. 89: 436-445, 2011.

Tachibana M, Tezuka C, Tenno M, Sugiyama M, Yoshida H and Taniuchi I.
Runx1/Cbfb2 complexes are required for lymphoid tissue inducer cell differentiation at two developmental stages.
J. Immunol. 1;186(3):1450-7. 2011.

Magari M, Nishikawa Y, Fujii Y, Nishio Y, Watanabe K, Fujiwara M, Kanayama N, *Ohmori H.
IL-21-dependent B cell death driven by prostaglandin E2, a product secreted from follicular dendritic cells.
J Immunol. 187: 4210-4218, 2011.

Mouri Y, Yano M, Shinzawa M, Shimo Y, Hirota F, Nishikawa Y, Nii T, Kiyonari H, Abe T, Uehara H, Izumi K, Tamada K, Chen L, Penninger JM, Inoue J, *Akiyama T, and *Matsumoto M.
Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma.
J Immunol. 186: 5047-5057, 2011.

Tachibana M, Tenno M, Tezuka C, Sugiyama M, Yoshida H and *Taniuchi I. Runx1/Cbfb2 complexes are required for lymphoid tissue inducer cell differentiation at two developmental stages.
J. Immunol. 186:1450-57, 2011.

Kumadaki S, Karasawa T, Matsuzaka T, Ema M, Nakagawa Y, Nakakuki M, Saito R, Yahagi N, Iwasaki H, Sone H, Takekoshi K, Yatoh S, Kobayashi K, Takahashi A, Suzuki H, Takahashi S, Yamada N, *Shimano H.
Inhibition of Ubiquitin ligase F-box and WD repeat domain-containing 7α (Fbw7α) causes hepatosteatosis through the Kruppel-like factor 5 (KLF5)/PPAR γ 2 pathway, but not SREBP-1c in mice.
J Biol Chem. 286: 40835-40846, 2011.

Ozaki Y, Matsui H, Nagamachi A, Asou H, Aki D, *Inaba T.
The dynactin complex maintains the integrity of metaphasic centrosomes to ensure transition to anaphase.
J. Biol. Chem. 286(7):5589-98. 2011.

Yukiura H, Hama K, Nakanaga K, Tanaka M, Asaoka Y, Okudaira S, Arima N, Inoue A, Hashimoto T, Arai H, Kawahara A,Nishina H, *Aoki J.
Autotaxin regulates vascular development via multiple lysophosphatidic acid (LPA) receptors in zebrafish.
J. Biol. Chem. 286: 43972-43983, 2011.

Nagamatsu G, Kosaka T, Kawasumi M, Kinoshita T, Takubo K, Akiyama H, Sudo T, Kobayashi T, Oya M, Suda T.
A germ cell specific gene, Prmt5 works as somatic cell reprogramming.
J Biol Chem. 2011 Jan 26. [Epub ahead of print]

Joshi S, Sharma B, Kaur S, Majchrzak B, Ueda T, Fukunaga R, Verma A K, Fish E N, and *Platanias L C.
Essential role for Mnk kinases in Type II interferon (IFNγ) - signaling and its suppressive effects on normal hematopoiesis.
J Biol Chem. 286: 6017-6026, 2011.

Sato K, Miyoshi F, Yokota K, Araki Y, Asanuma Y, Akiyama Y, Yoh K, Takahashi S, Aburatani H, Mimura T.
Marked induction of c-Maf during Th17 differentiation and its implication in memory Th cell development.
J Biol Chem. 286(17):14963-71, 2011.

Daigo K, Kawamura T, Ohta Y, Ohashi R, Katayose S, Tanaka T, Aburatani H, Naito M, Kodama T, Ihara S, Hamakubo T.
Proteomic analysis of native hepatocyte nuclear factor-4{alpha} (HNF4{alpha}) isoforms, phosphorylation status, and interactive cofactors.
J Biol Chem. 286(1):674-86. 2011

*Sato K, Miyoshi F, Yokota K, Araki Y, Asanuma Y, Akiyama Y, Yoh K, Takahashi S, Aburatani H, and Mimura T. Marked induction of c-Maf during Th17 differentiation and its implication in memory Th cell development.
J Biol Chem. 286(17):14963-71.2011

Matsumoto A, Onoyama I, Sunabori T, Kageyama R, Okano H, and *Nakayama KI.
Fbxw7-dependent Degradation of Notch Is Required for Control of Stemness and Neuronal-Glial Differentiation in Neural Stem Cells.
J Biol Chem. 286: 13754-13764, 2011.

Sato T, Kudo T, Ikehara Y, Ogawa H, Hirano T, Kiyohara K, Hagiwara K, Togayachi A, Ema M, Takahashi S, Kimata K, Watanabe H, and *Narimatsu H. Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is necessary for normal endochondral ossification and aggrecan metabolism.
J Biol Chem. 286: 5803-12, 2011.

Yang YM, Aitoubah J, Lauer AM, Nuriya M, Takamiya K, Jia Z, May BJ, Huganir RL, and *Wang, LY.
GluA4 is Indispensable for Driving Fast Neurotransmission across a High-fidelity Central Synapse.
J Physiol.　589:4209-27 2011.

Miyaoka Y. Kato H. Ebato K. Saito S. Miyata N. Imamura T. and *Miyajima A.
Retention in the Golgi apparatus and expression on the cell surface of Cfr/Esl-1/Glg-1/MG-160 are regulated by two distinct mechanisms.
Biochemical Journal. 44: 33-41, 2011.

Guo Y, Miyazaki M, Itoi M, Satoh R, Iwama A, Amagai T, Kawamoto H, and *Kanno M.
Polycomb group gene Bmi1 plays a role in the growth of thymic epithelial cells.
Eur J Immunol. 41: 1098-1107, 2011.

Xu M, Morishima N, Mizoguchi I, Chiba Y, Fujita K, Kuroda M, Iwakura Y, Cua DJ, Yasutomo K, Mizuguchi J, *Yoshimoto T.
Regulation of the development of acute hepatitis by IL-23 through IL-22 and IL-17 production.
Eur J Immunol. 41: 2828-2839, 2011.

Ozaki Y, Matsui H, Nagamachi A, Asou H, Aki D, and *Inaba T.
The dynactin complex maintains the integrity of metaphasic centrosomes to ensure transition to anaphase.
J Biol Chem. 286: 5589-5598, 2011.

Ishifune C, Maekawa Y, Nishida J, Kitamura A, Tanigaki K, Yagita H, and *Yasutomo K. Notch signaling regulates the development of a novel type of Thy1-expressing dendritic cell in the thymus.
Eur J Immunol. 41(5):1309-20.2011.

Guo Y, Miyazaki M, Itoi M, Satoh R, Iwama A, Amagai T, Kawamoto H, and *Kanno M.
Polycomb group gene Bmi1 plays a role in the growth of thymic epithelial cells.
Eur J Immunol. 41: 1098-1107, 2011.

*Chiba T, Suzuki E, Negishi M, Saraya A, Miyagi S, Konuma T, Tanaka S, Tada M, Kanai F, Imazeki F, Iwama A, and *Yokosuka O.
3-deazaneplanocin is a promising therapeutic agent for the eradication of tumor-initiating hepatocellular carcinoma cells.
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Ueno S, Umeki K, Takajo I, Nagatomo Y, Kusumoto N, Umekita K, Morishita K, and *Okayama
A. Proviral loads of human T-lymphotropic virus type 1 in asymptomatic carriers with different infection routes.
Int J Cancer. 2011 Jul 21. [Epub ahead of print].

Takeda Y, Nakaseko C, Tanaka H, Takeuchi M, Yui M, Saraya A, Miyagi S, Wang C, Tanaka S, Ohwada C, Sakaida E, Yamaguchi N, Yokote K, Hennighausen L, and *Iwama A.
Direct activation of STAT5 by ETV6-Lyn fusion protein promotes induction of myeloproliferative neoplasm with myelofibrosis.
Br J Haematol. 153:589-598, 2011.

Kozuma Y, Sawahata Y, Takei Y, Chiba S, and *Ninomiya H.
Procoagulant properties of microparticles released from red blood cells in paroxysmal nocturnal haemoglobinuria.
Br J Haematol. 152: 631-639, 2011.

DeFalco T, Takahashi S, *Capel B. Two distinct origins for Leydig cell progenitors in the fetal testis.
Dev Biol. 352: 14-26, 2011.

Tateya T, Imayoshi I, Tateya I, Ito J, and *Kageyama R.
Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development.
Dev Biol.. 352: 329-340, 2011.

Qin H, Suzuki, K., Nakata M, Chikuma S, Izumi N, Thi Huong L, Maruya M, Fagarasan S, Busslinger M, Honjo T*, and Nagaoka H*.
Activation-Induced Cytidine Deaminase Expression in CD4 T Cells is Associated with a Unique IL-10-Producing Subset that Increases with Age.
PLoS One. 6, e29141, 2011.

Nishino T, Wang C, Mochizuki-Kashio, M, Osawa, M, Nakauchi, H, and *Iwama A.
Ex vivo expansion of human hematopoietic stem cells by Garcinol, a potent inhibitor of histone acetyltransferase.
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Kajiro M, Tsuchiya M, Kawabe Y, Furumai R, Iwasaki N, Hayashi Y, Katano M, Nakajima Y, Goto N, Watanabe T, Murayama A, Oishi H, Ema M, Takahashi S, Kishimoto H, *Yanagisawa J.
The e3 ubiquitin ligase activity of trip12 is essential for mouse embryogenesis.
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*Saito H. Takeuchi M. Chida K. and *Miyajima A.
Generation of glucose-responsive functional islets with a three-dimensional structure from mouse fetal pancreatic cells and iPS cells in vitro.
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Tsukahara Y. *Tanaka M. and *Miyajima A.
TROP2 expressed in the trunk of the ureteric duct regulates branching morphogenesis during kidney development.
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Pan X, Suzuki N, Hirano I, Yamazaki S, Minegishi N, *Yamamoto M.
Isolation and characterization of renal erythropoietin-producing cells from genetically produced anemia mice.
PLoS One. 6: e25839, 2011

Sugiyama M, Tanaka Y, Wakita T, Nakanishi M, Mizokami M.
Genetic variation of the IL-28B promoter affecting gene expression.
PLoS One. 6(10):e26620 2011

Goel A, Xu LW, Snyder KP, Song L, Goenaga-Vazquez Y, Megill A, Takamiya K, *Huganir RL, and Lee HK.
Phosphorylation of AMPA receptors is required for sensory deprivation-induced homeostatic synaptic plasticity.
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Fujita T, *Fujii H.
Direct identification of insulator components by insertional chromatin immunoprecipitation.
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*Mori N, Ishikawa C, Senba M, Kimura M, Okano Y.
Effects of AZD1152, a selective Aurora B kinase inhibitor, on Burkitt's and Hodgkin's lymphomas.
Biochem Pharmacol. 81: 1106-1115, 2011.

Mizutani E, Suzumori N, Ozaki Y, Oseto K, Yamada-Namikawa C, Nakanishi M , Sugiura-Ogasawara M.
SYCP3 mutation may not be associated with recurrent miscarriage caused by aneuploidy.
Hum Reprod. 26(5) :1259-66, 2011

Jin L, *Tabe Y, Kimura S, Zhou Y, Kuroda J, Asou H, Inaba T, Konopleva M, Andreeff M, and Miida T.
Antiproliferative and proapoptotic activity of GUT-70 mediated through potent inhibition of Hsp90 in mantle cell lymphoma.
Br J Cancer. 104: 91-100, 2011.

Tran TC, Kimura K, Nagano M, Yamashita T, Ohneda K, Sugimori H, Sato F, Sakakibara Y, Hamada H, Yoshikawa H, Hoang SN　and *Ohneda O.
Identification of human placenta-derived mesenchymal stem cells involved in re-endothelialization.
J Cell Physiol. 226: 224-235, 2011.

Wang W, Petralia RS, Takamiya K, Xia J, Li YQ, Huganir RL, Tao YX, and *Yaster M
Preserved acute pain and impaired neuropathic pain in mice lacking protein interacting with C Kinase 1.
Molecular pain. 7:1-11.2011

Ouchi Y, Baba Y, Koso H, Taketo MM, Iwamoto T, Aburatani H, Watanabe S.
β-Catenin signaling regulates the timing of cell differentiation in mouse retinal progenitor cells.
Mol Cell Neurosci. 2011 Feb 24. [Epub ahead of print]

Baba Y, Iida, A and *Watanabe S.
Sall3 plays essential roles in horizontal cell maturation through regulation of neurofilament expression levels.
Biochimie.46: 770-780, 2011

*Kato K, Yoshimi A, Ito E, Oki K, Hara J, Nagatoshi Y, Kikuchi A, Kobayashi R, Nagamura-Inoue T, Kai S, Azuma H, Takanashi M, Isoyama K, Kato S
Japan Cord Blood Bank Network. Cord blood transplantation from unrelated donors for children with acute lymphoblastic leukemia in Japan: the impact of methotrexate on clinical outcomes.
Biol Blood Marrow Transplant. 17:1814-21, 2011.

Iida A, Shinoe,T, Baba,Y, Mano H, and *Watanabe S.
Dicer plays essential roles for retinal development by regulation of survival and differentiation.
Invest Ophthalmol Vis Sci. 52(6):3008-17.2011.

Chiba T, Miyashita K, Sugoh T, Warita T, Inoko H, Kimura M, Sato T
IκBL, a novel member of the nuclear IκB family, inhibits inflammatory cytokine expression
FEBS Letters. 585:3577-3581, 2011

Feng L, Eisenstat DD, Chiba S, Ishizaki Y, Gan L, and *Shibasaki K.
Brn-3b inhibits generation of amacrine cells by binding to and negatively regulating DLX1/2 in developing retina.
Neuroscience. 195: 9-20, 2011.

Jin L, Tabe Y, Kimura S, Zhou Y, Kuroda J, Asou H, *Inaba T, Konopleva M, Andreeff M, Miida T*. Antiproliferative and proapoptotic activity of GUT-70 mediated through potent inhibition of Hsp90 in mantle cell lymphoma. Br. J. Cancer. 104(1):91-100. 2011.

Morita Y, Iseki A, Okamura S, Suzuki S, Nakauchi H, and *Ema H.
Functional characterization of hematopoietic stem cells in the spleen.
Exp Hematol. 39: 351-359, 2011.

Konuma T, Nakamura S, Miyagi S, Negishi M, Chiba T, Oguro H, Yuan J, Mochizuki-Kashio M, Ichikawa H, Miyoshi H, Vidal M and *Iwama A
Forced expression of the histone demethylase Fbxl10 maintains self-renewing hematopoietic stem cells.
Exp Hematol.39, 697-709, 2011.

Kudo K, *Terui K, Sasaki S, Kamio T, Sato T, Ito E.　
Voriconazole for both successful treatment of disseminated Trichosporon asahii infection and subsequent cord blood transplantation in an infant with acute myelogenous leukemia.
Bone Marrow Transplant.. 46: 310-311, 2011.

Yoshioka T, Kimura M, Saio M, Era S, and Okano Y*.
Plk1 is negatively regulated by RNF8.
Biochem Biophys Res Commun. 410, 57-61,　2011

Kobayashi Y, Yokoi T, Yokoi T, Hiraoka H, Nishina S, *Azuma N.
Fluorescein staining of the vitreous during vitrectomy for retinopathy of prematurity.
Retina. 31: 1717-1719, 2011.

Fujita T, and Fujii H.
Species-specific 5'-genomic structure and multiple transcription start sites in the chicken Pax5 gene.
Gene. 477: 24-31, 2011.

Ichihara E, Kaneda K, Saito Y, Yamakawa N, *Morishita K.
Angiopoietin1 contributes to the maintenance of cell quiescence in EVI1high leukemia cells.
Biochem Biophys Res Commun.416:239-245 2011

Miyamura N, Nakamura T, Goto-Inoue N, Zaima N, Hayasaka T, Yamasaki T, Terai S, Sakaida I, Setou M and *Nishina H.
Imaging mass spectrometry reveals characteristic changes in triglyceride and phospholipid species in regenerating mouse liver.
Biochem Biophys Res Commun.408(1):120-5, 2011.

Kinoshita T, *Nagamatsu G, Kosaka T, Takubo K, Hotta A, Ellis J, *Suda T.
Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells.
Biochem Biophys Res Commun. 2011 Mar 6. [Epub ahead of print]

Morishita S, Komatsu N, Kirito K, Koda AH, Sekiguchi Y, Tsuneda S, and *Noda N.
Alternately binding probe competitive PCR as a simple, cost-effective, and accurate quantification method for JAK2V617F allele burden in myeloproliferative neoplasms.
Leuk Res. 35(12):1632-1636, 2011.

Tauchi T, *Kizaki M, Okamoto S, Tanaka H, Tanimoto M, Inokuchi K, Murayama T, Saburi Y, Hino M, Tsudo M, Shimomura T, Isobe Y, Oshimi K, Dan K, Ohyashiki K, Ikeda Y. and the TARGET Investigators (including Furukawa Y)
Seven-year follow-up of patients receiving imatinib for the treatment of newly diagnosed chronic myelogenous leukemia by the TARGET system.
Leuk Res.35: 585-590, 2011.

Kudo K, *Terui K, Sasaki S, Kamio T, Sato T, and Ito E
CD7-positive acute myelomonocytic leukemia with trisomy 21 as a sole acquired chromosomal abnormality in two adolescents.
Leuk Res. 35(9):e167-8.2011

Suzuki S, Kim O-H, Makita Y, Saito T, Lim G-Y, Cho T-J, Al-Swaid A, Alrashees S, Sadoon E, Miyazaki O, Nishina S, Superti-Furga A, Unger S, K, Ikegawa S, *Nishimura G.
Axial Spondylometaphyseal Dysplasia: Additional Reports. Am J Med Genet A. 155A: 2521-2528, 2011.

*Hiraki Y, Nishimura A, Hayashidani M, Terada Y, Nishimura G, Okamoto N, Nishina S, Tsurusaki Y, Doi H, Saitsu H, Miyake N, Matsumoto N.
A de novo deletion of 20q11.2-q12 in a boy presenting with abnormal hands and feet, retinal dysplasia, and intractable feeding difficulty.
Am J Med Genet A. 155A: 409-414, 2011.

Harada N, Watanabe Y, Yoshimura Y, Sakumoto H, Makishima F, Tsuchiya M, Nakanishi K, Nakanishi M, Aoki Y.
Identification of a checkpoint modulator with synthetic lethality to p53 mutants.
Anticancer Drugs. 22 986-94, 2011.

Hisanaga T, *Terai S, Iwamoto T, Takami T, Yamamoto N, Murata T, Matsuyama T, Nishina H, Sakaida I.
TNFR1 mediated signaling is important to induce the improvement of liver fibrosis by bone marrow cell infusion.
Cell Tissue Res. 346: 79-88, 2011.

Kuwashiro S, Terai S, Oishi T, Koichi F, Matsumoto T, Nishina H, and Sakaida I.
Telmisartan improved nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation.
Cell Tissue Res 344: 125-134, 2011.

Sugiyama M, Tanaka Y, Nakanishi M , Mizokami M.
Novel findings for the development of drug therapy for various liver diseases: Genetic variation in IL-28B is associated with response to the therapy for chronic hepatitis C.
J Pharmacol Sci. 115(3):263-9, 2011.

Bao Y, Nakagawa K, Yang Z, Ikeda M, Withanage K, Ishigami-Yuasa M, Okuno Y, Hata S, Nishina H, *Yutaka Hata.
A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription.
J. Biochem. 150: 199-208, 2011.

Fujiwara M, Kashima TG, Kunita A, Kii I, Komura D, Grigoriadis AE, Kudo A, Aburatani H, Fukayama M.
Stable knockdown of S100A4 suppresses cell migration and metastasis of osteosarcoma.
Tumour Biol.2011 Mar 1. [Epub ahead of print]

Sugiyama M, Inui A, Shin-I T, Komatsu H, Mukaide M, Masaki N, Murata K, Ito K, Nakanishi M, Fujisawa T, Mizokami M.
Easy-to-use phylogenetic analysis system for hepatitis B virus infection.
Hepatol Res. 41(10):936-945, 2011.

Osaki T, Uchida Y, *Hirayama J, Nishina H.
Diphenyleneiodonium chloride, an inhibitor of NADPH oxidase, suppresses light-dependent induction of clock and DNA repair genes in zebrafish.
Biol. Pharm. Bull. 34: 1343-1347, 2011.

Yoshida C, Komeno T, Hori M, Kimura T, Fujii M, Okoshi Y, Suzukawa K, Chiba S, Hasegawa Y, Mukai HY, Ito T, Shimizu S, Kamoshita M, Kudo D, Shinagawa A, Chikatsu N, Monma Y, Watanabe N, and *Kojima H.
Adherence to the standard dose of imatinib, rather than dose adjustment based on its plasma concentration, is critical to achieve a deep molecular response in patients with chronic myeloid leukemia.
Int J Hematol. 93: 618-623, 2011

Wakahashi K, Yamamori M, *Minagawa K, Ishii S, Nishikawa S, Shimoyama M, Kawano H, Kawano Y, Kawamori Y, Sada A, Matsui T, and Katayama Y.
Pharmacokinetics-based optimal dose prediction of donor source-dependent response to mycophenolate mofetil in unrelated hematopoietic cell transplantation.
Int J Hematol. 94: 193-202, 2011.

Tanaka M, *Nishina S, Ogonuki S, Akaike S, Azuma N.
Nishida’s procedure combined with medial rectus recession for large-angle esotropia in Duane syndrome.
Jpn J Ophthalmol. 55: 264-267, 2011.

Nitta H, Harada Y, Okikawa Y, Fujii M, Arihiro K, Kimura A, *Harada H.
Good’s syndrome-associated pure red cell aplasia with myelodysplastic syndrome.
Intern Med. 50: 2011-2014, 2011

Yamagata K, Onizawa K, Yanagawa T, Takeuchi Y, Hasegawa Y, Chiba S, and
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Prospective study establishing a management plan for impacted third molar in patients undergoing hematopoietic stem cell transplantation.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod.. 111: 146-152, 2011.

*Kai H, Akamatsu E, Torii E, Kodama H, Yukizak Ci, Sakakibar Y, Suiko M, * Morishita K, Kataoka H, Matsuno K
Inhibition of proliferation by agricultural plant extracts in seven human adult T-cell leukaemia (ATL)-related cell lines.
J Nat Med. 65:651-655 2011.

Mitsunaga K, Kikuchi J, Wada T, and *Furukawa Y.
Latexin regulates the abundance of multiple cellular proteins in hematopoietic stem cells.
J Cell doi: 10.1002/jcp.22834, 2011.

Kurita N, Nishikii H, Nakamoto R, Nakamura N, Kondo Y, Okoshi Y, Suzukawa K, Hasegawa Y, Yokoyama Y, Noguchi M, and *Chiba S.
A highly therapy-resistant case with “B-cell lymphoma unclassifiable with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma” showing strong BCL2 staining, otherwise indistinguishable from Burkitt lymphoma.
J Clin Exp Hematopathol. 51 (1）：37-42, 2011.

Sakaue-Sawano A, * Miyawaki A.
Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progressions.
Cold Spring Harbor Laboratory Press, Imaging in Developmental Biology:A Laboratory Manual. 2011.

Yokoyama Y, Nishikii H, and *Chiba S.
Hematopoietic differentiation from embryonic stem cells.
Embryonic Stem Cells. 251-272, 2011